Kinetics and Mechanism of Drug Release From Calcium Alginate Membrane Coated Tablets

Bhagat, Hitesh R.; Mendes, Robert W.; Mathiowitz, Edith; Bhargava, Hridaya N.

doi:10.3109/03639049409050191

Cited by 20 publications

(4 citation statements)

References 5 publications

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“…The calcium-induced gelation of alginate is irreversible unless treated with strong chelating agents at an alkaline pH (Klock et al, 1994). Ca ++ alginate has been used in the preparation of fabricated foods (Nussinovitch and Peleg, 1990), for immobilization of cells (Lacroix et al, 1990), controlled delivery of bioactive materials (Bhagat et al, 1994), and cryopreservation of plantlets in micropropagation (Plessis et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Calcium Alginate Films: Thermal Properties and Permeability to Sorbate and Ascorbate

Wong

Gregorski

Hudson

et al. 1996

Journal of Food Science

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Calcium alginate films were prepared by the pH-controlled release of calcium ions into alginate solution or by the cooling of hot calcium alginate gels. Thermogravimetry and calorimetry showed that the controlled Ca release films contained a greater amount of high-temperature component, and required extra energy to dissociate the tightly crosslinked calcium alginate. Structural differences were reflected by the permeability of the two films to potassium sorbate: 1.06 ϫ 10 Ϫ7 (controlled Ca release) and 1.58 ϫ 10 Ϫ7 cm 2 ⅐sec Ϫ1 (cooled). Apparent activation energy was estimated to be for the diffusion of potassium sorbate 24.1 KJ⅐mol Ϫ1 , sodium ascorbate 23.7, and ascorbic acid 36.2. Results suggested that the pH of the diffusant solution had an interactive effect on the alginate film.

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Section: Introductionmentioning

confidence: 99%

Calcium Alginate Films: Thermal Properties and Permeability to Sorbate and Ascorbate

Wong

Gregorski

Hudson

et al. 1996

Journal of Food Science

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“…The dried alginate beads have the property of reswelling and thus can act as controlled release system [9][10][11][12]. They are nontoxic orally and have a protective effect on the mucous membranes of the upper gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Sustained Release of Verapamil Hydrochloride from Sodium Alginate Microcapsules

Farhana

Shantakumar

Shyale³

et al. 2010

CDD

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The objective of the present study was to develop sustained release microcapsules of verapamil hydrochloride (VH) using biodegradable polymers. For this purpose microcapsules embedded verapamil hydrochloride were prepared using sodium alginate alone and also by incorporating some co polymers like methyl cellulose(MC), sodium carboxy methyl cellulose (SCMC), poly vinyl pyrrollidone (PVP) and xanthan gum by employing complex emulsion method of microencapsulation. Microcapsules were prepared in various core: coat ratios to know the effect of polymer and co polymers on drug release. Overall ten formulations were prepared and evaluated for flow behavior, sieve analysis, drug entrapment efficiency, in vitro dissolution studies, stability studies, including scanning electron microscopy and DSC. The resulting microcapsules were discrete, large, spherical and also free flowing. The drug content in all the batches of microcapsules was found to be uniform. The release was dependeut on core: coat ratio and nature of the polymers. FTIR analysis revealed chemical integrity between Verapamil hydrochloride (VH), sodium alginate and between the copolymers. Among the four copolymers used methyl cellulose retarded the drug release more than the other three, hence the same formulation was subjected for in vivo studies. The drug release from the microcapsules was found to be following non fickian diffusion. Mechanism of drug release was diffusion controlled first order kinetics. Drug diffusion co efficient and correlation co-efficient were also assessed by using various mathematical models. In vivo result analysis of pharmacokinetic parameters revealed that t max of reference and test formulations were almost same. From the study it was concluded that, sustained release Verapamil hydro chloride microcapsules could be achieved with success using sodium alginate alone and also in combination with other biodegradable polymers.

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“…Since it is guluronic acid that preferentially binds with calcium ions, with increase in the guluronic acid content (and therefore, decrease in mannuronic acid content), calcium alginate polymer may have higher cross-linking and also, improved acid stability [6].…”

Section: Introductionmentioning

confidence: 99%

Investigation of factors influencing drug release using calcium alginate polymer

Al-Zahrani

1999

Bioprocess Engineering

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The effects of mixing, the sodium alginate concentration, and calcium chloride concentration on the release of sulphamethoxazole (model drug) impregnated in calcium alginate beads were investigated and evaluated. The release behaviour of the sulphamethoxazole from the calcium alginate beads was studied in a 0.1N HCl aqueous solution at 37°C. The release rate of the sulphamethoxazole depends heavily on the type of mixers during the formation of the drug-alginate beads. The highest release rate was achieved when four-bladed rectangular agitator was used while the lowest release was achieved when magnetic stirrer was used. The amount of the released sulphamethoxazole varies slightly with the variation of the alginate concentration. The total release of sulphamethoxazole when 1% w/v solution of sodium alginate was used found to be 80% of the total drug content while 72% and 68% of the total drug content for 1.5% and 2% sodium alginate solutions. Three different calcium chloride concentrations were used (i.e., 5%, 10%, and 15% CaCl 2 ). The effect of the calcium chloride concentration on the release of the sulphamethoxazole is very pronounced.

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Kinetics and Mechanism of Drug Release From Calcium Alginate Membrane Coated Tablets

Cited by 20 publications

References 5 publications

Calcium Alginate Films: Thermal Properties and Permeability to Sorbate and Ascorbate

Calcium Alginate Films: Thermal Properties and Permeability to Sorbate and Ascorbate

Sustained Release of Verapamil Hydrochloride from Sodium Alginate Microcapsules

Investigation of factors influencing drug release using calcium alginate polymer

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