Kinetics of Calcium and Phosphate Release from the Surface of Implants Coated Using Different Techniques

Кононович, Н. А.; Stogov, M. V.; Попков, А. В.; Горбач, Е. Н.; Kireeva, E. A.; Тушина, Н. В.; Попков, Д. А.

doi:10.1007/s10527-019-09906-z

Cited by 4 publications

(2 citation statements)

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“…Coating techniques are diverse and have been much improved to provide HA retention on the metal implant [10,15,16]. It was also shown that the kinetics of the release of calcium and phosphate from the surface of rods coated with calcium phosphate depends on the method of coating [17].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Nanostructured Hydroxyapatite Coating on Distraction Osteogenesis

Кононович

Попков

Горбач

et al. 2020

KEM

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Dogs underwent high-frequency automated tibia lengthening with the Ilizarov apparatus over a 1.8-mm hydroxyapatite-coated intramedullary titanium wire. Daily distraction was 3.0 mm with a fraction of 0.125 mm/h and continued ten days. The regenerate was well vascularized, had zonal structure and was of normal or hyperplastic type to the end of distraction. Osteogenesis was fast and complete. The wire served for both mechanical and biological reinforcement of the bone callus and provided reduction of external fixation time. Mean consolidation time with the apparatus on the limb was 13.83±4.02 days. Overall, external fixation index was 10.5 days/cm and 4.8 days/cm in the consolidation phase.

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Section: Discussionmentioning

confidence: 99%

The Effect of Nanostructured Hydroxyapatite Coating on Distraction Osteogenesis

Кононович

Попков

Горбач

et al. 2020

KEM

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“…Существуют разные способы нанесения таких покрытий на металлическую основу [35,36]. В выполненном исследовании биоактивный кальций-фосфатный слой был сформирован на пористой поверхности методом микродугового оксидирования, преимущества и эффективность использования которого были доказаны и представлены в предыдущих публикациях и в других литературных источниках [37,38,39].…”

Section: обсуждение основного результата исследованияunclassified

Efficiency of 3D Implants with Bioactive Properties for Treatment of Extensive Bone Defects: Experimental Study

Попков

Кононович

Горбач

et al. 2021

Traumatology and Orthopedics of Russia

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Background. The problem of replacing extensive bone defects remains relevant. The use of implant structures with bioactive properties can stimulate osteogenesis, which will improve the final treatment result.The aim of the study. In an in vivo experiment, to study the possibility of replacing an extensive defect in the bone diaphysis with a personal bioactive cellular 3D implant and evaluate the long-term results of its use.Materials and Methods. In an in vivo experiment, adult large mongrel dogs (n = 8) were modeled with an extensive segmental defect of the tibial diaphysis measuring 4 cm. The defect was replaced with a cellular bioactive 3D implant made of titanium alloy Ti6Al4V, manufactured using the additive technology. The diameter of the cells was 1.5 mm on average. The walls of the implant had pores of 100– 300 μm in size. The inner and outer surfaces were coated with a calcium phosphate layer formed by micro-arc oxidation. The primary fixation was provided with the Ilizarov apparatus. In the early postoperative period, antibiotic prophylaxis with broad-spectrum drugs was performed. Clinical, X-ray, histological and statistical methods were used to analyze the results. The main control points were considered: the end of external fixation with the Ilizarov apparatus, after 180 days and 1 year after the termination of external fixation.Results. During the experiment, the death of animals and complications were not observed. The spatial location of the implant was preserved. The formation of a strong bone-implantation block occurred 37.2±6.3 days after the operation. During this period, the external fixation apparatus was dismantled. Osseointegration was provided under conditions of sufficient primary mechanical stability, due to the cellular structure of the implant, the presence of pores on its walls, and the osteoinductive properties of the applied calcium phosphate coating. The achieved degree of osseointegration persisted in long-term periods (6 months and 1 year after the termination of external fixation). The osteoinductive properties of the calcium phosphate coating were confirmed by the expression of osteopontin cells at all stages of the experiment. Outflow of Ca and P from bone fragments was not observed. An elastic sheath was formed on the surface of the implant, similar in structure to the periosteum. The implant cells were filled with a well-vascularized bone substrate. In the projection of the intermediate zone, compact bone tissue was formed, and in the projection of the medullary canal — reticulofibrous bone marrow. This indicates the possibility of organotypic remodeling of bone structures inside the implant.Conclusion. The results of the study showed the effectiveness of using a bioactive cellular 3D implant to replace an extensive defect in the shaft of the bone. The architectonics and osteoinductive properties of the implant surface contributed to the formation of complete osseointegration in a short time, while maintaining the achieved result in long-term periods.

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