Abstract:A mathematical model, involving three consecutive first order reactions, has been applied to already existing experimental material in order to explain the hourly variation in serum levels obtained after administration of varying repeated doses of different preparations of p-aminosalicylic acid to human volunteers. The model closely agrees with the experimental data for all the orally administered preparations concerned, and the differences in blood levels for different preparations can be explained in terms o… Show more
“…However, the kinetics of elimination of aminosalicylic acid and its metabolites are very nearly linear up to a plasma concentration of approximately 110 mcg./ml. (8). Since the plasma concentrations encountered in this study did not exceed 85 mcg./ml.…”
“…However, the kinetics of elimination of aminosalicylic acid and its metabolites are very nearly linear up to a plasma concentration of approximately 110 mcg./ml. (8). Since the plasma concentrations encountered in this study did not exceed 85 mcg./ml.…”
The presystemic elimination of a large number of compounds is clearly established and represents a common and unavoidable cause of reduced bioavailability. The liver, intestine, and lungs have been identified as potential organs contributing to this effect but only in the case of the liver are sufficient data available for comprehensive analysis. More information on intestinal and pulmonary metabolism is clearly needed. Simple methods of kinetic analysis already exist, however, to assess the relative importance of these organs in presystemic elimination, especially in relation to the pre- and postabsorptive types of elimination that may occur.
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