Kinetics and docking studies on the effect of chemical modification of NADH for redox reactions with dehydrogenases

Ma, Hui; Zhang, Songping; Su, Zhiguo; Wang, Ping

doi:10.1016/j.molcatb.2012.01.018

Cited by 5 publications

(1 citation statement)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…97 The initial uptake coefficients on fresh films were found to be inversely dependent on the ozone concentration, varying from 10 -6 for ozone concentrations of 10 14 molecules/cm 3 to 10 -5 at 10 13 molecules/cm 3 . These coefficients were not dependent on the relative humidity, up to 75%, within the precision of the experiment.…”

Section: Ozone Decompositionmentioning

confidence: 93%

Chemical Kinetics and Reaction Mechanisms in Solvent Extraction: New Trends and Applications

El-Hefny¹

2017

JPS

View full text Add to dashboard Cite

show abstract

Section: Ozone Decompositionmentioning

confidence: 93%

Chemical Kinetics and Reaction Mechanisms in Solvent Extraction: New Trends and Applications

El-Hefny¹

2017

JPS

View full text Add to dashboard Cite

show abstract

Biocatalysis

Torrelo

Hanefeld

Hollmann

2015

Kirk-Othmer Encyclopedia of Chemical Technology

View full text Add to dashboard Cite

Biocatalysis, the use of enzymes—either as isolated enzymes or in whole cells—to accelerate chemical transformations, is one of the approaches available to the organic chemist. Key advantages of biocatalysis are its high selectivity and the high rate of chemical transformations at relatively mild reaction conditions, and as a result, the simplified downstream processing and more cost‐effective synthesis. Therefore, it is not surprising that interest in industrial biocatalysis has been on the rise. The aim of this chapter is to provide the process chemist with a general overview of the available enzymes and the chemistries they enable and to discuss concepts in biocatalysis highlighted by selected examples.

show abstract

1,2-Diazole and 2,2,2-Trifluoroethanol and Their Regulatory Effects on Ethanol and Lactic Acid Formation in the Living Culture of Rhizopus oryzae

Thitiprasert

Sooksai

Thongchul

2013

Appl Biochem Biotechnol

View full text Add to dashboard Cite

In heterofermentation of Rhizopus oryzae, ethanol is the major byproduct which reduces the production of a desired product, an optically pure L-lactic acid. To improve lactic acid production, regulating the alcohol fermentative pathway to limit ethanol production has been done by various techniques. In vitro study on alcohol dehydrogenase (ADH) inhibition in several organisms showed that 1,2-diazole and 2,2,2-trifluoroethanol were competitively bound at the active sites that eventually limited ethanol production. In this study, 1,2-diazole and 2,2,2-trifluoroethanol were present during fermentation of R. oryzae. It was found that both 1,2-diazole and 2,2,2-trifluoroethanol not only strongly affected ethanol formation but they also indirectly regulated lactate production as observed by the decreasing affinity for glucose flux toward lactate and ethanol production. The increase in both ethanol and lactate formation rates revealed 1,2-diazole and 2,2,2-trifluoroethanol not only regulated the reversible redox reaction by ADH, but they also caused the dynamic change in the conversion of all metabolites in the living R. oryzae in order to maintain the balanced flux for cellular growth and maintenance.

show abstract

Kinetics and docking studies on the effect of chemical modification of NADH for redox reactions with dehydrogenases

Cited by 5 publications

References 45 publications

Chemical Kinetics and Reaction Mechanisms in Solvent Extraction: New Trends and Applications

Chemical Kinetics and Reaction Mechanisms in Solvent Extraction: New Trends and Applications

Biocatalysis

1,2-Diazole and 2,2,2-Trifluoroethanol and Their Regulatory Effects on Ethanol and Lactic Acid Formation in the Living Culture of Rhizopus oryzae

Contact Info

Product

Resources

About