Kinetics of initiation of the third generation Grubbs metathesis catalyst: convergent associative and dissociative pathways

Abstract

The monopyridyl form of the Grubbs III catalyst initiates rapidly, via both dissociative and associative pathways.

It is Better with Salt: Aqueous Ring-Opening Metathesis Polymerization at Neutral pH

“…Benzaldehyde and benzyl alcohol were also detected as byproducts of catalyst decomposition, both of which were presumably derived from the styrenic benzylidene ligand. 57 It should also be noted that the formation of Ru hydride species could also be detected after incubation of G3 with NaOH for 2 h ( Figure S15 ), suggesting a probable mechanism of decomposition for the Ru-(OH) n species. 47 , 58 , 59 The effect of chloride ligand exchange on complex absorption was also investigated.…”

Investigation of interaction between boronic acids and sugar: effect of structural change of sugars on binding affinity using steady state and time resolved fluorescence spectroscopy and molecular docking

“…Equilibrium composition in aqueous medium at 25 °C in sucrose is 6% β-furanose and 10% α-furanose, in D-galactose it is 8.4% α-furanose and 15.5% β-furanose. The only significant forms in sucrose are α and β pyranose forms whereas α and β furanose forms in water are only about 0.08% at 31 °C 30 , 44 , 45 , 46 , 47 ]. Our study also shows the effect of these changes in structure on the binding process.…”

“…Boronic acids are continuing to gain interest in scaffold designing of sensors for carbohydrate cognition because of their high sugar intrinsic affinity and reversible rapid equilibrium. Even in simple cells, carbohydrates are found to be endogenous and vital in many of the biochemical processes [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Also, they are often linked to proteins that affect activity and cell surfaces.…”

“…Due to their ability of binding tightly with diols which are found in sugar molecules, boronic acids are used for designing chemo sensors. It has a covalent reaction with 1,2 or 1,3-diols and forms cyclic esters of five or six members in aqueous solution which is a reversible complexation, and that makes it an ideal interaction in designing of sensors [ 44 , 45 , 46 , 47 ]. For determining compounds that contain diol, efforts based on interaction of boronic acid and diol are being made to focus on developing fluorometric and colorimetric sensors [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

“…Two esters are produced as a result of diol binding in tetrahedral or trigonal form. Various factors like concentration and nature of buffer, pH of medium, temperature, dihedral angle of diol, the and pKa value of formed ester, influences the process of binding [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. To have a quantitative study of process of binding, calculation of binding constant, here association constant (Ka) is important.…”