Kinetic spectrophotometric method for the determination of perindopril erbumine in pure and commercial dosage forms

Rahman, Nafisur; Rahman, Habibur; Haque, Sk Manirul

doi:10.1016/j.arabjc.2012.12.017

Cited by 18 publications

(7 citation statements)

References 16 publications

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“…Because KMnO4 is a strong oxidizing agent and formed manganite ion. The oxidation no of Mn changes from +7 (purple) to +6 (green) and the metformin converted to metformin N-oxide 47 (Scheme 1). The colored product was measured after 5 minutes, and metformin can be determined in its pure solid form as well as in pharmaceutical formulations.…”

Section: Resultsmentioning

confidence: 99%

Development, Computational Studies and Validation of Spectrophotometric Method of Metformin Hydrochloride in Pharmaceutical Formulations

Judeh

Sarief

Umar

et al. 2020

J. Chil. Chem. Soc.

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Simple, fast, and sensitive spectrophotometric method was developed for the determination of metformin in pharmaceutical formulations. The spectrophotometric procedure was based on the oxidation of metformin with potassium permanganate in alkaline medium. The developed method was also validated according to International Conference on Harmonization guidelines parameters such as linearity, accuracy, precision, limit of detection and quantitation. Studies were conducted to investigate different parameters involved in color developments and optimized. The pure drug of metformin was extracted from a pharmaceutical dosage form. The extraction procedure was developed, and a possible reaction mechanism proposed in the manuscript. The IR spectrum of the extracted metformin was taken and compared with the simulated IR spectrum obtained from the density functional theory calculation. The vibrational assignment of the modes was done based on potential energy distribution.

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Section: Resultsmentioning

confidence: 99%

Development, Computational Studies and Validation of Spectrophotometric Method of Metformin Hydrochloride in Pharmaceutical Formulations

Judeh

Sarief

Umar

et al. 2020

J. Chil. Chem. Soc.

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“…Figure S10 in supplementary file demonstrates the effect of H2SO4 concentration on absorbance difference upon addition of QTF to ceric. For method I, previous studies for oxidation with alkaline permanganate endorse reaction at room temperature due to poor reproducibility obtained upon application of elevated temperatures [20][21][22][23][24]. Consequently, the effect of temperature on the measured signal was studied only in methods II and III.…”

Section: Reaction Conditions Optimizationmentioning

confidence: 99%

The Use of Green Spectroscopy for Analysis of Quetiapine

et al. 2020

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Three green (eco-friendly), inexpensive and simple spectrophotometric methods for quetiapine fumarate (QTF) analysis have been developed and validated. Method I is based on the measurement of the oxidation product of QTF at 610 nm after the reaction with potassium permanganate. Potassium permanganate was used as oxidant. Method II depends on oxidation of the cited drug with ceric ammonium sulfate where the decrease in absorption intensity at 315 nm was measured quantitively. Method III involves complexation of the studied analyte with 2´,7´-bis (acetoxymercury) fluorescein leading to a quantitative decrease in the absorption intensity of the complexing reagent at 502 nm. Different reaction conditions affecting intensity of measurement were carefully studied, optimized and validated. In all proposed methods, no need for extraction procedures and there were linear relationships between the absorbance readings and concentrations of QTF in the range of 5-35, 1-6 and 30-100 μg/mL with LOD values 1.11, 0.12 and 2.68 μg/mL for methods I, II and III respectively. The suggested methods were successfully applied to QTF analysis in pure form and in drug tablets.

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“…Such synergistic coupling through multi-component integration lowers the Ohmic losses and contributes to unprecedented SPCE enhancements. Furthermore, the sharply directional, highly polarized, and enhanced emissions enable reliable and ultrasensitive detection of pharmacologically important drug (perindopril erbumine, PE) at single-molecular levels (0.1 attomolar) through a mobile phone-based platform, presenting an important capability for treatment of hypertension and myocardial infarction. − Thus, the materials and design principles illustrated in this report provide newer fundamental insights for achieving non-plasmonic and yet augmented SPCE enhancements, leading to versatile point-of-care diagnostic platforms.…”

Section: Introductionmentioning

confidence: 97%

Metal–Dielectric Interfacial Engineering with Mesoporous Nano-Carbon Florets for 1000-Fold Fluorescence Enhancements: Smartphone-Enabled Visual Detection of Perindopril Erbumine at a Single-molecular Level

Bhaskar

Thacharakkal

Ramamurthy

et al. 2022

ACS Sustainable Chem. Eng.

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Metallic nanosystems with strong surface plasmon resonance have been a predominant choice for surface plasmoncoupled emission (SPCE), leading to a plethora of sensing and diagnostic applications. The Ohmic losses and strong isotropic scattering of the emissive photons in such systems still remain major challenges that limit the sensitivity, reliability, and magnitude of enhancements. Consequently, rational designing of nonplasmonic dielectric interfaces and their hybrids that suppress these drawbacks without compromising the radiative decay pathways is highly desirable. Here, we present dielectric-based nanostructured carbon florets (NCFs), exhibiting precisely tailored porosities and surface morphologies for enhanced light entrapment, thereby achieving plasmon-free generation of electromagnetic (EM) hotspots. The hard-carbon sp 2 framework of NCF, together with its morphology resembling conical microcavities, thus represents the first all-carbon system, providing 310-fold SPCE enhancements. Such enhancements achieved in cavity configuration present a fundamental departure from those obtained through conventional plasmonic interfaces that work best in spacer and extended cavities. This underlines the importance of the extensive surface area (745.62 m 2 /g) and high absorbance (>0.9) of NCF. Besides showcasing the detailed morphological dependence of SPCE, the NCF also acts as a versatile support for anchoring plasmonic Ag and interfacing with π-plasmon rich GO. Such a multi-component hybrid combines the benefits of several radiative pathways for realizing unprecedented 1000-fold SPCE enhancements. Consequently, this substrate has been utilized for the detection of pathologically important PE at single-molecular attomolar levels (1 × 10 −19 M) with excellent linearity (R 2 = 0.996) and high reliability (RSD: 2.07) over a wide concentration range spanning 16 orders of magnitude (0.1 aM−1 mM). The demonstration of such detection with smartphone-based platforms expands opportunities for the internet-of-things, besides unraveling newer possibilities for metal−dielectric interfacial engineering.

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Kinetic spectrophotometric method for the determination of perindopril erbumine in pure and commercial dosage forms

Cited by 18 publications

References 16 publications

Development, Computational Studies and Validation of Spectrophotometric Method of Metformin Hydrochloride in Pharmaceutical Formulations

Development, Computational Studies and Validation of Spectrophotometric Method of Metformin Hydrochloride in Pharmaceutical Formulations

The Use of Green Spectroscopy for Analysis of Quetiapine

Metal–Dielectric Interfacial Engineering with Mesoporous Nano-Carbon Florets for 1000-Fold Fluorescence Enhancements: Smartphone-Enabled Visual Detection of Perindopril Erbumine at a Single-molecular Level

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