Kinetics aspects of Gamma-hydroxybutyrate dehydrogenase

Taxon, Esther; Halbers, Lila P.; Parsons, Stanley M.

doi:10.1016/j.bbapap.2020.140376

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…the native Cupravidus nudix hydrolase and Escherichia coli nudix hydrolase (nudF) as a fusion protein. In both cases, the forward reaction (alcohol→aldehyde) was activated by the respective enzymes successfully, whereas the reverse reaction doesn't comprise their participation 33 …”

Section: Physiological Rolementioning

confidence: 99%

“…In both cases, the forward reaction (alcohol→aldehyde) was activated by the respective enzymes successfully, whereas the reverse reaction doesn't comprise their participation. 33 Remarkably, some Mdh have evolved to be ACT independent, for example, C. necator N-1 Mdh2 shows comparative methanol dehydrogenase activity to B. methanolicus Mdh with ACT. 34 However, the mutation S97G overrules the effect of ACT on Mdh of B. methanolicus resulting in complete insensitivity toward the protein.…”

Section: Methanol Metabolismmentioning

confidence: 99%

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Industrial light at the end of the iron‐containing (group III) alcohol dehydrogenase tunnel

Shanbhag

Ghatak

Rajagopal

2022

Biotech and App Biochem

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There are three prominent alcohol dehydrogenases superfamilies: short‐chain, medium‐chain, and iron‐containing alcohol dehydrogenases (FeADHs). Many members are valuable catalysts for producing industrially relevant products such as active pharmaceutical intermediates, chiral synthons, biopolymers, biofuels, and secondary metabolites. However, FeADHs are the least explored enzymes among the superfamilies for commercial tenacities. They portray a conserved structure having a “tunnel‐like” cofactor and substrate binding site with particular functions, despite representing high sequence diversity. Interestingly, phylogenetic analysis demarcates enzymes catalyzing distinct native substrates where closely related clades convert similar molecules. Further, homologs from various mesophilic and thermophilic microbes have been explored for designing a solvent and temperature‐resistant enzyme for industrial purposes. The review explores different iron‐containing alcohol dehydrogenases potential engineering of the enzymes and substrates helpful in manufacturing commercial products.

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Section: Physiological Rolementioning

confidence: 99%

Section: Methanol Metabolismmentioning

confidence: 99%

Industrial light at the end of the iron‐containing (group III) alcohol dehydrogenase tunnel

Shanbhag

Ghatak

Rajagopal

2022

Biotech and App Biochem

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The EFFECT OF SALT STRESS ON THE CATALYTIC ACTIVITY OF Γ-Hydroxybutyrate DEHYDROGENASE IN THE LEAVES OF MAIZE ZEA MAYS L.

Plotnikova,

Anohina,

Eprintsev

2024

Materials of the International Youth Scientific and Practical Conference "FORESTRY-BIOLOGICAL FOUNDATIONS OF SUSTAINABILITY OF

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Soil salinity is one of the main problems in agriculture, and it has a significant impact on the growth and development of agricultural crops. High salt content in the soil leads to increased osmotic pressure, which hinders the uptake of water and nutrients by the plant. This leads to changes in plant metabolism, in particular, disrupting the functioning of the Krebs cycle, which is the main source of energy for plant growth. In addition, soil salinity affects the functioning of the GABA-shunt, which plays an important role in regulating stress responses in plants. The enzyme γ-hydroxybutyratedehydrogenase (GBDH) plays an important role in the adaptation of plants to abiotic stresses. Unfortunately, the functioning of this enzyme in plant cells is still poorly understood. Therefore, we studied the effect of salt stress on the enzymatic activity of GBDH in the leaves of corn seedlings. It was shown that salt stress induces GBDH activity in the leaves of corn starting from the first hour of incubation in the stressful environment.

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Kinetics aspects of Gamma-hydroxybutyrate dehydrogenase

Cited by 2 publications

References 37 publications

Industrial light at the end of the iron‐containing (group III) alcohol dehydrogenase tunnel

Industrial light at the end of the iron‐containing (group III) alcohol dehydrogenase tunnel

The EFFECT OF SALT STRESS ON THE CATALYTIC ACTIVITY OF Γ-Hydroxybutyrate DEHYDROGENASE IN THE LEAVES OF MAIZE ZEA MAYS L.

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