Kinetic modeling of lipase‐mediated one‐pot chemo‐bio cascade synthesis of R‐1‐phenyl ethyl acetate starting from acetophenone

Abstract

BACKGROUND: A systematic investigation of mutual interference between a hydrogenation catalyst, Pd/Al 2 O 3 , and an immobilized lipase in a one-pot synthesis of R-1-phenyl ethyl acetate at 70• C has been undertaken. This paper reports the kinetic modeling of lipase-mediated chemo-bio cascade synthesis of R-1-phenyl ethyl acetate starting from acetophenone.

Optimization and Modeling of Process Parameters for Lipase Production by Bacillus brevis

“…At minimum water activity, lipases can reverse the reaction to synthesize triacylglyceride from glycerol and free fatty acid. Therefore, lipases can catalyze a wide range of reactions such as hydrolysis, interesterification, esterification, alcoholysis, acidolysis, and aminolysis (Macrae and Hammond 1985); Ghosh et al 1996;Jaeger and Reetz 1998;Pandey et al 1999;Sahin et al 2010). Because of these novel characteristics, lipases find promising applications in organic chemical processing, detergent formulations, olechemical industry, dairy industry, agrochemical industry, paper manufacture, nutrition, cosmetic and pharmaceutical processing, and in the synthesis of biosurfactants (Sharma et al 2001).…”

Kinetics of Catalytic Reactions With Multiple/Multifunctional Catalysts

“…8.9, only the reactions leading to the main products, propene, isobutene, and pentenes, are depicted, while other reaction paths, such as hydrogenolysis and monomolecular butane racking are omitted, as the amount of by-products is minor. Monomolecular isobutene formation is included in route N (1) , while bimolecular isobutene formation is explained by route (N (3) ). The pentanes, isopentane and n-pentane, are lumped together, because both of them are (hydrogenated) cracking products (CPs) of C ¼ Steps A-D are considered to be quasi-equilibriated and correspond to adsorption of olefins on the acid sites proceeding via protonation by olefins.…”

Enhanced Electroreduction of Acetophenone Using Lipase Stabilization: Improved Conversion to 1‐Phenylethanol

“…In this sense, immobilized species are even more stable than their free counterparts, as they become rigid when confined to solid supports. [37] The materials used in the immobilization processes can be clay minerals, [38] silicas, [39][40][41] and a wide range of natural and synthetic materials, including biohybrid materials, [42,43] and the electrode of the electrosynthetic procedure itself, as it is usually used in preparing electrochemical biosensors. [44] This work studied the combination of electrochemistry with several lipases in the selective reduction of acetophenone to 1phenylethanol to avoid dimerization.…”

“…Lipases can generally be used under very different conditions, such as high temperatures, variable pH, and organic solvents. In this sense, immobilized species are even more stable than their free counterparts, as they become rigid when confined to solid supports [37] . The materials used in the immobilization processes can be clay minerals, [38] silicas, [39–41] and a wide range of natural and synthetic materials, including biohybrid materials, [42,43] and the electrode of the electrosynthetic procedure itself, as it is usually used in preparing electrochemical biosensors [44] …”