Kinetics of Epidermal Growth Factor in Saliva

Ino, Motoko; Ushiro, Koichi; Ino, Chiyonori; Yamashita, Toshio; Kumazawa, Tadami

doi:10.3109/00016489309126195

Cited by 59 publications

(47 citation statements)

References 17 publications

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“…Removal of the submandibular gland in animals led to ulceration of the intestinal mucosa and slower wound healing (6). Subsequent topical application of EGF restored normal wound healing (7).…”

Section: Discussionmentioning

confidence: 98%

Basic Fibroblast Growth Factor (bFGF) in Saliva - Physiological and Clinical Implications

Ishizaki

Westermark²,

Setten³

et al. 2000

Acta Oto-Laryngologica

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Ishizaki H, Westermark A, van Setten G, Pyykkö I. Basic fibroblast growth factor (bFGF) in sali6a-physiological and clinical implications. Acta Otolaryngol 2000; Suppl 543: 193 -195. Basic fibroblast growth factor (bFGF) has significant properties in wound healing, tissue regeneration and ulcer repair of the upper digestive tract. The purpose of the present study was to identify and analyse factors affecting the concentration of bFGF in saliva from healthy human individuals. A commercially available enzyme-linked immunosolvent assay kit (ELISA) was used for the analyses of bFGF in saliva. In total, 56 samples were collected from 28 healthy subjects, 15 male and 13 female. Determination of bFGF was performed by spectrophotometer (wavelength 490 nm). bFGF was detected in all samples. Mean bFGF concentration was 0.87 pg/ml (SD 0.49) and the concentration ranged from 0.3 to 1.9 pg/ml. In subjects aged 22 to 49 years, no age-dependent variation in bFGF was present, females did not differ from males, and no difference was evident between European and Asian subjects. Smokers had significantly higher saliva concentrations of bFGF than non-smokers. Since bFGF, together with other growth factors, is involved in wound healing and tissue repair, we suggest that bFGF in saliva is involved in the reparative processes of mucous membranes.

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Section: Discussionmentioning

confidence: 98%

Basic Fibroblast Growth Factor (bFGF) in Saliva - Physiological and Clinical Implications

Ishizaki

Westermark²,

Setten³

et al. 2000

Acta Oto-Laryngologica

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“…Salivary EGF is present in patients with oral inflammation and in patients with head and neck carcinoma. 2,7 The effect of exogenous, continuous topically applied EGF on an experimental model of chemotherapy-induced oral mucositis has been assessed in a hamster model in which ulcerative mucositis was induced by 5-fluorouricil and subsequent mucosal irritation. 8 The effect of EGF was noted to be dependent on the timing of administration.…”

confidence: 99%

The correlation between epidermal growth factor levels in saliva and the severity of oral mucositis during oropharyngeal radiation therapy

Epstein

Gorsky

Guglietta³

et al. 2000

Cancer

116

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“…Epidermal growth factor might be synthesized by serous acinar cells, released into the primary saliva, and then delivered by transcytosis across striated duct cells to the interstitium and ultimately into the circulation [31].…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural study of the adult albino rat parotid gland with special reference to the role of stromal telocytes

El-Bassouny¹

2012

The Egyptian Journal of Histology

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Kinetics of Epidermal Growth Factor in Saliva

Cited by 59 publications

References 17 publications

Basic Fibroblast Growth Factor (bFGF) in Saliva - Physiological and Clinical Implications

Basic Fibroblast Growth Factor (bFGF) in Saliva - Physiological and Clinical Implications

The correlation between epidermal growth factor levels in saliva and the severity of oral mucositis during oropharyngeal radiation therapy

Ultrastructural study of the adult albino rat parotid gland with special reference to the role of stromal telocytes

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