Kinetic stability of amorphous solid dispersions with high content of the drug: A fast scanning calorimetry investigation

Lapuk, Semen E.; Zubaidullina, Liana S.; Зиганшин, Марат А.; Mukhametzyanov, Timur A.; Schick, Christoph; Gerasimov, Alexander V.

doi:10.1016/j.ijpharm.2019.03.039

Cited by 29 publications

(17 citation statements)

References 60 publications

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“…Scans were performed in a dynamic argon atmosphere with a 50 mL·min –1 flow rate. The typical sample mass is between 10 and 50 ng; the sample was placed directly on the calorimetric chip in the central rectangular region (150 × 150 μm) of the heated area to avoid contact with the heaters or the edges of the heated area. − …”

Section: Methodsmentioning

confidence: 99%

Glass Transition Kinetics and Physical Aging of Polyvinylpyrrolidones with Different Molecular Masses

et al. 2022

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The stability of glassy materials, including polymer-based ones, is one of the important subjects of material science and technology. This interest is due to the dependence of the properties of the end products, based on glassy materials, on the processing and storage conditions. In particular, the application of amorphous solid dispersions based on polymer excipients requires an understanding of the kinetics of the formation and the physical aging of the glassy state. The kinetic parameters of the glass transition of polyvinylpyrrolidone, a widely used polymer in the pharmaceutical industry, were determined in the present work using fast scanning calorimetry. The dependencies of the Vogel temperature and the kinetic fragility on the molecular mass of the polymer were determined, as well as the apparent activation energy of the physical aging process, which changes from 256 kJ·mol–1 in the case of polyvinylpyrrolidone with a molecular mass of 3500 g·mol–1 to 565 kJ·mol–1 in the case of polyvinylpyrrolidone with a molecular mass of 1,300,000 g·mol–1. The results of the current work can be used to optimize the processing of polymer-based glassy materials to obtain the desired properties for application in different fields of technology, including pharmaceuticals.

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Section: Methodsmentioning

confidence: 99%

Glass Transition Kinetics and Physical Aging of Polyvinylpyrrolidones with Different Molecular Masses

et al. 2022

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“…During this work, we studied the process of heavy oil oxidation and the relation between the nature of the transition metal and the ligands in the catalyst system in addition to their effect on the kinetic parameters of the process of oil oxidation based on the recommendations of ICTAC. To determine the kinetic parameters, the isoconversional and model approaches of nonisothermal kinetics were used. , All isoconversional methods originate from the isoconversional principle, which states that the reaction rate at a constant conversion is only a function of temperature. The following isoconversional approaches were used in the present work: Kissinger’s method (ASTM E2890), Friedman’s analysis, and the Kissinger–Akahira–Sunose method.…”

Section: Methodsmentioning

confidence: 99%

“…To determine the kinetic parameters, the isoconversional and model approaches of nonisothermal kinetics were used. 48,49 All isoconversional methods originate from the isoconversional principle, which states that the reaction rate at a constant conversion is only a function of temperature. The following isoconversional approaches were used in the present work: Kissinger's method (ASTM E2890), 50 Friedman's analysis, 51 and the Kissinger−Akahira−Sunose method.…”

Section: ■ Introductionmentioning

confidence: 99%

Effect of Ligand Structure on the Kinetics of Heavy Oil Oxidation: Toward Biobased Oil-Soluble Catalytic Systems for Enhanced Oil Recovery

Farhadian

Khelkhal

Tajik

et al. 2021

Ind. Eng. Chem. Res.

