Kinetic Study of Reactions of Aniline and Benzoyl Chloride Using NH₃ as Acid Absorbent in a Microstructured Chemical System

Abstract

NH 3 was used as acid absorbent to intensify the reactions between aniline and benzoyl chloride in a microstructured chemical system in this work. By suppressing the side reaction, the addition of NH 3 could reduce the reaction time needed for 99% reactants conversation to less than 1/10 of the condition without NH 3 . Furthermore, a complete kinetic model containing two rapid main reactions and two reversible consecutive side reactions was established, and six reaction rate constants and their corresponding activation energies and pre-exponential factors as well as confidence intervals were determined precisely. The accuracy of the obtained parameters was verified by comparing the calculated data with experimental data at extensional temperature. The kinetic model was used to optimize the intensification operating conditions, and effects of reactants concentration, temperature, NH 3 addition amount, and NH 3 feed methods were discussed based on the simulation results. This work proves that the microstructured chemical system not only provides an effective intensification ability but also develops a reliable platform for kinetic studies.

Measuring Interfacial Polymerization Kinetics Using Microfluidic Interferometry

“…Using this with K = 0.0024 ± 2 × 10 –4 (Figure S10), and an oil-phase MPD diffusivity D o = 1630 ± 90 μm 2 /s (Figure S11), in eq reveals a reaction rate constant k = 110 ± 35 L/mol·s. This compares well with the rate constant measured for the analogous reaction between aniline and benzoyl chloride (monofunctional versions of monomers used here) in N -methyl-2-pyrrolidone, for which k = 128–164 L/mol·s. , Given that N -methyl-2-pyrrolidone is a more polar solvent which stabilizes the charged transition state, the slightly smaller value reported here for k seems reasonable …”

“…This compares well with the rate constant measured for the analogous reaction between aniline and benzoyl chloride (monofunctional versions of monomers used here) in N-methyl-2-pyrrolidone, for which k = 128−164 L/ mol•s. 35,36 Given that N-methyl-2-pyrrolidone is a more polar solvent which stabilizes the charged transition state, the slightly smaller value reported here for k seems reasonable. 37 The previous discussion holds for the early stage in the reaction, where transport resistance due to a dense film is absent.…”

Kinetics Study of Sulfuric Acid Alkylation of Isobutane and Butene Using a Microstructured Chemical System

“…H 2 SO 4 and hydrocarbon feed were delivered into the membrane dispersion microreactor (with the average diameter of 5 μm) by metering pumps (Beijing Satellite Co., Ltd.), respectively. The details of the reactor have been presented in our previous work . The delay loop (an inner diameter of 2 mm and an external diameter of 3 mm) with different length was connected to the reactor.…”

“…Microstructured chemical systems show obvious advantages in kinetics measurement because of their good dispersion and the precise control of reaction time, as well as reaction conditions, especially for the rapid reaction of a heterogeneous system. − Plenty of kinetics studies were conducted in microstructured chemical systems, especially for a fast reaction controlled by mass transfer. − Zhang et al obtained the reaction kinetics of dehydrochlorination of dichloropropanol in a microstructured chemical system, showing distinct values for reaction mechanism understanding . Wang et al conducted experiments on the kinetics study of an aniline and benzoyl chloride reaction in a microstructured chemical system .…”

Effect of Pyridine and Tribenzylamine on the Hydrolysis Kinetics of Benzoyl Chloride in Water-Dioxane System

“…A kinetic study of reactions of aniline and benzoyl chloride using ammonia as acid absorbent in a micro structured chemical system was conducted by Wang et al [3]. They found that the reaction time is reduced by 99 % when ammonia was used compared to condition without ammonia.…”