Kinetics of <i>Torque Teno</i> virus DNA in stools may predict occurrence of acute intestinal graft versus host disease early after allogeneic hematopoietic stem cell transplantation

Bueno, Felipe; Albert, Eliseo; Piñana, José Luís; Pérez, Ariadna; Úbeda, Carlos; Gómez, María Dolores; Hernández‐Boluda, Juan Carlos; Gonzalez‐Barberá, Eva María; Montoro, Juan; Giménez, Estela; Guerreiro, Manuel; Balaguer‐Roselló, Aitana; Hernani, Rafael; Sanz, Jaime; Solano, Carlos; Navarro, David

doi:10.1111/tid.13507

Cited by 7 publications

(8 citation statements)

References 23 publications

(70 reference statements)

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“…quantitated TTV DNA by real‐time PCR in paired stool samples collected at a median of 2 days prior to cell infusion and at a median of 14 days after allo‐HSCT. The presence of a falling trajectory (decrease in TTV DNA load > 0.5 log 10 copies/0.1 g) in paired pre‐transplant and post‐transplant stool specimens was independently associated with the occurrence of acute intestinal GvHD 100 …”

Section: Torque Teno Virus In Allogeneic Hematopoietic Stem‐cell Tran...mentioning

confidence: 97%

“…Interestingly, some preliminary studies suggest that non‐blood specimens, such as saliva or stools, may be alternatively used for the TTV monitoring 100,101 . Bueno et al.…”

Section: Torque Teno Virus In Allogeneic Hematopoietic Stem‐cell Tran...mentioning

confidence: 99%

“…100,101 Bueno et al quantitated TTV DNA by real-time PCR in paired stool samples collected at a median of 2 days prior to cell infusion and at a median of 14 days after allo-HSCT. The presence of a falling trajectory (decrease in TTV DNA load > 0.5 log 10 copies/0.1 g) in paired pre-transplant and post-transplant stool specimens was independently associated with the occurrence of acute intestinal GvHD 100. As observed, the translation of TTV DNA kinetics as a marker of immune competence among allo-HSCT recipients is far more complex than in their SOT counterparts.…”

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confidence: 99%

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Viruses, friends, and foes: The case of Torque Teno Virus and the net state of immunosuppression

Redondo

Navarro

Paz‐Artal

et al. 2022

Transplant Infectious Dis

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Section: Torque Teno Virus In Allogeneic Hematopoietic Stem‐cell Tran...mentioning

confidence: 97%

“…Interestingly, some preliminary studies suggest that non‐blood specimens, such as saliva or stools, may be alternatively used for the TTV monitoring 100,101 . Bueno et al.…”

Section: Torque Teno Virus In Allogeneic Hematopoietic Stem‐cell Tran...mentioning

confidence: 99%

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confidence: 99%

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Viruses, friends, and foes: The case of Torque Teno Virus and the net state of immunosuppression

Redondo

Navarro

Paz‐Artal

et al. 2022

Transplant Infectious Dis

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“…11 Most importantly, TTV is not affected by conventional antiviral drug therapy. 47 Previous studies in KT, 32,34 liver transplant, 48 lung transplant, [49][50][51] and stem cell transplant 52,53 suggested that TTV DNA load closely correlated with the risk of allograft rejection and infectious diseases. Jaksch et al described that TTV levels >1 × 10 7 copies/mL was linked with a lower risk of rejection.…”

Section: Discussionmentioning

confidence: 99%

Torque‐teno virus for the prediction of graft rejection and infection disease after kidney transplantation: A systematic review and meta‐analysis