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In recent years, protection of the environment from activities associated with enhanced oil recovery has been considered a crucial priority for decision-makers in the international community. The in situ combustion process as a promising thermal enhanced oil recovery method has been attracting considerable interest in terms of improving oil production and environmental protection. However, this technique is not yet well studied. This paper outlines a new approach to improve the process of heavy oil oxidation by designing new biobased oil-soluble catalysts that are able to maintain and stabilize the combustion flame front of the in situ combustion process. A comprehensive theoretical and experimental study including thermal analysis (thermogravimetry/differential scanning calorimetry, TG/DSC) and quantum calculations was used to shed light on the effect of the ligand structure in the oil-soluble catalytic system on the heavy oil oxidation process. The obtained accurate results proved that metal interaction with the designed ligands increased, which led to a decrease in the energy of activation and an increase in the heavy oil oxidation reaction rate. Besides, the obtained DSC curves showed one peak in the presence of Cu and biobased ligands, contrary to the curves obtained for heavy oil oxidation reported with other ligands and metals. In other words, the obtained catalysts merged low-temperature-and high-temperature oxidation regions into one region. These findings reveal that the structure of ligands can significantly affect their interaction with metals in oil-soluble catalysts, and therefore the efficiency of catalysts is dramatically improved. We believe that our work could be usefully employed for further studies to clarify the mechanism of the in situ combustion behavior of heavy oil for a better impact on the environment.

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“…The aim of the present study was to reveal the oxidation behavior of peat from a kinetic analysis perspective. Consequently, the isoconversional and model approaches of non-isothermal kinetics [39,40], in addition to the Kissinger method [41], were selected to study the kinetic behavior of the peat oxidation process as recommended by the Kinetics Committee of the International Confederation for Thermal Analysis and Calorimetry (ICTAC) [39].…”

Section: Kinetic Analysismentioning

confidence: 99%

A Thermal Study on Peat Oxidation Behavior in the Presence of an Iron-Based Catalyst

et al. 2021

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Peat is a resource used for heat and energy, particularly in countries where peat is abundant and conventional fuels are not available. Some countries have made extensive use of peat resources to produce electricity and heat in addition to light hydrocarbons. By doing so, they were able to reduce the cost of importing fossil fuels. To the best of our knowledge, there is a lack of a detailed description of the peat oxidation process in the presence of other substances. Herein, the process of peat oxidation was studied in-depth by means of thermal analysis in the presence of iron tallate acting as a catalytic agent. Differential scanning calorimetry and thermogravimetric analysis demonstrated an oil-like oxidation behavior during the combustion of the used peat. The process of peat oxidation includes two main regions: low-temperature oxidation (LTO), which occurs during the oxidation of light hydrocarbons, followed by the so-called high-temperature oxidation (HTO), which includes the oxidation of the obtained coke-like product. Moreover, the application of non-isothermal kinetics experiments based on the isoconversional and model approach principle have confirmed the role of 2% iron tallate in peat mass by improving the oxidation rate at low- and high-temperature oxidation (HTO) regions. The results obtained from this study have proven that the added catalyst improves efficiency with regards to the energy activation in the process by leading to its significant decrease from 110.8 ± 7.8 kJ/mol to 81.8 ± 7.5 kJ/mol for LTO and from 157.8 ± 19.1 kJ/mol to 137.6 ± 9.3 kJ/mol for HTO. These findings clearly confirm the improvement in the rate of the process by shifting the LTO and HTO peaks to lower regions in the presence of the catalyst. These results further emphasize the possible impact which could be generated by the application of thermally enhanced oil recovery methods on peat development and exploitation.

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Kinetic stability of amorphous solid dispersions with high content of the drug: A fast scanning calorimetry investigation

Cited by 29 publications

References 60 publications

Glass Transition Kinetics and Physical Aging of Polyvinylpyrrolidones with Different Molecular Masses

Glass Transition Kinetics and Physical Aging of Polyvinylpyrrolidones with Different Molecular Masses

Effect of Ligand Structure on the Kinetics of Heavy Oil Oxidation: Toward Biobased Oil-Soluble Catalytic Systems for Enhanced Oil Recovery

A Thermal Study on Peat Oxidation Behavior in the Presence of an Iron-Based Catalyst

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