Kinetic studies on copper(II) complexes with 1,5-diazacyclooctane (= daco): Uncatalyzed and base-catalyzed acid dissociation of Cu(daco)22+ and ligand replacement by EDTA

Fecher, B.; Elias, Horst

doi:10.1016/s0020-1693(00)80940-8

Cited by 8 publications

References 13 publications

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Telescoping the Synthesis of the [¹⁸F]CABS13 Alzheimer's Disease Radiopharmaceutical via Flow Microfluidic Rhenium(I) Complexations

et al. 2020

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The syntheses of rhenium(I) complexes were achieved under flow microfluidic conditions. The use of a single microreactor was applied towards complexation of the 6‐chloro‐2,2'‐bipyridine diimine ligand, with ideal complexation conditions around 170 °C. Subsequent radiolabelling with [18F]fluoride was further achieved by flowing through a second heated microreactor, alongside a stream of dried radiofluorination media. Temperature modulation across both microreactors resulted in 23.6 % and 37.0 % radiochemical yield (RCY) of [18F]6‐fluoro‐2,2'‐bipyridine and its associated [18F]tricarbonyl(2‐fluoro‐2,2'‐bipyridine)rhenium(I) chloride complex, respectively. Translation of this set‐up to the synthesis of the [18F]CABS13 Alzheimer's disease positron emission tomography (PET) imaging agent was achieved with the incorporation of a third microreactor to enable thermal control of the complexation, fluorination and decomplexation pathways. Optimal RCYs of 2.7 % and 1.9 % of [18F]CABS13 and its rhenium(I) complexation were achieved in‐flow, respectively. However, discrepancies in the RCYs were found to arise from differences in the grade of anhydrous dimethyl sulfoxide (DMSO) employed in the continuous‐flow reactions. Anhydrous DMSO from Sigma‐Aldrich (≤ 99.9 %) in former experiments afforded higher yielders in comparison to replicate experiments employing anhydrous DMSO from Merck Millipore (≤ 99.7 %), thus demonstrating that control of the solvent grade is key to optimizing reaction RCYs.

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Telescoping the Synthesis of the [¹⁸F]CABS13 Alzheimer's Disease Radiopharmaceutical via Flow Microfluidic Rhenium(I) Complexations

et al. 2020

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Kinetics and mechanism of ligand substitution in binuclear nickel(II) and cobalt(II) complexes

Hynes

Doody

1995

Int J of Chemical Kinetics

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The kinetics and mechanism of the removal of M2+ from bis-(heptane-2,4,6-trionato)M(II) [M = Ni, Co] by ethylenediminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), 1,2-cyclohexanediamine-N, N, N', N'-tetraacetic acid (CyDTA), and ethylenebis(oxyethylenenitri1o)tetraacetic acid (EGTA) have been investigated using stopped-flow spectrophotometry in methanol-water at 25°C and ionic strength 0.1 mol dmp3 KNO3. The reactions were investigated at a number of different pHs.An associative mechanism is proposed to account for the kinetic data. Although all the ligands have similar functional groups, their reactivity towards the parent complex is quite different. The pH dependence of the rate constants has been used to determine the relative reactivities of the various ligand species present. In the case of nitrilotriacetic acid, a nonlinear dependence on ligand concentration is observed, thus confirming the mechanism proposed. 0

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Substitution Reactions of Inert-Metal Complexes—Coordination Numbers 6 and Above: Other Inert Centers

Twigg¹

1991

Mechanisms of Inorganic and Organometallic Reactions Volume 7

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Kinetic studies on copper(II) complexes with 1,5-diazacyclooctane (= daco): Uncatalyzed and base-catalyzed acid dissociation of Cu(daco)22+ and ligand replacement by EDTA

Cited by 8 publications

References 13 publications

Telescoping the Synthesis of the [¹⁸F]CABS13 Alzheimer's Disease Radiopharmaceutical via Flow Microfluidic Rhenium(I) Complexations

Telescoping the Synthesis of the [¹⁸F]CABS13 Alzheimer's Disease Radiopharmaceutical via Flow Microfluidic Rhenium(I) Complexations

Kinetics and mechanism of ligand substitution in binuclear nickel(II) and cobalt(II) complexes

Substitution Reactions of Inert-Metal Complexes—Coordination Numbers 6 and Above: Other Inert Centers

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Kinetic studies on copper(II) complexes with 1,5-diazacyclooctane (= daco): Uncatalyzed and base-catalyzed acid dissociation of Cu(daco)22+ and ligand replacement by EDTA

Cited by 8 publications

References 13 publications

Telescoping the Synthesis of the [18F]CABS13 Alzheimer's Disease Radiopharmaceutical via Flow Microfluidic Rhenium(I) Complexations

Telescoping the Synthesis of the [18F]CABS13 Alzheimer's Disease Radiopharmaceutical via Flow Microfluidic Rhenium(I) Complexations

Kinetics and mechanism of ligand substitution in binuclear nickel(II) and cobalt(II) complexes

Substitution Reactions of Inert-Metal Complexes—Coordination Numbers 6 and Above: Other Inert Centers

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Product

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Telescoping the Synthesis of the [¹⁸F]CABS13 Alzheimer's Disease Radiopharmaceutical via Flow Microfluidic Rhenium(I) Complexations

Telescoping the Synthesis of the [¹⁸F]CABS13 Alzheimer's Disease Radiopharmaceutical via Flow Microfluidic Rhenium(I) Complexations