Kinetics of IgG antibody to cytomegalovirus (CMV) after birth and seroprevalence of anti-CMV IgG in Chinese children

Chen, Jie; Hu, Lingqing; Wu, Meiling; Zhong, Tianying; Zhou, Yi‐Hua; Hu, Yali

doi:10.1186/1743-422x-9-304

Cited by 39 publications

(46 citation statements)

References 28 publications

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“…Our findings from the pregnant women in Jiangsu province, having comparable economical status and residential density, were in accordance with the previous study conducted in Beijing, China, where the prevalence of anti-CMV IgG and IgM in 4692 childbearing-age or pregnant women was 92.5% and 1.8% respectively [6]. The seroprevalence in the current study is also comparable to that (96.4%) in pregnant women from Nanjing, the capital of Jiangsu province [19]. Thus, the high seroprevalence indicates that CMV infection is now universal in Chinese pregnant women.…”

Section: Discussionsupporting

confidence: 91%

Cytomegalovirus Seroprevalence in Pregnant Women and Association with Adverse Pregnancy/Neonatal Outcomes in Jiangsu Province, China

Zhang

Hu²,

Chen

et al. 2014

PLoS ONE

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BackgroundIn this study, we aimed to determine the provincial population-based seroprevalence in pregnant women and to further explore the association of maternal CMV infection status and adverse pregnancy/neonatal/growth outcomes in Jiangsu, China.MethodsIn this case-control study, the sera from 527 pregnant women with adverse pregnancy/neonatal outcomes and 496 mothers of healthy infants in Jiangsu Province, collected at gestation age of 15–20 weeks, were tested for anti-CMV IgG, IgM and IgG avidity. Adverse pregnancy/neonatal outcomes were identified based on pregnancy/neonatal outcomes.ResultsThe overall seroprevalence of anti-CMV IgG was 98.7%, with 99.4% and 98.0% in the case and control groups, respectively (P = 0.039). The prevalence of anti-CMV IgG+/IgM+, was higher in the case group than that in the control group (3.8% vs. 1.6%, P = 0.033). Anti-CMV IgG avidity assay showed that none in the control group were primarily infected, but five (0.9%) in the case group underwent primary infection (P = 0.084); all five infants of these women presented severe adverse neonatal/growth outcomes. Exact logistic regression analysis showed that anti-CMV IgG+/IgM+ was associated with adverse pregnancy/neonatal/growth outcomes (aOR = 2.44, 95% CI 1.01–6.48, P = 0.047). Maternal low education level and prior abnormal pregnancies also were risk factors for adverse pregnancy/neonatal outcomes.ConclusionsIn populations with very high prevalence of latent CMV infection, active maternal CMV infection during pregnancy might be a risk factor for adverse pregnancy/neonatal outcomes.

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Section: Discussionsupporting

confidence: 91%

Cytomegalovirus Seroprevalence in Pregnant Women and Association with Adverse Pregnancy/Neonatal Outcomes in Jiangsu Province, China

Zhang

Hu²,

Chen

et al. 2014

PLoS ONE

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“…At 24 weeks, Ͻ20% of infants had IgG of high avidity, which could represent either transplacentally acquired maternal antibody or already mature infant antibody from primary infection. Our results indicate that most maternal antibody has waned by 6 months, consistent with a study from China suggesting that the maternally acquired anti-CMV IgG in infants disappears before 8 months of age (24); similarly, a study from Germany concluded that maternal antibody against CMV decayed by 12 months (25).…”

Section: Discussionsupporting

confidence: 79%

Cytomegalovirus IgG Level and Avidity in Breastfeeding Infants of HIV-Infected Mothers in Malawi

Kourtis¹,

Wiener²,

Chang³

et al. 2015

Clin. Vaccine Immunol.

