Kinetics of hydrolysis of acetyl, valeroyl and nicotinoyl acyl derivatives of stobadine

Stankovicová, M; Bezáková, Ž; Beneš, L

doi:10.1016/s0024-3205(99)00466-x

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Prodrugs That Rely (Mostly) On Enzymatic Activation1

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2008

2022

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Cited by 3 publications

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“…One synthetic amide prodrug type system that has been extensively studied are the N -acyl derivatives of allopurinol, which are more lipophilic than the parent drug, while at the same time being in some cases more water soluble [ 24 ]. The acetyl, veleroyl and nicotinoyl amides of stobadine ( 3 ) are highly lipophilic and penetrate the BBB [ 25 ].…”

Section: Prodrugs That Rely (Mostly) On Enzymatic Activationmentioning

confidence: 99%

Prodrugs for Amines

2008

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The purpose of this work is to review the published strategies for the production of prodrugs of amines. The review is divided in two main groups of approaches: those that rely on enzymatic activation and those that take advantage of physiological chemical conditions for release of the drugs. A compilation of the most important approaches is presented in the form of a table, where the main advantages and disadvantages of each strategy are also referred.

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Section: Prodrugs That Rely (Mostly) On Enzymatic Activationmentioning

confidence: 99%