Kinetic Studies of the Interaction Between Isoniazid and Reducing Sugars

Behavior of Decomposition of Rifampicin in the Presence of Isoniazid in the pH Range 1–3

“…This is in accordance with the initial Data are mean AE s.d., n ¼ 6. expectation that formation of hydrazone from decomposition of rifampicin in the presence of isoniazid should run parallel to the formation of hydrazone between isoniazid and reducing sugars, where also bell-shaped behavior was observed. [7] As seen in Fig. 3, the slope of the curve is steep in the pH range 1.5-2 and then falls as the pH is increased further.…”

“…It was previously established that rifampicin degrades in the presence of isoniazid under acid conditions through a reaction involving formation of isonicotinyl hydrazone, which results from an interaction of isoniazid with 3-formylrifamycin, an acid degradation product of rifampicin. [6] Based upon the work by Devani et al, [7] where a bell-shaped pH curve is reported for the parallel formation of isonicotinyl hydrazone between isoniazid and reducing sugars, it was anticipated that decomposition of rifampicin in the presence of isoniazid would also show a similar behavior, showing a fall in the decomposition curve after reaching the maximum. Hence the study was extended, to establish a pH profile for the decomposition of rifampicin in the presence of isoniazid, in the pH range 1-3.…”

Synthesis, characterization and catalytic applications of rhodium(I) organometallics with substituted tertiary phosphines

“…1,2-naphthaquinone-4-sulfonate [22], p-benzoquinone [23] and trisodium pentacyanoaminoferrate [24]. Since, b-naphthol produces high molar absorptivity value, it was preferred for the color development.…”

Synthesis, spectral studies and catalytic activity of ruthenium(II) complexes with organic amide ligands

“…Acetic acid is preferred over HCl and formic acid because of better yields. In addition, the formed amino derivatives were determined by diazotization reaction with β-naphthol, 24 along with other color reagents such as trisodium pentacyanoaminoferrate, 22 Pbenzoquinone 37 and 1,2-naphthaquinone-4-sulfonate. 25 As β-naphthol produces a high molar absorptivity value, it was preferred for color development ( Table 5).…”

“…chloramphenicol (CP) and metronidazole (MZ), were selected. Literature survey reveals that chloramphenicol is reduced by metal-containing combinations such as Zn-HCl 22 and titanium(III) chloride-glacial acetic acid 23 to produce reduced chloramphenicol (RCP). Similarly, metronidazole is reduced by Zn-HCl 24 and Pd-C(10%)-formic acid 25 to produce reduced metronidazole (RMZ).…”