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image [863024‐69‐5] C 20 H 12 ClO 2 PSe (MW 429.71) InChI = 1S/C20H12ClO2PSe/c21‐24(25)22‐17‐11‐9‐13‐5‐1‐3‐7‐15(13)19(17)20‐16‐8‐4‐2‐6‐14(16)10‐12‐18(20)23‐24/h1‐12H InChIKey = WZQNXJRLUUZRMH‐UHFFFAOYSA‐N 4‐Chloro‐(11b R )‐dinaphtho[2,1‐d:1′,2′‐f][1,3,2]dioxaphosphepin‐4‐selenide image [863024‐82‐2] C 20 H 12 ClO 2 PSe (MW 429.71) InChI = 1S/C20H12ClO2PSe/c21‐24(25)22‐17‐11‐9‐13‐5‐1‐3‐7‐15(13)19(17)20‐16‐8‐4‐2‐6‐14(16)10‐12‐18(20)23‐24/h1‐12H InChIKey = WZQNXJRLUUZRMH‐UHFFFAOYSA‐N 4‐Chloro‐(11b S )‐dinaphtho[2,1‐d:1′,2′‐f][1,3,2]dioxaphosphepin‐4‐selenide Physical Data : white solid; mp 240–241 °C. Solubility : stably soluble in aprotic organic solvents. Form Supplied in : not commercially available. Analysis of Reagent Purity : IR (KBr): 3006, 1588, 1509, 1460, 1433, 1355, 1214, 1190, 1157, 1142, 1067, 969, 946, 868, 840, 806, 769, 749, 705, and 652 cm −1 ; 1 H NMR (CDCl 3 ): d 7.22–8.32 (m, 12 H , C 20 H 12 ); 13 C NMR (CDCl 3 ): d 120.4, 121.1, 122.4, 122.6, 126.3, 126.9, 127.0, 127.1, 127.2, 128.7, 131.3, 131.4, 132.0, 132.2, 132.3, 132.5, 146.5, 146.6, 147.8, and 148.0 (Ar); 31 P NMR (CDCl 3 ): d 69.0 ( 1 J P‐Se = 1060.9 Hz); 77 Se NMR (CDCl 3 ): δ −69.2 (d, 1 J P‐Se = 1060.9 Hz). Preparative Method : phosphorus trichloride in toluene solution was treated with triethylamine, ( R ax )‐1,1′‐bi‐2‐naphthol (8.58 g, 30 mmol), and powdered selenium. 1,2 Purification : purified by column chromatography on silica gel with hexane:CH 2 Cl 2 as the eluent. Handling, Storage, and Precautions : the product can be stored for long periods below room temperature under an inert gas atmosphere. In some cases, the product exhibits pink color, which is indicative of the contamination of amorphous selenium, but it can be used for further reaction. Additionally, it gradually hydrolyzes on exposure to moisture in the air. Incompatible with strong acids, strong bases, oxidizing, and reducing agents.
image [863024‐69‐5] C 20 H 12 ClO 2 PSe (MW 429.71) InChI = 1S/C20H12ClO2PSe/c21‐24(25)22‐17‐11‐9‐13‐5‐1‐3‐7‐15(13)19(17)20‐16‐8‐4‐2‐6‐14(16)10‐12‐18(20)23‐24/h1‐12H InChIKey = WZQNXJRLUUZRMH‐UHFFFAOYSA‐N 4‐Chloro‐(11b R )‐dinaphtho[2,1‐d:1′,2′‐f][1,3,2]dioxaphosphepin‐4‐selenide image [863024‐82‐2] C 20 H 12 ClO 2 PSe (MW 429.71) InChI = 1S/C20H12ClO2PSe/c21‐24(25)22‐17‐11‐9‐13‐5‐1‐3‐7‐15(13)19(17)20‐16‐8‐4‐2‐6‐14(16)10‐12‐18(20)23‐24/h1‐12H InChIKey = WZQNXJRLUUZRMH‐UHFFFAOYSA‐N 4‐Chloro‐(11b S )‐dinaphtho[2,1‐d:1′,2′‐f][1,3,2]dioxaphosphepin‐4‐selenide Physical Data : white solid; mp 240–241 °C. Solubility : stably soluble in aprotic organic solvents. Form Supplied in : not commercially available. Analysis of Reagent Purity : IR (KBr): 3006, 1588, 1509, 1460, 1433, 1355, 1214, 1190, 1157, 1142, 1067, 969, 946, 868, 840, 806, 769, 749, 705, and 652 cm −1 ; 1 H NMR (CDCl 3 ): d 7.22–8.32 (m, 12 H , C 20 H 12 ); 13 C NMR (CDCl 3 ): d 120.4, 121.1, 122.4, 122.6, 126.3, 126.9, 127.0, 127.1, 127.2, 128.7, 131.3, 131.4, 132.0, 132.2, 132.3, 132.5, 146.5, 146.6, 147.8, and 148.0 (Ar); 31 P NMR (CDCl 3 ): d 69.0 ( 1 J P‐Se = 1060.9 Hz); 77 Se NMR (CDCl 3 ): δ −69.2 (d, 1 J P‐Se = 1060.9 Hz). Preparative Method : phosphorus trichloride in toluene solution was treated with triethylamine, ( R ax )‐1,1′‐bi‐2‐naphthol (8.58 g, 30 mmol), and powdered selenium. 1,2 Purification : purified by column chromatography on silica gel with hexane:CH 2 Cl 2 as the eluent. Handling, Storage, and Precautions : the product can be stored for long periods below room temperature under an inert gas atmosphere. In some cases, the product exhibits pink color, which is indicative of the contamination of amorphous selenium, but it can be used for further reaction. Additionally, it gradually hydrolyzes on exposure to moisture in the air. Incompatible with strong acids, strong bases, oxidizing, and reducing agents.
This chapter describes the synthesis and applications of four-coordinate pentavalent organophosphorus compounds with a PSe group, including: (i) the addition reaction of secondary phosphine selenides; (ii) Woollins’ reagent as a selenating agent and its derivatizations to the compounds containing phosphorus and selenium atoms; (iii) chiral phosphoroamidites as Lewis base catalysts; and (iv) PSe compounds with a binaphthyl group as a chiral transfer reagent.
Novel synthetic methods for P-chirogenic four-coordinate pentadentate organophosphorus compounds are described. The synthetic pathways commenced with the use of phosphates bearing a binaphthyl group and their congeners. These compounds underwent reactions with fluoride ion, metal hydroxides, metal alkoxides, and Grignard reagents, resulting in the transfer of axial chirality from the binaphthyl group to the central chirality of the phosphorus atom. As a result, P-chirogenic products incorporating a binaphthyl group were obtained. The substitution reactions of these newly formed products with metal alkoxides and Grignard reagents led to the formation of P-chirogenic phosphates, phosphonates, phosphinates, and some sulfur isologues.
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