Kinetics of Chemical Processes in the Human Brain. Trigger Effect and Self-Stabilization of N-Acetylaspartic Acid

Dynamics of the Multipathway Regulation of the Vasodilator Bold Effect Induced by a Nerve Impulse: A Kinetic Model of the Neurovascular Coupling Process

“…What agents are key mediators of neurovascular coupling? In accordance with the previous works, − the biochemical model of neurovasodilator coupling includes several key metabolites that participate in neuronal and vasodilator processes. The regulation process has a multipathway character with the participation of Ca 2+ ions and several enzymatic systems (Scheme ).…”

“…To construct a biochemical sequential-parallel scheme, the data from ref were used. A kinetic model of the changes in oxygen concentration was built on base the results from previous studies − ,, and served as the experimental data for the analysis of the dynamic changes in the BOLD signal. The ordinary differential equation (ODE) system was integrated using a specially developed program (in the Delphi Community Edition).…”

“…26 The biochemical aspects of neurovasodilator coupling have been described in sufficient detail elsewhere. [18][19][20]25,27 The aims of this work are A-the translation of the biochemical scheme of the process into formal kinetic language, construction of a kinetic model and description of experimental data (visual 28 and sensorimotor activation 29 ). B-a study of the main roles of participants in neurovasodilator coupling with variations in the kinetic parameters of the process.…”

“…The elucidation of the molecular-dynamic nature of neurovascular coupling is of fundamental importance. A rather effective and fruitful approach is the kinetic modeling of the process, which allows the dynamics of the process and effects over time to be described on the basis of available experimental data. − We were able to describe the observed dynamics of the BOLD signal and a number of subsequent metabolic processes on the basis of the chemical kinetic approach …”

“…In addition, Ca 2+ ions are activators of phospholipase A 2 , which is a producer of polyunsaturated fatty acids (arachidonic acid), an activator of NO synthase, an enzyme, and a NO producer . The biochemical aspects of neurovasodilator coupling have been described in sufficient detail elsewhere. − ,, …”