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dCytomegalovirus (CMV) infection is common among infants of HIV-infected mothers in resource-limited settings. We examined the prevalence and timing of infant CMV infection during the first year of life using IgG antibody and avidity among HIVexposed infants in Malawi and correlated the results with the presence of detectable CMV DNA in the blood. The Breastfeeding, Antiretrovirals and Nutrition (BAN) study randomized 2,369 mothers and their infants to maternal antiretrovirals, infant nevirapine, or neither for 28 weeks of breastfeeding, followed by weaning. Stored plasma specimens were tested for CMV IgG and antibody avidity from a random subset of infants who had been previously tested with blood CMV PCR and had available specimens at birth and at 24 and 48 weeks of age. Ninety-four of 127 infants ( C ytomegalovirus (CMV) infection is the most common congenital infection, with an estimated prevalence of Ͼ1% in resource-limited settings (1, 2). Approximately 10 to 20% of congenital CMV infections result in permanent deficits, including sensorineural hearing loss, vision loss, and mental and developmental disability (3). The postnatal acquisition of CMV can occur through horizontal transmission and through breastfeeding, with a high probability of transmission in infants fed with breast milk containing infectious virus (4, 5). The infants of HIV-infected mothers may have higher rates of congenital CMV infection, particularly if the mothers are immunocompromised (6). While postnatal transmission is thought to be generally benign in healthy full-term infants, premature infants or other groups of immunocompromised infants are at risk for more extensive disease and may also experience long-term cognitive delays (7-9).While the increased morbidity and mortality among infants coinfected with HIV and CMV is well recognized (10-14), HIVexposed but uninfected infants may also be at increased risk for morbidity and mortality from CMV infection (15-17). A study in Zambia found that HIV-exposed infants who were CMV seropositive had decreased length for age, reduced head size, and lower psychomotor development than those who were CMV uninfected (5). HIV is endemic in many African countries and the CMV childhood infection burden is high, which may have a substantial impact on child health in the region. It is therefore important to examine when infants acquire primary CMV infection in such settings.In a previous analysis, we reported, using blood CMV PCR, that Ͼ70% of infants of HIV-infected mothers had acquired CMV infection by 24 weeks of age (18). Given that blood is not the optimal sample source for CMV detection, it is possible that our findings underestimated the true incidence of CMV acquisition in the infants. We thus additionally performed CMV IgG antibody titer and avidity testing in the infant plasma specimens at different points in the infants' first year of life. The objectives of this study were to comprehensively assess the rate of CMV acquisition and to further characterize the time of CMV infection in HIV-exp...

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“…Human cytomegalovirus (HCMV) is a ubiquitous, highly hostspecific herpesvirus that causes severe, sometimes life-threatening disease in congenitally infected newborns as well as in immunocompromised individuals such as bone marrow allograft transplant recipients and AIDS patients (Boeckh and Geballe, 2011;Chen et al, 2012).The ability to reactivate with high viral load from latency in immunocompromised or immunosuppressed hosts endowed HCMV with high pathogenesis (Slobedman et al, 2004). To date, no effective vaccine or antiviral drugs is available to prevent or treat HCMV infection.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome altered by latent human cytomegalovirus infection on THP-1 cells using RNA-seq

Zhang

Lai

Lou

et al. 2016

Gene

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Human cytomegalovirus (HCMV) has been recognized as a cause of severe, sometimes life-threatening disease in congenitally infected newborns as well as in immunocompromised individuals. However, the molecular mechanisms of the host-virus interaction remain poorly understood. Here, we profiled the expression of mRNAs and long noncoding RNAs (lncRNAs) in THP-1 cells using the emerging RNA-seq to investigate the transcriptional changes during HCMV latent infection. At 4 days post HCMV infection, a total of 169,008,624 sequence reads and 180,616 transcripts were obtained, respectively. Of these transcripts, 1,354 noncoding genes and 12,952 protein-coding genes were observed in Refseq database. Differential gene expression analysis identified 2,153 differentially expressed genes (DEGs) between HCMV-infected and mock-infected THP-1 cells, including 1,098 up-regulated genes and 1,055 down-regulated genes. These regulated genes were involved in pathways of apoptosis, inflammatory response and cell cycle progression, all of which may be implicated in viral pathogenesis. In addition, 646 lncRNAs (208 known lncRNAs and 438 novel lncRNAs) were upregulated and 424 (140 known and 284 novel) were downregulated in infected THP-1 cells. These findings have provided a dynamic scenario of DE candidate genes and lncRNAs at the virus-host interface and clearly warrant further experimental investigation associated with HCMV infection.

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Kinetics of IgG antibody to cytomegalovirus (CMV) after birth and seroprevalence of anti-CMV IgG in Chinese children

Cited by 39 publications

References 28 publications

Cytomegalovirus Seroprevalence in Pregnant Women and Association with Adverse Pregnancy/Neonatal Outcomes in Jiangsu Province, China

Cytomegalovirus Seroprevalence in Pregnant Women and Association with Adverse Pregnancy/Neonatal Outcomes in Jiangsu Province, China

Cytomegalovirus IgG Level and Avidity in Breastfeeding Infants of HIV-Infected Mothers in Malawi

Transcriptome altered by latent human cytomegalovirus infection on THP-1 cells using RNA-seq

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