Kinetics of single and dual infection of calves with an Asian atypical bovine pestivirus and a highly virulent strain of bovine viral diarrhoea virus 1

Larska, Magdalena; Polak, M.P.; Riitho, Victor; Strong, Rebecca; Belák, Sándór; Alenius, Stefan; Uttenthal, Åse

doi:10.1016/j.cimid.2012.03.003

Cited by 34 publications

(42 citation statements)

References 35 publications

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“…The other hematological parameters remained within normal range. 20 The severity of clinical signs during the infection with HoBi-like viruses was compared to clinical signs following infection of cattle with strains of BVDV with typical and enhanced virulence. This study demonstrated that HoBi-like strains are transmissible between infected and sentinel calves, resulting in mild respiratory disease, transient pyrexia, and significant white blood cells depletion, which was similar to infection with a typically virulent BVDV strain.…”

Section: Experimental Infectionmentioning

confidence: 99%

“…1). These putative species include Giraffe virus, associated with an outbreak of mucosal-like disease in giraffes in the Nanyuki District of Kenya 32 ; Pronghorn virus, isolated from a blind pronghorn antelope in the United States 35 ; Bungowannah virus, detected in pigs following an outbreak of stillbirths and neonatal death in Australia 18 ; and a group of viruses variously referred to as HoBi-like, BVDV-3, or atypical pestiviruses, 20,24,28 which are the subject of the current review.…”

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confidence: 99%

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HoBi-like viruses

et al. 2013

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The genus Pestivirus is composed of 4 important pathogens of livestock: Bovine viral diarrhea virus 1 and 2 (BVDV-1 and BVDV-2), Classical swine fever virus (CSFV), and Border disease virus of sheep (BDV). BVDV are major pathogens of cattle, and infection results in significant economic loss worldwide. A new putative pestivirus species, tentatively called “HoBi-like,” “BVDV-3,” or “atypical pestiviruses,” was first identified in Europe in fetal bovine serum (FBS) imported from Brazil. HoBi-like viruses are related to BVDV at the genetic and antigenic levels. Further, the disease caused by these new viruses resembles clinical presentations historically associated with BVDV infection, including growth retardation, reduced milk production, respiratory disease, reduced reproductive performance, and increased mortality among young stock. Current BVDV diagnostic tests may fail to detect HoBi-like viruses or to differentiate between BVDV and HoBi-like viruses. Further, commercial tests for BVDV exposure, based on serological response, do not reliably detect HoBi-like virus exposure, and cross protection against HoBi-like viruses conferred by current BVDV vaccines is likely limited. As many HoBi-like viruses, characterized to date, were isolated from FBS originating from Brazil, it is assumed that the agent is probably widespread in Brazilian herds. Nevertheless, reports of natural infection in Southeast Asia and Europe demonstrate that these viruses are not restricted to South America. Increased demand for FBS has led to widespread distribution of FBS originating in HoBi-like virus endemic regions. The contamination of such FBS with HoBi-like viruses may lead to spread of this virus to other regions.

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Section: Experimental Infectionmentioning

confidence: 99%

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confidence: 99%

HoBi-like viruses

et al. 2013

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“…Alguns autores afirmam que o BVDV-3, em infecções naturais e experimentais, também está relacionado a síndromes respiratórias (Decaro et al 2011, 2012b, Larska et al 2012, abortos (Cortez et al 2006, Bianchi et al 2011, Decaro et al 2012a) e episódios de pirexia sem outras manifestações clínicas , de maneira que estas afecções são clinicamente semelhantes àquelas causadas pelo BVDV-1 e BVDV-2 (Decaro et al 2013, Weber et al 2014.…”

