Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease

Bonasoni, Maria Paola; Palicelli, Andrea; Dea, Giulia Dalla; Comitini, Giuseppina; Pazzola, Giulia; Russello, Giuseppe; Bertoldi, Graziella; Bardaro, Marcellino; Zuelli, C.; Carretto, Edoardo

doi:10.3390/diagnostics11020243

Cited by 12 publications

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“…Systematic literature reviews and metanalyses (SLRs) conducted according to the PRISMA guidelines (including an evidence-based minimum set of items for reporting) ( , accessed on 8 May 2021) are increasingly important in health care, keeping medical doctors up to date, and also representing the background for developing clinical guidelines/trials, as well as the justification for financial supports of research projects. Usually conducted by multidisciplinary teams, SLRs performed according to these guidelines could be applicable in various topics/contexts, improving the research quality not only of pure meta-analyses but also of SLRs applied to case report/series [ 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , …”

Section: Discussionmentioning

confidence: 99%

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review (Part 6): Correlation of PD-L1 Expression with the Status of Mismatch Repair System, BRCA, PTEN, and Other Genes

et al. 2022

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Pembrolizumab (anti-PD-1) is allowed in selected metastatic castration-resistant prostate cancer (PC) patients showing microsatellite instability/mismatch repair system deficiency (MSI-H/dMMR). BRCA1/2 loss-of-function is linked to hereditary PCs and homologous recombination DNA-repair system deficiency: poly-ADP-ribose-polymerase inhibitors can be administered to BRCA-mutated PC patients. Recently, docetaxel-refractory metastatic castration-resistant PC patients with BRCA1/2 or ATM somatic mutations had higher response rates to pembrolizumab. PTEN regulates cell cycle/proliferation/apoptosis through pathways including the AKT/mTOR, which upregulates PD-L1 expression in PC. Our systematic literature review (PRISMA guidelines) investigated the potential correlations between PD-L1 and MMR/MSI/BRCA/PTEN statuses in PC, discussing few other relevant genes. Excluding selection biases, 74/677 (11%) PCs showed dMMR/MSI; 8/67 (12%) of dMMR/MSI cases were PD-L1+. dMMR-PCs included ductal (3%) and acinar (14%) PCs (all cases tested for MSI were acinar-PCs). In total, 15/39 (39%) PCs harbored BRCA1/2 aberrations: limited data are available for PD-L1 expression in these patients. 13/137 (10%) PTEN- PCs were PD-L1+; 10/29 (35%) PD-L1+ PCs showed PTEN negativity. SPOP mutations may increase PD-L1 levels, while the potential correlation between PD-L1 and ERG expression in PC should be clarified. Further research should verify how the efficacy of PD-1 inhibitors in metastatic castration-resistant PCs is related to dMMR/MSI, DNA-damage repair genes defects, or PD-L1 expression.

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Section: Discussionmentioning

confidence: 99%

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review (Part 6): Correlation of PD-L1 Expression with the Status of Mismatch Repair System, BRCA, PTEN, and Other Genes

et al. 2022

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“…Few cases of confirmed K. kingae meningitis are also reported in children and young adults 7. There is also a case report of chorioamnionitis and intrauterine infection leading to premature rupture of membrane and miscarriage due to K. kingae infection 8…”

Section: Discussionmentioning

confidence: 99%

Rare case of infective aortitis with aortic rupture and cardiac tamponade in a young child

2022

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Aortitis and aortic dissection are very rare in children. The clinical presentation of aortitis varies across a spectrum, ranging from incidental findings to fatal aortic dissection and rupture. A high index of suspicion is needed to establish an accurate and timely diagnosis. Here, we present an unfortunate case of fatal infective aortitis with aortic rupture and cardiac tamponade in a healthy toddler. Postmortem report implicatedKingella kingaeas the causative organism of aortic pseudoaneurysm and rupture, leading to the instantaneous death of the child.

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“…_________________________________________________________________________________________________ инфицирования нижнего полюса плодного яйца требует дальнейшего изучения. Так, M. Bonasoni et al (2021) описали клиническое наблюдение ПРПО в 22 недели с дальнейшим мертворождением, в плаценте, из ушка и носоглотки новорожденного была выделена чистая культура Kingella kingae -представителя семейства Neisseriaceae. Этот возбудитель часто обнаруживают на коже детей до 4 лет, в большинстве случаевв виде бессимптомного носительства, но иногда он становится причиной артрита, остеомиелита, эндокардита.…”

Section:  введениеunclassified

“…Этот возбудитель часто обнаруживают на коже детей до 4 лет, в большинстве случаевв виде бессимптомного носительства, но иногда он становится причиной артрита, остеомиелита, эндокардита. Авторы подчеркивают, что не описано случаев колонизации возбудителем влагалища, то есть путь инфицирования в описанном ими наблюдении может быть только гематогенным [4]. Клиническое наблюдение демонстрирует, что источник инфицирования амниона может быть совершенно неожиданным.…”

Section:  введениеunclassified

Концентрация Глюкозы В Околоплодных Водах Как Маркер Воспаления Амниотических Оболочек При Их Преждевременном Разрыве При Недоношенной И Доношенной Беременности

Белая¹,

Загородняя²,

Tsapenko³

et al. 2022

Репродуктивное Здоровье. Восточная Европа

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В статье предложены результаты исследования концентрации глюкозы в амниотической жидкости в качестве раннего маркера воспалительного процесса в оболочках. Для этого проанализировано течение беременности и родов у женщин с преждевременным разрывом плодных оболочек при доношенной и в зависимости от амниотической концентрации глюкозы. Выжидательная тактика при преждевременном разрыве амниотических мембран на сегодня доминирует в мире, при этом ведущим критерием развития хориоамнионита являются клинические признаки, а затем - лабораторные. Показано, что у женщин с амниотической концентрацией глюкозы при госпитализации менее 0,5 ммоль/л чаще фиксируют гипертермию как до начала родовой деятельности, так и в родах, а особенно чаще - гипертермию в течение первых 12 часов от момента разрыва околоплодных оболочек. Кроме того, им более характерны и другие осложнения родов - дистресс плода, слабость родовой деятельности, а также чаще возникает необходимость оперативного родоразрешения. Полученные данные дают основания предполагать индивидуальный подход к выбору тактики ведения при преждевременном разрыве оболочек. The article presents the results of studying the concentration of glucose in the amniotic fluid as an early marker of the inflammatory process in the membranes. For this we analyzed the course of the pregnancy and childbirth in women with premature rupture of membranes at full-term labor and preterm labor depending on the amniotic concentration of glucose. Nowadays, expective tactic in case of preterm membrane rupture dominates in the world. The leading criteria of the diagnosis of chorioamnionitis are based on clinical signs at first, and at the second on lab indicators. It has been shown that in women with amniotic glucose concentration less than 0.5 mmol/l at the time of hospitalization, hyperthermia is more often recorded before the labor and during childbirth. More frequently hyperthermia is fixed during the first 12 hours from the moment of membrane rupture. Furthermore, for these women are more typically serious complications of childbirth such as fetal distress, weakness of labor, and also more often there is a requirement for operative delivery. This investigation will help to offer individual management to women with preterm membrane rupture.

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Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease

Cited by 12 publications

References 43 publications

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review (Part 6): Correlation of PD-L1 Expression with the Status of Mismatch Repair System, BRCA, PTEN, and Other Genes

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review (Part 6): Correlation of PD-L1 Expression with the Status of Mismatch Repair System, BRCA, PTEN, and Other Genes

Rare case of infective aortitis with aortic rupture and cardiac tamponade in a young child

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