Kinetics of electrically and chemically induced swelling in polyelectrolyte gels

Grimshaw, P.E.; Nussbaum, Jeremy H.; Grodzinsky, Alan J.; Yarmush, Martin L.

doi:10.1063/1.458729

Cited by 206 publications

(135 citation statements)

References 22 publications

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…Modeling of electrical charges on the constituents of a mixture makes it possible to analyze phenomenasuch as Donnan potential and osmotic pressure, streaming and diffusion potentials and electro-osmosis (Overbeek, 1956;Grimshaw et al, 1989Grimshaw et al, , 1990Gu et al, 1993Gu et al, , 1997Gu et al, , 1998. These phenomena may be relevant to processes at the tissue level as well as at the cellular level.…”

Section: Governing Equations For Reactive Mixturesmentioning

confidence: 99%

On the theory of reactive mixtures for modeling biological growth

Ateshian

2007

Biomech Model Mechanobiol

183

View full text Add to dashboard Cite

Mixture theory, which can combine continuum theories for the motion and deformation of solids and fluids with general principles of chemistry, is well suited for modeling the complex responses of biological tissues, including tissue growth and remodeling, tissue engineering, mechanobiology of cells and a variety of other active processes. A comprehensive presentation of the equations of reactive mixtures of charged solid and fluid constituents is lacking in the biomechanics literature. This study provides the conservation laws and entropy inequality, as well as interface jump conditions, for reactive mixtures consisting of a constrained solid mixture and multiple fluid constituents. The constituents are intrinsically incompressible and may carry an electrical charge. The interface jump condition on the mass flux of individual constituents is shown to define a surface growth equation, which predicts deposition or removal of material points from the solid matrix, complementing the description of volume growth described by the conservation of mass. A formu-lation is proposed for the reference configuration of a body whose material point set varies with time. State variables are defined which can account for solid matrix volume growth and remodeling. Constitutive constraints are provided on the stresses and momentum supplies of the various constituents, as well as the interface jump conditions for the electrochem cal potential of the fluids. Simplifications appropriate for biological tissues are also proposed, which help reduce the governing equations into a more practical format. It is shown that explicit mechanisms of growth-induced residual stresses can be predicted in this framework.

show abstract

Section: Governing Equations For Reactive Mixturesmentioning

confidence: 99%

On the theory of reactive mixtures for modeling biological growth

Ateshian

2007

Biomech Model Mechanobiol

183

View full text Add to dashboard Cite

show abstract

“…Although some cases have been described in literature of effective immobilisation of different ions in hydrogels [23], in the present systems the immobilization of surfactant seems a rather complex concept. At the same time the gel swelling and shrinking processes are not pure diffusion processes.…”

Section: Kinetic Studiesmentioning

confidence: 99%

Diffusion coefficients of sodium dodecyl sulfate in water swollen cross-linked polyacrylamide membranes

Valente

Miguel

Lobo

2002

European Polymer Journal

View full text Add to dashboard Cite

Diffusion of aqueous sodium dodecyl sulfate (SDS) across cross-linked polyacrylamide hydrogel membranes has been studied by electrical conductivity measurements. Initial rapid sorption of SDS (as unimer) into the membranes is observed. The effect of SDS concentration, and of cross-linker fraction on the degree of swelling of the gels is studied and associated with binding of the surfactant to the polymer, with surface bound water suggested to be involved in these interactions. Below the surfactant critical micelle concentration, volume collapse of less cross-linked membranes is observed, and associated with aggregate formation. Fluorescence measurements using pyrene as a probe show that micellar aggregates do not diffuse through the membrane, and only overall unimer diffusion is observed. The effect of cross-linking on the diffusion process is discussed.

show abstract

“…The Donnan exclusion effect seen in swelling kinetics does not play a role in deswelling (28). Since the deswelling process consists of the formation of a neutral outer layer, protons are not required to overcome a Donnan potential.…”

mentioning

confidence: 97%

Buffer effects on aqueous swelling kinetics of polyelectrolyte gels

Chou

Blanch

Prausnitz

et al. 1992

J of Applied Polymer Sci

View full text Add to dashboard Cite

Electrolytes are often added to a gel‐swelling medium under the assumption that the important conditions which characterize swelling rates are the solution pH and ionic strength, with little emphasis on the nature of the electrolyte. Previous research by Siegel et al. has indicated that the presence of the un‐ionized acidic form of an electrolyte buffer is a primary rate determinant for swelling of a polybase gel. A systematic swelling study on two separate gels, 2‐hydroxyethyl methacrylate copolymerized with methacrylic acid (HEMA/MAA) and N,N‐dimethylaminoethyl methacrylate (HEMA/DMA), has been performed to investigate the influence of the concentration of the un‐ionized buffer by three principal factors: (1) total buffer concentration, (2) solution pH, and (3) buffer pKa. Swelling and deswelling kinetics were obtained. In the presence of an electrolyte buffer, a dramatic swelling rate increase is observed for the HEMA gels, with substantial gains in rate obtained as total buffer concentration rises. Results also emphasize that to enhance swelling kinetics, the pH must be such that the buffer is essentially un‐ionized.

show abstract

Kinetics of electrically and chemically induced swelling in polyelectrolyte gels

Cited by 206 publications

References 22 publications

On the theory of reactive mixtures for modeling biological growth

On the theory of reactive mixtures for modeling biological growth

Diffusion coefficients of sodium dodecyl sulfate in water swollen cross-linked polyacrylamide membranes

Buffer effects on aqueous swelling kinetics of polyelectrolyte gels

Contact Info

Product

Resources

About