Kinetics of Renin Inhibition by Sodium Houttuyfonate Analogs

Yuan, Lujiang; Wu, Jianping; Aluko, Rotimi E.; Yang, Xiaoli

doi:10.1271/bbb.60213

Cited by 30 publications

(30 citation statements)

References 28 publications

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“…In addition, the vasodepressor effect of baicalin has been previously reported in rats (Takizawa et al, 1998). The results of this study revealed that baicalin is more potent in renin inhibition than ACE inhibition, similar to the activity of sodium houttuyfonate analogs (Yuan et al, 2006), suggesting that baicalin, formerly an antimicrobial and antiviral agent, may interfere the RAS in vivo through renin and ACE inhibitions.…”

Section: Discussionsupporting

confidence: 65%

Inhibitory activities of baicalin against renin and angiotensin-converting enzyme

Deng

Aluko

Jin

et al. 2011

Pharmaceutical Biology

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Section: Discussionsupporting

confidence: 65%

Inhibitory activities of baicalin against renin and angiotensin-converting enzyme

Deng

Aluko

Jin

et al. 2011

Pharmaceutical Biology

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“…The sodium houttuy- fonate analogs showed renin inhibitory activity. 26) Among them, SHA-C14 (tetradecanoyl acetal sodium sulfate) showed the highest level of renin inhibition, with a K i value of 44 mM. This value is comparable to the K i value of SRI.…”

Section: Isolation Of Soybean Renin Inhibitormentioning

confidence: 79%

Isolation of Human Renin Inhibitor from Soybean: Soyasaponin I Is the Novel Human Renin Inhibitor in Soybean

Takahashi

Hori

Shinbo³

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…1A shows that the IC 50 values for the three ACE-inhibitory peptides ranged from 0.027-0.974 mM. WVYY had significantly (p<0.05) lowest IC 50 About two decades ago, most studies reporting renin-inhibitory properties mainly involved peptide analogues such as pepstatin, phospholipids and renin antibodies which had poor pharmacokinetic properties such as low bioavailability, high clearance and cost of their large-scale synthesis made them non-attractive as renin inhibitors for clinical use (Yuan, Wu, Aluko & Ye, 2006). Currently, there is only one known commercially available potent non-peptidic renin inhibitor (Aliskerin, IC 50 = 0.6 nM), thus justifying the on-going research for renin inhibitors from naturally occurring food sources.…”

Section: Ace-inhibitory Activities Of Hemp Seed Peptidesmentioning

confidence: 99%

Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides

Girgih

Malomo

et al. 2014

Journal of Functional Foods

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240

142

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The aim of this work was to produce enzymatic hemp seed protein hydrolysates (HPH) followed by bioassay guided fractionation to identify antioxidant and antihypertensive peptides. Therefore, simulated gastrointestinal digestion of isolated hemp seed proteins was conducted using consecutive actions of pepsin and pancreatin to produce HPH, which was then separated by membrane ultrafiltration to obtain peptide sizes of <1, 1-3, 3-5, and 5-10 kDa. Evaluation of HPH and its membrane fractions for antioxidant and antihypertensive properties showed that they significantly (P<0.05) scavenged radicals, reduced and strongly chelated metal ions as well as inhibited lipid oxidation. During a 24-hr test, the HPH reduced systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR) after oral administration by a maximum of -30 mmHg when compared to -15 mmHg for the membrane fractions.To reduce production cost, hemp seed protein meal (HPM) was directly hydrolyzed to a protein hydrolysate (HMH) and was shown to also reduce SBP during 4-8 weeks of dietary feeding. The attenuation of SBP correlated to suppressed plasma levels (0.047-0.059 U/mL and 0.040-0.054 µg/mL) of angiotensin converting enzyme (ACE) and renin, respectively, when compared to the control rats (0.123 U/mL and 0.151 µg/mL). A total of 23 peptides were identified to be present in the HPH. WVYY and PSLPA showed superior in vitro antioxidant properties, while ACE activity was inhibited by WYT (89%), WVYY (91%) and PSLPA (90%). Renin activity was inhibited by WYT (77%), SVYT (87%) and IPAGV (75%). However, oral administration to SHR showed that the pentapeptides (PSLPA and IPAGV) were more effective SBP-reducing agents (-40 mm Hg) when compared to the tri-(-13 mmHg) and tetrapeptides (-36 mmHg). These results

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Kinetics of Renin Inhibition by Sodium Houttuyfonate Analogs

Cited by 30 publications

References 28 publications

Inhibitory activities of baicalin against renin and angiotensin-converting enzyme

Inhibitory activities of baicalin against renin and angiotensin-converting enzyme

Isolation of Human Renin Inhibitor from Soybean: Soyasaponin I Is the Novel Human Renin Inhibitor in Soybean

Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides

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