Kinetic Modelling in Human Brain Imaging

Nelissen, Natalie; JamesWarwick,; Dupont, Patrick

doi:10.5772/30052

Cited by 3 publications

(3 citation statements)

References 36 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All kinetic modeling was performed with PMOD’s Kinetic Tool (version 3.405) and comparisons between the models were done according to a commonly used methodology. [ 30 ] The volume of distribution (V T ), representing the ratio of the concentration of radiotracer in a particular ROI to the concentration in plasma at equilibrium, and related standard error coefficients of variation (COV), were calculated for each ROI based on two standard full kinetic compartmental models, the single- and two-tissue compartment (1-TC and 2-TC) model [ 31 , 32 ], and a graphical analysis technique, the Logan plot [ 33 ]. The derivations, at equilibrium, of the relationship between the rate constants and V T can be calculated as follows [ 34 ]:…”

Section: Methodsmentioning

confidence: 99%

“…Thereby, the BP ND and COV was calculated for each ROI using a fixed k 2 ’ value representing the tissue clearance rate from the reference region. For MRTM2, MRTM [ 31 , 42 ] was used to calculate k 2 ’ and for SRTM2 and the Logan reference tissue model, SRTM [ 31 , 40 ] was used to calculate k 2 ’. In both cases, a fixed k 2 ’ was determined as the mean value of five high binding regions: raphe nuclei, thalamus left, thalamus right, basal ganglia left and basal ganglia right.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

In Vivo Evaluation of Blood Based and Reference Tissue Based PET Quantifications of [11C]DASB in the Canine Brain

et al. 2016

View full text Add to dashboard Cite

This first-in-dog study evaluates the use of the PET-radioligand [11C]DASB to image the density and availability of the serotonin transporter (SERT) in the canine brain. Imaging the serotonergic system could improve diagnosis and therapy of multiple canine behavioural disorders. Furthermore, as many similarities are reported between several human neuropsychiatric conditions and naturally occurring canine behavioural disorders, making this tracer available for use in dogs also provide researchers an interesting non-primate animal model to investigate human disorders. Five adult beagles underwent a 90 minutes dynamic PET scan and arterial whole blood was sampled throughout the scan. For each ROI, the distribution volume (VT), obtained via the one- and two- tissue compartment model (1-TC, 2-TC) and the Logan Plot, was calculated and the goodness-of-fit was evaluated by the Akaike Information Criterion (AIC). For the preferred compartmental model BPND values were estimated and compared with those derived by four reference tissue models: 4-parameter RTM, SRTM2, MRTM2 and the Logan reference tissue model. The 2-TC model indicated in 61% of the ROIs a better fit compared to the 1-TC model. The Logan plot produced almost identical VT values and can be used as an alternative. Compared with the 2-TC model, all investigated reference tissue models showed high correlations but small underestimations of the BPND-parameter. The highest correlation was achieved with the Logan reference tissue model (Y = 0.9266 x + 0.0257; R2 = 0.9722). Therefore, this model can be put forward as a non-invasive standard model for future PET-experiments with [11C]DASB in dogs.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

In Vivo Evaluation of Blood Based and Reference Tissue Based PET Quantifications of [11C]DASB in the Canine Brain

et al. 2016

View full text Add to dashboard Cite

show abstract

“…There are several pharmacokinetic (PK) approaches in PET imaging techniques, of which compartmental modeling has been used to simulate the physiologically significant parameters. In compartmental models, the organ of interest is composed of many interacting subsystems (compartments) with a set of transfer rate constants describing the exchanges of mass or material between the compartments ( 17 , 18 , 19 , 20 , 21 , 22 ). Wahl and Nahmias ( 22 ) published a simplified two-tissue compartment, three-rate constant 18 F-FDOPA kinetic model by eliminating the fourth transfer rate constant and the number of compartments.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Modeling of <sup>18</sup>F-FDOPA PET in the Human Brain for Early Parkinson’s Disease

Buratachwatanasiri

Chantadisai

Onwanna

et al. 2021

Mirt

View full text Add to dashboard Cite

Objectives: Early detection is essential for the treatment approaches of Parkinson’s disease (PD). Clinical criteria alone may be insufficient to distinguish early PD from other conditions. This study aimed to investigate the transfer rate constants of 6- 18 F-fluoro-L-dopa ( 18 F-FDOPA) in positron emission tomography (PET) brain images as a sensitive parameter to detect early PD. Methods: Retrospective 18 F-FDOPA PET data of five patients with early PD were collected. PET data were acquired for 90 min after intravenous injection of 306-379 MBq 18 F-FDOPA, and reconstructed into a series of 18 five-minute frames. Reoriented PET images were coregistered and normalized with the PET brain template on the statistical parametric mapping. The 18 F-FDOPA activity concentrations were measured in the striatum, caudate, and putamen on both sides: Contralateral (as PD) and ipsilateral (as control) to the main motor symptoms. The pharmacokinetic model was generated using the SAAM II simulation software. The transfer rate constants across the blood-brain barrier (forward, K 1 and reverse, k 2 ) and decarboxylation rate constants (k 3 ) were estimated in these regions. Results: The activity uptakes in the contralateral striatum (0.0323%±0.0091%) and putamen (0.0169%±0.0054%) were significantly lower than the control (0.0353%±0.0086%, 0.0199%±0.0054%, respectively). The K 1 and k 3 were significantly lower in the contralateral striatum and putamen (p<0.05). There were no significant differences in any transfer rate constants in the caudate. Conclusion: The transfer rate constants (K 1 and k 3 ) of 18 F-FDOPA on the contralateral striatum and putamen were significantly lower than the control. These biokinetic data could be potential indicators for quantitative detection of early PD diagnosis.

show abstract

Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated

Yoon

Son

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Little is known about whether early-phase PET images of 18F-FP-CIT match those of amyloid PET. Here, we compared early-phase 18F-FP-CIT and 18F-flutemetamol PET images in patients who underwent both within a 1-month interval. The SUVR on early-phase 18F-FP-CIT PET (median, 0.86) was significantly lower than that of 18F-flutemetamol PET (median, 0.91, p < 0.001) for total brain regions including all cerebral lobes and central structures. This significant difference persisted for each brain region except central structures (p = 0.232). The SUVR of total brain regions obtained from early 18F-FP-CIT PET showed a very strong correlation with that of 18F-flutemetamol PET (rho = 0.80, p < 0.001). Among the kinetic parameters, only R1 showed a statistically significant correlation between the two techniques for all brain regions (rho = 0.89, p < 0.001). R1 from 18F-FP-CIT (median, 0.77) was significantly lower in all areas of the brain compared to R1 from 18F-flutemetamol PET (median, 0.81, p < 0.001).18F-FP-CIT demonstrated lower uptake in cortical brain regions than 18F-flutemetamol on early-phase PET. However, both early-phase PETs demonstrated significant correlation of uptake.

show abstract

Kinetic Modelling in Human Brain Imaging

Cited by 3 publications

References 36 publications

In Vivo Evaluation of Blood Based and Reference Tissue Based PET Quantifications of [11C]DASB in the Canine Brain

In Vivo Evaluation of Blood Based and Reference Tissue Based PET Quantifications of [11C]DASB in the Canine Brain

Pharmacokinetic Modeling of <sup>18</sup>F-FDOPA PET in the Human Brain for Early Parkinson’s Disease

Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated

Contact Info

Product

Resources

About