Kinetics of liposome disintegration from foam film studies: Effect of the lipid bilayer phase state

Vassilieff, C.S.; Panaı̈otov, I.; Manev, Emil D.; Proust, J. E.; Ivanova, Tz.

doi:10.1016/0301-4622(95)00089-5

Cited by 44 publications

(22 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism of adhesion and spreading of vesicles on a mercury surface, as shown in Fig. 8, is similar to that observed for membrane fusion 186,187 and for membrane adhesion‐spreading on other substrates 154,155 . The data that can be obtained from these measurements cover most of the important characteristics of the liposomes and of the vesicle‐mercury interaction.…”

Section: Discussionsupporting

confidence: 75%

See 1 more Smart Citation

The Electrochemistry of Liposomes

Hernández

Scholz

2008

Israel Journal of Chemistry

View full text Add to dashboard Cite

This review aims to summarize the current state of research concerning the interaction of electrodes with liposomes suspended in solutions. Main attention is given to the complex mechanism of adhesion and spreading of liposomes on mercury electrodes. That mechanism can be studied with the help of chronoamperometry, where each adhesion‐spreading event appears as a capacitive current spike. Integration of these spikes produces charge versus time transients that can be modeled and simulated, revealing the details of the multi‐step adhesion‐spreading process. Whereas the number of spikes per time mirrors the macro‐kinetics, the analysis of the time behavior of each spike mirrors the micro‐kinetics of each adhesion‐spreading event. The reviewed studies show that this approach provides a new tool to study the properties of liposome membranes. The adhesion‐spreading of liposomes on mercury electrodes has strong similarities to the process of vesicle fusion, which makes these studies a biomimetic model allowing one to deduce the effects of foreign molecules in bilayer membranes.

show abstract

Section: Discussionsupporting

confidence: 75%

“…In the first step, the bilayer portion in contact with the interface is rearranged. In the second step, the vesicle spreads on the interface, forming a lipid monolayer 154,155 . The limiting (slowest) step will depend on the nature of the substrate.…”

Section: Liposomes and Electrochemistrymentioning

confidence: 99%

The Electrochemistry of Liposomes

Hernández

Scholz

2008

Israel Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…Thus, adsorption at the air/water interface of the essentially insoluble long-chain PLs involves first a diffusion step of the vesicles to the interface, followed by a reorganization of the PLs of the vesicles to form the interfacial film. [18][19][20] The nature of this film, whether a true monolayer [21,22] or an inhomogeneous superficial mesophase (including bilayers or more complex structures playing the role of "surface-associated reservoirs"), [18,[23][24][25] is still being debated.…”

Section: Introductionmentioning

confidence: 99%

A Nonpolar, Nonamphiphilic Molecule Can Accelerate Adsorption of Phospholipids and Lower Their Surface Tension at the Air/Water Interface

et al. 2011

View full text Add to dashboard Cite

The adsorption dynamics of a series of phospholipids (PLs) at the interface between an aqueous solution or dispersion of the PL and a gas phase containing the nonpolar, nonamphiphilic linear perfluorocarbon perfluorohexane (PFH) was studied by bubble profile analysis tensiometry. The PLs investigated were dioctanoylphosphatidylcholine (DiC(8)-PC), dilaurylphosphatidylcholine, dimyristoylphosphatidylcholine, and dipalmitoylphosphatidylcholine. The gas phase consisted of air or air saturated with PFH. The perfluorocarbon gas was found to have an unexpected, strong effect on both the adsorption rate and the equilibrium interfacial tension (γ(eq)) of the PLs. First, for all of the PLs, and at all concentrations investigated, the γ(eq) values were significantly lower (by up to 10 mN m(-1)) when PFH was present in the gas phase. The efficacy of PFH in decreasing γ(eq) depends on the ability of PLs to form micelles or vesicles in water. For vesicles, it also depends on the gel or fluid state of the membranes. Second, the adsorption rates of all the PLs at the interface (as assessed by the time required for the initial interfacial tension to be reduced by 30%) are significantly accelerated (by up to fivefold) by the presence of PFH for the lower PL concentrations. Both the surface-tension reducing effect and the adsorption rate increasing effect establish that PFH has a strong interaction with the PL monolayer and acts as a cosurfactant at the interface, despite the absence of any amphiphilic character. Fitting the adsorption profiles of DiC(8)-PC at the PFH-saturated air/aqueous solution interface with the modified Frumkin model indicated that the PFH molecule lay horizontally at the interface.

show abstract

“…Amongst the wide number of surfactants and surfactant aggregates, one particular type of structure, whose adsorption behavior to the air-water interface has been studied in great detail, are vesicles, especially vesicle dispersions of phospholipids. Owing to their physiological relevance, the spreading behavior of few phospholipids, also named as lung surfactants, has been subject to several studies [5][6][7][8][9]. While the exact mechanism of adsorption is still a matter for debate today [10][11][12][13], these studies have mostly shown that the adsorption behavior of surfactant from vesicle structures is strongly dependent on the physical state of the vesicle membrane [14][15][16].…”

Section: Introductionmentioning

confidence: 99%