Kinetics and Thermodynamics of Drug Permeation Through Silicone Elastomers iv. Effect of Polymer Backbone Structure

Lee, Chi-Long; Ulman, Katherine L.; Larson, Kent R.

doi:10.3109/03639048609026619

Cited by 13 publications

(2 citation statements)

References 18 publications

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“…In our previous work,2 the objective was to select silicon rubber base materials that will allow the development of a new TTS with optimal characteristics. Several publications have dealt with the characteristics of silicon membranes or with the testing of material diffusion through membranes9–17; however, commercially available silicon rubber films or factory kits used for manufacturing silicon rubber were used in these studies and, unfortunately, it is very difficult to establish what additives they really contain. Since the additives used change fundamentally the characteristics of the base materials, therefore, general conclusions from these results can only be drawn with difficulty and with reservations.…”

Section: Resultsmentioning

confidence: 99%

Development of a new silicone‐base transdermal therapeutic system. II. Study of trifunctional ingredients

Wagner

2001

J of Applied Polymer Sci

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ABSTRACT:The effect of two trifunctional silicon compounds was investigated on the polarity behavior of silicone elastomers by investigating the swelling properties in solvents of various polarity. The properties of the silicone elastomer were also influenced by methyltrimethoxysilane (MTS) and N-[(aminoethyl)aminopropyl]trimethoxysilane (GF-91) if they were used together with the networking agent. The cooperative effect of the polar liquid ingredients [glycerol, ethylene glycol, propylene glycol, poly(ethylene glycol) 400] and GF-91 as well as the dissolution of the liquid ingredients from the silicone elastomer were studied.

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Section: Resultsmentioning

confidence: 99%

Development of a new silicone‐base transdermal therapeutic system. II. Study of trifunctional ingredients

Wagner

2001

J of Applied Polymer Sci

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“…Silicone rubber has been already used as a coating material for cochlear implant electrodes, and the authors have already reported a novel approach in drug delivery to cochlea by incorporation of DEX as a biologically active ingredient into the silicone rubber coating of the electrode array 18. The extent of curing and consequently, degree of crosslinking in these elastomers can strongly influence their physical properties26 including their permeability to incorporated drugs via diffusion of entities which in turn implies that release profile of drugs from devices made of silicone rubber is strongly dependent on its crosslinked structure 27, 28. Curing kinetics of silicone elastomers is investigated by different analytical techniques such as differential scanning calorimetry (DSC)29 or equilibrium swelling studies in good solvents 30.…”

Section: Introductionmentioning

confidence: 99%

Curing behavior of silicone elastomer in the presence of two corticosteroid drugs

et al. 2012

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Silicone rubbers are widely used as carriers for delivery of drugs intended for parenteral administration as implantable devices. Drugs having different functional groups can significantly affect curing profile of silicone rubber, which in turn may negatively affect their biological applicability due to the loss in mechanical and drug retaining properties. To this end, the effects of two corticosteroid analogs (up to 2 %w/w of drug loading) that is, dexamethasone (DEX) and its sodium phosphate ester (DSP) on curing behavior of a non-restricted, two part RTV silicone rubber was studied using different characterization techniques including spectroscopic (FTIR), calorimetric (DSC), oscillating disk rheometry, and swelling studies. The results showed that curing time extends longer for DSP-loaded samples compared to the non-loaded silicone rubber. The presence of DSP in the formulation interferes in the curing of silicone elastomers, probably due to the thermal decomposition of DSP according to the spectral changes observed in FTIR spectra as confirmed by DSC analysis. Rheometric studies showed depreciated properties for silicone elastomers upon compounding with DSP. Swelling measurements indicated to lowered crosslink density for networks and increasing M(c) upon adding DSP to the formulations which can be attributed to disruption in crosslinking reaction by sodium phosphate moieties of DSP.

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Silicone elastomers: study of their mesh size by thermal analysis

Moreau

Madelmont

Leclerc

et al. 1995

J Mater Sci: Mater Med

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Silicone elastomers are often used as a base for controlled-release systems material for drugs. The modulation of drug diffusion by varying the mesh size of a silicone elastomer network has already been studied. In this work we have investigated the influence of vulcanization conditions and chemical modifications on the network mesh size by thermal analysis and measurement of the swelling ratio. In parallel, the influence of these same parameters on the diffusion of model drugs has been studied.

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Kinetics and Thermodynamics of Drug Permeation Through Silicone Elastomers iv. Effect of Polymer Backbone Structure

Cited by 13 publications

References 18 publications

Development of a new silicone‐base transdermal therapeutic system. II. Study of trifunctional ingredients

Development of a new silicone‐base transdermal therapeutic system. II. Study of trifunctional ingredients

Curing behavior of silicone elastomer in the presence of two corticosteroid drugs

Silicone elastomers: study of their mesh size by thermal analysis

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