Kinetics of the geometric isomerization of aqueous cis-diamminedichloroplatinum(II)

Hicks, Carolyn P.; Spiro, M.

doi:10.1007/bf02067945

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…In addition, significant inhibition of the isomerization of cisplatin in an aqueous solution by addition of Cl − ions has been reported [12]. In our experiments, 1 H NMR spectra of cisplatin in DMSO-d 6 showed that the cis-isomers, including species formed by the ligand exchange reaction with DMSO, were slowly isomerized to trans-isomers at 30°C.…”

Section: Stability Of the Two Platinum(ii) Species Of 1 With Cis-confmentioning

confidence: 82%

“…It has been reported that cisplatin undergoes rapid ligand exchange reactions and slow isomerization to the trans-isomer in dimethylsulfoxide and water [1,[11][12][13][14]. In addition, significant inhibition of the isomerization of cisplatin in an aqueous solution by addition of Cl − ions has been reported [12].…”

Section: Stability Of the Two Platinum(ii) Species Of 1 With Cis-confmentioning

confidence: 98%

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A Keggin-type polyoxotungstate-coordinated diplatinum(II) complex: Synthesis, characterization, and stability of the cis-platinum(II) moieties in dimethylsulfoxide and water

Katô

Kato

2011

Inorganic Chemistry Communications

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Section: Stability Of the Two Platinum(ii) Species Of 1 With Cis-confmentioning

confidence: 82%

Section: Stability Of the Two Platinum(ii) Species Of 1 With Cis-confmentioning

confidence: 98%

A Keggin-type polyoxotungstate-coordinated diplatinum(II) complex: Synthesis, characterization, and stability of the cis-platinum(II) moieties in dimethylsulfoxide and water

Katô

Kato

2011

Inorganic Chemistry Communications

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“…The thermodynamically stable form of the PtC12am 2 (am = cycloalkylamine) complexes is the trans isomer [103. Therefore, in aqueous KC1 solution cisplatin undergoes a conversion from the cis to the trans isomer with a half-life of 1.8 years at 37 °C [14].…”

Section: Preparation and Characterization Of The Complexesmentioning

confidence: 99%

Dichlorobis(cycloalkylamin)platin(II)-Komplexe. Struktur ? Wirkungsbeziehungen an der menschlichen MDA-MB-231 Brustkrebszellinie

Kritzenberger

Bernhardt²,

Gust³

et al. 1993

Monatsh Chem

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Summary. The syntheses of dichlorobis(cycloalkylamine)platinum(II) complexes with cis and transcycloalkytamine ligands 2 to cis-PtC12(CaHlsNH2)2 (3-8) and trans-PtC12-(CTH13NH2)2 (9) and trans-PtC12(CsH~sNH2)2 (10)] are described. The distinction between cis and trans isomers was achieved by ~H-NMR spectroscopy. The antitumor activity was determined on the cell proliferation of the human MDA-MB-231 breast cancer ceil line during long-term drug exposure. The complexes with small cycloalkylamine ligands (3-6) were inferior, those with large cycloalkylamine ligands were comparable (7) or superior (8) to cisplatin. Surprisingly, the cis/trans isomers 7/9 and 8/10 were equally active. All cycloalkylamine ligands were inactive. IR-spectroscopic studies showed that the size of the cycloalkylamine ring does not lead to significant differences in the Pt-C1 binding strength. Therefore it is assumed that the markedly stronger antitumor activity of the higher homologues, 7-10, is not the result of a faster reaction with bionucleophils such as DNA. A possible explanation of the high activity of 7-10 is the strong lipophilicity of the complexes. This assumption was confirmed by toxicity tests against confluent cultures. Keywords. cis-and trans-Dichlorobis(cycloalkylamine)platinum(II)complexes

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Cis-Platin, 1985 and 1986 (with a touch of 1987)

1987

Transition Met Chem

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Kinetics of the geometric isomerization of aqueous cis-diamminedichloroplatinum(II)

Cited by 3 publications

References 7 publications

A Keggin-type polyoxotungstate-coordinated diplatinum(II) complex: Synthesis, characterization, and stability of the cis-platinum(II) moieties in dimethylsulfoxide and water

A Keggin-type polyoxotungstate-coordinated diplatinum(II) complex: Synthesis, characterization, and stability of the cis-platinum(II) moieties in dimethylsulfoxide and water

Dichlorobis(cycloalkylamin)platin(II)-Komplexe. Struktur ? Wirkungsbeziehungen an der menschlichen MDA-MB-231 Brustkrebszellinie

Cis-Platin, 1985 and 1986 (with a touch of 1987)

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