Section: Discussionunclassified

Detecção do virus ‘HoBi’-like (BVDV-3) em bovino no semiárido do Estado da Paraíba

et al. 2016

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RESUMO.-Objetivou-se descrever os aspectos clínicos e anatomopatológicos, e a identificação viral de um caso de infecção pelo vírus 'Hobi'-like (BVDV-3) em bovino do semiárido paraibano, Nordeste do Brasil. Um bovino, fêmea, três meses de idade, foi levado ao Hospital Veterinário da UFCG apresentando salivação, dificuldade de apreensão do teto, falta de apetite, fezes escuras e em pouca quantidade. Diante da piora do quadro clínico optou-se por sua eutaná-sia in extremis, seguida da realização da necropsia e coleta de material para histopatologia. Histologicamente, nas mucosas do trato digestivo, havia edema, degeneração balonosa, necrose e infiltrado inflamatório, que foi observado na face dorsal da língua e no seu epitélio mais profundo. The aim of this study was to describe the clinical and anatomopathological aspects, and the viral identification of a case of 'Hobi'-like (BVDV-3) vírus infection in cattle from the semiarid of Paraiba State, Northeastern Brazil. A female bovine, three months old, was sent to the UFCG's Veterinary Hospital presenting salivation, difficulty of ceiling seizure, lack of appetite, dark feces and in small amounts. Due to worsening of symptoms it was decided to in extremis euthanasia, followed by the necropsy and collection of material for histopathology. Histologically, in the mucous membranes of the digestive tract there were edema, ballooning degeneration, necrosis and inflammatory infiltrate, which was observed on the dorsal surface of the tongue and in its deepest epithelium. The immunohistochemical of skin biopsies of the extremity of the ear (ear notches) showed positive antigenic marking and by RT-PCR it was possible to detect viral RNA of BVDV in the serum, whose cytopathic effect in epithelial cells of bovine kidney lineage "Madin Darby bovine kidney" (MDBK)was not observed. The sequencing of the 5'NCR gene showed that the virus isolated was more related to 'Hobi'-like (BVDV-3). After confirming the diagnosis serum samples were collected from 23 animals for serology by indirect ELISA, and a seropositivity of 69.6% (16/23) was found. The identification of this new case of 'Hobi'-like infection in Paraiba reaffirms the need for regular BVDV monitoring in the region to early detection of infection in the herds and adoption of effective preventive and control measures.INDEX TERMS: Cattle, BVDV-3, pestivirus, viral identification.

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“…Nine of these samples were collected during the herd monitoring and were confirmed negative 3 weeks later on the second testing by real-time RT-PCR test confirming the TI status. The remaining 43 real-time RT-PCR positive serum samples came from 3 to 5 months old calves experimentally infected with BVDV1a as described previously (17). Samples were collected between 2 nd and 28 th d post-infection.…”

Section: Methodsmentioning

confidence: 99%

“…The probes were produced and labelled with fluorescent reporter FAM and VIC at the 5' ends and a quencher BHQ-1 at the 3' ends (Metabion International, Germany). Tenfold serial dilutions of in vitro transcribed 5'UTR RNA from Polish BVDV-1d isolate, cloned in the plasmid were included as the quantity standards as described previously (16,17).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of diagnostic methods to distinguish between calves persistently and transiently infected with bovine viral diarrhoea virus in respect to the presence of maternal antibodies

Larska

Kuta

Polak

2013

Bulletin of the Veterinary Institute in Pulawy

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Two issues concerning virus detection and identification of persistently infected (PI) cattle were analysed in the study: 1) interference by maternal antibodies and 2) discrimination between PI and transiently infected (TI) animals. Antigen ELISA and RT-PCR based methods were compared using serum samples from natural and experimental PI and TI calves. RT-PCR and realtime RT-PCR using primers within 5'UTR region were more sensitive in detecting PI animals than E rns and NS3 antigen capture

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Kinetics of single and dual infection of calves with an Asian atypical bovine pestivirus and a highly virulent strain of bovine viral diarrhoea virus 1

Cited by 34 publications

References 35 publications

HoBi-like viruses

HoBi-like viruses

Detecção do virus ‘HoBi’-like (BVDV-3) em bovino no semiárido do Estado da Paraíba

Evaluation of diagnostic methods to distinguish between calves persistently and transiently infected with bovine viral diarrhoea virus in respect to the presence of maternal antibodies

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