Kinetics of the Elimination of Substances Injected Intravenously (Experiments With Creatinine)

Dominguez, R.; Goldblatt, Harry; Pomerene, Elizabeth

doi:10.1152/ajplegacy.1935.114.1.240

Cited by 16 publications

(6 citation statements)

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“…Injected creatinine has been shown to undergo complete excretion via the kidney only. This is in agreement with the studies of Dominguez, Goldblatt & Pomerene (1935) on dogs, and those of Dominguez & Pomerene (1945) on humans, in contrast to the findings of Beard (1943). This result is in accordance with the ingestion experiments, again indicating that creatinine entering the blood stream is entirely eliminated.…”

Section: I948supporting

confidence: 93%

The fate of ingested creatinine in the rat

Maw

1948

Biochemical Journal

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Section: I948supporting

confidence: 93%

The fate of ingested creatinine in the rat

Maw

1948

Biochemical Journal

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“…It follows that there is no obvious relationship between u galactose and s galactose ( Figure 2D), but there is a strong correlation between J galactose and s galactose (Figure 2E). These data are reminiscent of Rehberg's creatinine data ( Figure 1) and similar canine data involving xylose [134] or creatinine [135]. Data from experiments involving rabbits injected with creatinine [136,137] have been reported in less detail, but the relationship between J Cr and s Cr is just as clear.…”

Section: Decreasing S a (Ds A /Dt < 0)supporting

confidence: 73%

Expressing the quantity of urinary analytes: a discussion of some issues arising from the monitoring of the menstrual cycle

2020

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Practical domestic monitoring of the menstrual cycle requires measurements of urinary metabolites of reproductive hormones: oestrone glucuronide (E1G) and pregnanediol glucuronide (PdG). Data reported in the literature are expressed as (i) concentration, without or with either creatinine- or specific gravity correction, or (ii) excretion rates. This variation in such a fundamental issue prompts consideration of the relationships between the four measures. Because the menstrual cycle kinetics of E1G and PdG are complex, we consider measurements of urinary creatinine, urea, galactose, xylose and inulin which tend to be more stable. We show that uncorrected concentration measurements of these urinary analytes can be positively correlated, negatively correlated or uncorrelated with the serum concentration. Based on measurements of urinary creatinine concentrations, urinary specific gravity and creatinine excretion rates, we conclude that urinary analyte concentration are likely to be more reliable when creatinine-corrected rather than corrected using specific gravity, but that both are less reliable than measurements of the excretion rate. This has implications for the quantitation of any urinary analyte, but especially for the monitoring of the menstrual cycle in which changes in E1G and PdG from one day to the next can be physiologically significant for a woman monitoring her fertility.

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“…These data have been taken from an early publication (Dominguez et al, ). A dose of 6.6 g creatinine was given as an i.v.…”

Section: Data Analysis: a Worked Examplementioning

confidence: 99%