Abstract:The kinetics of oxidation of gabapentin (Neurontin) (GP) by diperiodatonickelate(IV) (DPN) in aqueous alkaline medium was studied spectrophotometrically. The reaction is first order with respect to [DPN] and is an apparent less than unit order, each in [GP] and [alkali] under the experimental conditions. Reaction rate increases with increase in ionic strength and in solvent polarity of the medium. Addition of reaction products has no effect on the reaction rate. A mechanism involving the formation of a complex… Show more
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