Kinetics and mechanistic study of polynuclear platinum(II) polypyridyl complexes; A paradigm shift in search of new anticancer agents

Non-conventional synthesis and photophysical studies of platinum(ii) complexes with methylene bridged 2,2′-dipyridylamine derivatives

“…Metal center was chosen to be platinum(II), which is often used in development of phosphorescent materials due to its strong spin-orbit coupling; 36 complexes of platinum(II) with dpa-based ligands are also considered as potential anticancer agents. [12][13][14][15] In addition, synthesis of [Pt(dpa-H) 2 ] 33 and methylation of a structurally related bis(imidoylamidinate)platinum(II) complex [Pt{NHvC(Ph)-NC(Ph)vNPh} 2 ], 37 which can be seen as prototype for the dpa benzylation reaction, have been published previously (Scheme 3).…”

“…42 In addition, previously published computational studies on platinum(II) complexes with dpa derived ligands revealed a significant contribution of the metal center in the frontier molecular orbitals. 15 Therefore, the low energy absorptions in [7][8][9][10]•Br 2 are assigned to π-π* transitions within dpa moiety with an additional metal-to ligand charge transfer contribution. ‡ Solutions of [7-10]•Br 2 are not luminescent in methanol at room temperature.…”

“…7,8 Since dpa complexes of platinum(II) and palladium(II) have been found to possess cytotoxic activities comparable to or higher than cisplatin, [9][10][11] complexes with dpa derivatives have been considered as potential antitumor agents. [12][13][14][15] Variety of conjugated derivatives and their metal complexes, in which the amino nitrogen atom of dpa is directly connected with an aromatic system, have been synthesized and studied by the group of S. Wang 6,[16][17][18] and more recently by K.-J. Wei et al [19][20][21] Despite their attractive luminescent properties, real life application of such materials can be hindered by the complicated synthesis, which often involves transition metal catalyzed cross-coupling reactions (Scheme 1, left).…”

A New Pt(II) Complex with Anionic s-Triazine Based NNO-Donor Ligand: Synthesis, X-ray Structure, Hirshfeld Analysis and DFT Studies

“…This tailored architecture was designed by the Han research group [ 5 ]. This fascinating s -triazine ligand has attracted great attention due to its several applications [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Mao et al designed and synthesized two trigeminal star-like platinum complexes which stabilized hTel G4 with high selectivity and affinity, targeting telomerase inhibitors [ 14 ].…”