Kinetics of Plasma Cytokine Levels in Children Hyposensitized With Wasp Venom

Ponvert, C.; Courvoisier, Claire Le; Weill, Bernard; Bloch, Evelyne; Paupe, J; Scheinmann, P.

doi:10.1006/cyto.2001.0926

Cited by 4 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results correspond with results of Ponvert et al 13 study. The authors examined plasma level of CCL5/RANTES in children who were treated with rush immunotherapy.…”

Section: Discussionsupporting

confidence: 94%

“…RANTES along with other chemokines was found in nasal tissue of allergic rhinitis patients presenting higher concentration in severe compare to mild severity of the diseases and controls 21 . There are only few studies investigating CCL5/RANTES in serum of allergic patients under immunotherapy especially with insect vaccines [13][14][15] .…”

Section: Discussionmentioning

confidence: 99%

“…They found transiently elevated plasma level at Day 2 and decreased at the Day 4. The authors suggested that plasma levels of CCL5/RANTES could reflect the reactivity of the children to wasp venom, and could be even predictive of the efficiency of VIT 13 .…”

Section: Discussionmentioning

confidence: 99%

“…Multiple molecular studies of non-CF polyps have established that CCL5/ RANTES may play an important role in nasal polyposis 12 . Data on the role of CCL5/RANTES in Hymenoptera venom allergy are scarce and related to kinetics of RANTES plasma levels in children in the first days of rush VIT, or in the first 2 month of VIT in nine children or expression of mRNA for RANTES and cytokine in skin biopsies of patients undergoing wasp VIT [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of venom immunotherapy on serum level of CCL5/RANTES in patients withHymenopteravenom allergy

Gawlik

Glück

Jawor

et al. 2015

Immunopharmacology and Immunotoxicology

View full text Add to dashboard Cite

Hymenoptera venoms are known to cause life-threatening IgE-mediated anaphylactic reactions in allergic individuals. Venom immunotherapy is a recommended treatment of insect allergy with still the mechanism not being completely understood. We decided to assess the serum CCL5/RANTES level in patients who experienced severe anaphylactic reaction to Hymenoptera venom and to find out changes in the course of immunotherapy. Twenty patients (9 men, 11 women, mean age: 31.91 ± 7.63 years) with history of anaphylactic reaction after insect sting were included into the study. Diagnosis was made according to sIgE and skin tests. All of them were enrolled into rush venom immunotherapy with bee or wasp venom extracts (Pharmalgen, ALK-Abello, Horsholm, Denmark). Serum levels of CCL5/RANTES were measured using a commercially available ELISA kit (R&D Systems, Minneapolis, MN). CCL5/RANTES serum concentration are higher in insect venom allergic patients than in healthy controls (887.5 ± 322.77 versus 387.27 ± 85.11 pg/ml). Serum concentration of CCL5/RANTES in insect venom allergic patient was significantly reduced in the course of allergen immunotherapy already after 6 days of vaccination (887.5 ± 322.77 versus 567.32 ± 92.16 pg/ml). CCL5/RANTES serum doesn't correlate with specific IgE. Chemokine CCL5/RANTES participates in allergic inflammation induced by Hymenoptera venom allergens. Specific immunotherapy reduces chemokine CCL5/RANTES serum level already after initial days of venom immunotherapy.

show abstract

“…Our results correspond with results of Ponvert et al 13 study. The authors examined plasma level of CCL5/RANTES in children who were treated with rush immunotherapy.…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of venom immunotherapy on serum level of CCL5/RANTES in patients withHymenopteravenom allergy

Gawlik

Glück

Jawor

et al. 2015

Immunopharmacology and Immunotoxicology

View full text Add to dashboard Cite

show abstract

“…Yi et al [ 13 ] showed that the ant venom from Solenopsis invicta acts on the nitric oxide synthase enzyme of murine macrophages, interfering in the production and release of this mediator. Similar effects were demonstrated in macrophages exposed to the venom from other animals such as scorpions, wasps, bees and spiders [ 14 , 15 , 16 , 17 ]. In addition, some venom presents hemolytic and/or cytotoxic activity leading to death, usually by apoptosis in human cells [ 16 , 18 , 19 ].…”

Section: Introductionsupporting

confidence: 63%

Analysis of Protein Composition and Bioactivity of Neoponera villosa Venom (Hymenoptera: Formicidae)

Pessoa

Silva

Dias

et al. 2016

IJMS

View full text Add to dashboard Cite

Ants cause a series of accidents involving humans. Such accidents generate different reactions in the body, ranging from a mild irritation at the bite site to anaphylactic shock, and these reactions depend on the mechanism of action of the venom. The study of animal venom is a science known as venomics. Through venomics, the composition of the venom of several ant species has already been characterized and their biological activities described. Thus, the aim of this study was to evaluate the protein composition and biological activities (hemolytic and immunostimulatory) of the venom of Neoponera villosa (N. villosa), an ant widely distributed in South America. The protein composition was evaluated by proteomic techniques, such as two-dimensional electrophoresis. To assess the biological activity, hemolysis assay was carried out and cytokines were quantified after exposure of macrophages to the venom. The venom of N. villosa has a profile composed of 145 proteins, including structural and metabolic components (e.g., tubulin and ATPase), allergenic and immunomodulatory proteins (arginine kinase and heat shock proteins (HSPs)), protective proteins of venom (superoxide dismutase (SOD) and catalase) and tissue degradation proteins (hyaluronidase and phospholipase A2). The venom was able to induce hemolysis in human erythrocytes and also induced release of both pro-inflammatory cytokines, as the anti-inflammatory cytokine release by murine macrophages. These results allow better understanding of the composition and complexity of N. villosa venom in the human body, as well as the possible mechanisms of action after the bite.

show abstract

Favorable hymenoptera sting reactions during childhood may have enabled transmission of responsible allergic genotype into generations

Mingomataj

2006

Medical Hypotheses

View full text Add to dashboard Cite

Kinetics of Plasma Cytokine Levels in Children Hyposensitized With Wasp Venom

Cited by 4 publications

References 11 publications

Effects of venom immunotherapy on serum level of CCL5/RANTES in patients withHymenopteravenom allergy

Effects of venom immunotherapy on serum level of CCL5/RANTES in patients withHymenopteravenom allergy

Analysis of Protein Composition and Bioactivity of Neoponera villosa Venom (Hymenoptera: Formicidae)

Favorable hymenoptera sting reactions during childhood may have enabled transmission of responsible allergic genotype into generations

Contact Info

Product

Resources

About