“…Also, the inflamed tissue presents pro-inflammatory cytokines (IFN-γ, TNF-α) and chemokines (RANTES, MIP-1α, JE/MCP-1). These might selectively and preferentially recruit CD8 + T cells leading to the establishment of CD8-mediated myocarditis (Talvani et al 2000, dos Santos et al 2001. Novel therapeutic strategies aiming at limiting the inflammatory damage of cardiomyocytes, targeting integrin-mediated adhesion and chemokine-driven recruitment of leukocytes, besides the specific anti-T. cruzi drugs, should be evaluated.…”