Kingella kingae endophthalmitis in an infant

Carden, Susan M.; Colville, Deb; Gonis, Gena; Gilbert, G. L.

doi:10.1111/j.1442-9071.1991.tb00664.x

Cited by 28 publications

(11 citation statements)

References 9 publications

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“…16 Among the remaining patients, 140 were diagnosed with bacteremia without a focus, 4 had bacteremia associated with a lower respiratory tract infection, and 8 had endocarditis. Meningitis, 17 ocular infections, 18 peritonitis, 19 and pericarditis 20 are rare manifestations of K kingae disease that have been described in other reports but were absent from this series.…”

Section: Epidemiology Of Invasive K Kingae Diseasementioning

confidence: 48%

Kingella kingae: An Emerging Pathogen in Young Children

2011

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Kingella kingae is being recognized increasingly as a common etiology of pediatric osteoarticular infections, bacteremia, and endocarditis, which reflects improved culture methods and use of nucleic acid-amplification techniques in clinical microbiology laboratories. K kingae colonizes the posterior pharynx of young children and is transmitted from child to child through close personal contact. Day care attendance increases the risk for colonization and transmission, and clusters of K kingae infections among day care center attendees have been reported. Key virulence factors in K kingae include type IV pili and a potent RTX toxin. In previously healthy children, >95% of K kingae infections are diagnosed between the ages of 6 and 48 months. Among children with underlying medical conditions, K kingae disease may occur at older ages as well. The clinical presentation of K kingae disease is often subtle and may be associated with normal levels of acute-phase reactants, which underscores the importance of a high index of suspicion. K kingae is usually susceptible to ß-lactam antibiotics, and infections typically respond well to medical treatment, with the exception of cases of endocarditis.

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Section: Epidemiology Of Invasive K Kingae Diseasementioning

confidence: 48%

Kingella kingae: An Emerging Pathogen in Young Children

2011

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“…Kingella kingae has been recovered from patients with different ocular infections, including palpebral abscess (34), keratitis (281,282), corneal ulcer (283), endophthalmitis (130,284), orbital cellulitis (285), and periorbital cellulitis (Yagupsky, unpublished data).…”

Section: Ocular Infectionsmentioning

confidence: 99%

Kingella kingae: Carriage, Transmission, and Disease

2015

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SUMMARY Kingella kingae is a common etiology of pediatric bacteremia and the leading agent of osteomyelitis and septic arthritis in children aged 6 to 36 months. This Gram-negative bacterium is carried asymptomatically in the oropharynx and disseminates by close interpersonal contact. The colonized epithelium is the source of bloodstream invasion and dissemination to distant sites, and certain clones show significant association with bacteremia, osteoarthritis, or endocarditis. Kingella kingae produces an RTX (repeat-in-toxin) toxin with broad-spectrum cytotoxicity that probably facilitates mucosal colonization and persistence of the organism in the bloodstream and deep body tissues. With the exception of patients with endocardial involvement, children with K. kingae diseases often show only mild symptoms and signs, necessitating clinical acumen. The isolation of K. kingae on routine solid media is suboptimal, and detection of the bacterium is significantly improved by inoculating exudates into blood culture bottles and the use of PCR-based assays. The organism is generally susceptible to antibiotics that are administered to young patients with joint and bone infections. β-Lactamase production is clonal, and the local prevalence of β-lactamase-producing strains is variable. If adequately and promptly treated, invasive K. kingae infections with no endocardial involvement usually run a benign clinical course.

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“…Almost one‐third of these originate from the Soroka University Medical Centre in Beer‐Sheva, Israel, 2 although cases have been described worldwide, including Australia. 3–7 We report four paediatric cases seen at the Gold Coast Hospital, Southport, Queensland, from 1992 to 1996 and review the literature of childhood Kingella kingae infections.…”

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confidence: 99%