Kinetics of Desflurane, Isoflurane, and Halothane in Humans

Brief review: Theory and practice of minimal fresh gas flow anesthesia

“…The equilibrium between gas and blood is well-recognized from the classical wash-in and wash-out curves describing Faa/Fiaa. 40 Thus, the increase in endtidal anesthetic gas is reduced when inhaled agents with lower blood to gas solubility are used (Fig. 1).…”

The uptake of enflurane during anaesthesia

“…Whilst depression of cardiac output by enflurane may well reduce the proportion perfusing muscle, luxury perfusion of fat would be extraordinary. It is possible that edurane is indeed being absorbed by fat by diffusion from vessel rich tissue [5,21].…”

“…During anaesthesia, the rate of volatile anaesthetic uptake normally declines smoothly [l, 21. Interest in uptake is not entirely academic; since metabolism of this inhalational agent is quoted as a proportion of the administered dose, knowledge of the uptake of enflurane, which is 2.3%-10.8% metabolised [3-51, enables estimation of the metabolic load [6,7].…”

Central Hemodynamic Features in Elderly Patients During General Anesthesia with Sevoflurane

“…Первые клинические испытания препарата, про веденные в 1990 г. в Японии, полностью оправдали воз ложенные на него ожидания, а дальнейшее клиническое применение позволило считать этот препарат очеред ным значимым этапом на пути достижения цели созда ния «идеального анестетика» [11][12][13].…”