Kinetic study of humic acid adsorption onto smectite: The role of individual and blend background electrolyte

145

Three new Cu (II), Pd (II) and Ag (I) complexes of bidentate Schiff base ligand 2-[(4-chlorobenzylidene)amino] phenol (HL) were synthesized. The stoichiometric ratios and physicochemical properties of these complexes were determined using elemental analyses, magnetic measurements, infrared and UVvisible spectra, molar conductivity measurements and thermal analyses. The results revealed that the metal ions coordinated with through azomethine nitrogen and phenolic oxygen atoms. AgL and PdL complexes are present in a 1:1 molar ratio with square planar and tetrahedral geometry, respectively, while CuL 2 complex is present in a 1:2 molar ratio with octahedral geometry. The electronic structure and nonlinear optical parameters of HL and the studied 1:1 and 1:2 complexes were investigated theoretically at the DFT-B3LYP/6-311G** level of theory. The compounds were screened against various strains of bacteria and fungi. They displayed good results for inhibition against the studied pathogenic microorganisms. Absorption spectroscopic, viscosity and gel electrophoresis measurements were used for studying the interaction of the prepared complexes with calf thymus DNA (CT-DNA). The studied complexes showed a good interaction with CT-DNA via intercalation and groove modes. Moreover, molecular docking of these complexes was studied to understand the drug-DNA interactions and calculate the potential binding mode and energy. The anticancer effects of HL and its complexes, on selected human carcinoma cell lines, were determined. The cytotoxicity results showed that the prepared complexes are more potent than the Schiff base ligand.

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

\frac{[DNA]}{ε_{a} - ε_{f}} = ([], DNA) \frac{1}{ε_{b} - ε_{f}} + \frac{1}{K_{normalb}} \frac{1}{ε_{b} - ε_{f}}

Section: Methodsmentioning

confidence: 99%

“…K b was calculated from the ratio of slope to intercept of this plot. Δ G b ≠ (standard Gibbs free energy) for DNA binding was calculated from the following equation :

normalΔ G_{b}^{\neq} = - italicRT ln K_{b}

…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Synthesis, theoretical investigations, biocidal screening, DNA binding, in vitro cytotoxicity and molecular docking of novel Cu (II), Pd (II) and Ag (I) complexes of chlorobenzylidene Schiff base: Promising antibiotic and anticancer agents

Abdel‐Rahman

Adam

Abu‐Dief

et al. 2018

145

Multispectroscopic DNA interaction and Docking studies

Shekhar

Vasantha

Kumar

et al. 2018

Two new water soluble oxovanadium(IV) complexes with formulae Na[VO(his) (met)SO 4 ] (1) and Na[VO(gly)(met)SO 4 ] (2), (gly=glycine his=histidine, and met=metformin) were synthesized and characterized by LCMS, UV-Visible absorption, infrared spectra, magnetic moment, elemental analysis, thermal analysis and electronic spectral studies. The metal center was found in an octahedral geometry. DNA binding interaction of these complexes with CT DNA has been explored by UV-Visible absorption, fluorescence, viscosity measurements and cleavage studies. Finally the binding of the complexes with CT-DNA could be surface binding, mainly in the groove binding. The complexes were docked in to B-DNA sequence, 5

Ionic metallo‐Schiff base polymers of VO²⁺, Zn²⁺ and Cu²⁺: Synthesis, characterization and solid‐state conductivity

Ghavami

Grivani

2019

The viologen‐type dialdehyde of [N,N′‐bis(methylsalicylaldehyde)‐4,4′‐bipyridinium] dichloride (DA) was synthesized by reacting 5‐chloromethylsalicylaldehyde and 4,4′‐bipyridine. Then a new polymeric Schiff base ligand (PSBL) was synthesized by the condensation reaction of ethylenediamine and DA in methanol under reflux conditions. Afterwards, new ionic metallo‐Schiff base polymers (IMSPs) were synthesized by reacting PSBL with VO(acac)2, ZnCl2 and CuCl2 via coordination chelation. DA, PSBL and IMSPs were characterized using various analytical methods and spectral techniques. The solid‐state electrical conductivities of PSBL and IMSPs were studied. The electrical conductivity of these polymers at 300 K ranged from 1.30 × 10−5 to 4.52 × 10−10 Ω−1 m−1, which means they are potential organic and metallo‐organic semiconductors.