Zeng

Tang

Lin

et al. 2023

Journal of Medical Virology

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Torque teno virus (TTV) is a promising novel marker for quantifying the immune function in solid organ recipients, whose diagnostic accuracy of acute rejection (AR) and infection after kidney transplantation (KT) has not been evaluated. We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of TTV for discriminating AR and infection after KT. Eleven studies were included in the meta-analysis. Seven studies focused on the diagnostic accuracy of TTV for AR, and the pooled analysis indicated patients who developed AR had a significant lower TTV viral DNA load (log 10 copies/mL, MD: −0.74, p < 0.01). The pooled sensitivity, specificity, and area under the receiver operating characteristics curve for TTV in AR differentiation were 0.61 (0.36−0.82), 0.81 (0.64−0.91), and 0.79 (0.75−0.82), respectively. The overall diagnostic odds ratio (DOR) was 6.74(2.60−17.50), positive likelihood ratio (PLR) was 3.22 (1.75−5.95), and negative likelihood ratio (NLR) was 0.48 (0.27−0.84), respectively. Similarly, seven studies investigated the infection discrimination and found that patients who subsequently developed posttransplant infection had higher plasma TTV DNA loads (log 10 copies/ mL, MD: 0.65; p < 0.01) than those remaiing infection-free. Pooled sensitivity, specificity, and area under the receiver operating characteristics curve for TTV in infection differentiation were 0.72 (0.39−0.91), 0.57 (0.30−0.80), and 0.68 (0.64−0.72), respectively. The overall DOR was 3.28 (95% confidence interval [CI]: 2.08−5.17), the pooled PLR and NLR were 1.65 (95% CI: 1.25−2.18) and 0.50 (95% CI: 0.29−0.86), respectively. TTV might be a modest indicator for risk stratification of AR after KT, but it is a poor to discriminate posttransplant infection.

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“…Our data suggested that this might also be the case in critically ill COVID-19 patients regarding nosocomial bloodstream infections and VAP. The potential relevance of this finding stems on two assumptions that are debatable: (i) most if not all adults are chronically infected by one or more TTV species that may access the blood compartment with no apparent clinical consequences [2] ; (ii) the lack of TTV DNAemia detection, even in healthy individuals, may be due to analytical drawbacks (namely, insufficient sensitivity of current PCR assays), the existence of sanctuaries of viral persistence in organ and tissues other than peripheral blood [ 2 , 4 , 34 ], or both; natural or iatrogenic immunosuppression may decrease immune surveillance of TTV in virus-persistence sites allowing TTV DNAemia to become detectable [2] . Moreover, an increased risk of subsequent infections was observed for patients displaying detectable TTV DNA in plasma or exhibiting TTV DNA load ≥3.3 log10 copies/ml within the first week since ICU admission.…”

Section: Discussionmentioning

confidence: 99%

Monitoring of Torque Teno virus DNAemia in critically ill COVID-19 patients: May it help to predict clinical outcomes?

Forqué¹,

Albert²,

Giménez³

et al. 2022

Journal of Clinical Virology

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Background : Torque teno virus (TTV) DNA load in plasma directly associates with the net state of immunosuppression and inflammation in different clinical settings, including transplantation and chronic inflammatory diseases. Objectives : We investigated whether plasma TTV DNA load may predict the occurrence of certain infectious events and overall mortality in critically ill COVID-19 patients. Patients and Methods : 50 patients (median age, 65.5 years) were recruited. TTV DNA load was quantitated in serial plasma specimens by real-time PCR. Serum levels of interleukin-6, C-reactive protein, ferritin, lactate dehydrogenase, Gamma-Glutamyl Transferase (GGT), alanine transaminase (ALT) and aspartate transaminase (AST) and absolute lymphocyte counts (ALC) in paired specimens were available. Nosocomial bloodstream infections and ventilator-associated pneumonia and overall mortality were the clinical outcomes. Results : TTV DNA was detected in 38 patients (76%). A weak inverse correlation (Rho=-0.28; P = 0.004) was observed between TTV DNA loads and ALC. No direct correlation was found between TTV DNA load and serum levels of any of the above biomarkers. Patients with detectable TTV DNA had an increased risk of subsequently developing infectious events (HR 9.28; 95% CI, 1.29–69.5; P = 0.03). A trend ( P = 0.05) towards higher TTV DNA area under a curve between days 7 and 17 after ICU admission (AUC 7–17 ) was observed in patients who died, as compared to survivors. Conclusion : Our findings suggested that plasma TTV DNA load monitoring may be helpful for predicting the occurrence of severe nosocomial infections and mortality in critically ill COVID-19 patients.

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Kinetics of Torque Teno virus DNA in stools may predict occurrence of acute intestinal graft versus host disease early after allogeneic hematopoietic stem cell transplantation

Cited by 7 publications

References 23 publications

Viruses, friends, and foes: The case of Torque Teno Virus and the net state of immunosuppression

Viruses, friends, and foes: The case of Torque Teno Virus and the net state of immunosuppression

Torque‐teno virus for the prediction of graft rejection and infection disease after kidney transplantation: A systematic review and meta‐analysis

Monitoring of Torque Teno virus DNAemia in critically ill COVID-19 patients: May it help to predict clinical outcomes?

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