Kinetic modeling of dynamic processes in the cholinergic synapse

Варфоломеев, С. Д.; Bykov, V. I.; Цыбенова, С. Б.

doi:10.1007/s11172-020-2939-8

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…The first term of Equation ( 1) describes the Glu injection dynamics into the synaptic cleft (when modeling the kinetic features of cholinergic system functioning, a similar approach was used [1][2][3]). The second term of the Equation describes Glu dissipation and absorption dynamics in the synaptic cleft, including the neurotransmitter transfer into the astrocyte action system.…”

Section: Resultsmentioning

confidence: 99%

“…Kinetic modeling of the synapse functioning is an effective method to analyze the mechanism of synaptic transmission and the basis for creating methods of neurosystem control. A kinetic model of cholinergic synapse which is one of the basic elements of the brain neuronal system functioning has been developed [1][2][3]. Acetylcholinesterase -the enzyme that hydrolyzes acetylcholine, the neurotransmitter with choline and acetic acid formation -acts as the fundamental element in the mechanism of cholinergic synapse 'operation'.…”

Section: Introductionmentioning

confidence: 99%

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Kinetic model of the glutamate neuron-astrocytic system. N-acetylaspartylglutamate and glutamate carboxypeptidase

Varfolomeev,

Bykov,

Tsybenova

2023

Preprint

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Kinetic model of excitatory synapse functioning with glutamate and N-acetylaspartylglutamate (NAAG) as neurotransmitters in a three-component system regarding neuroglial astrocytic cells and the glutamate carboxypeptidase (GCPII) enzyme has been developed. The biphasic nature of the process providing excitation amplification within the modeling framework is shown. The role of excitatory synapse intensity has been investigated. The role of NAAG for enhancing neuronal connectivity and the realization of cognitive function is shown. The mechanism of cognition control by influencing on the efficiency of mGluR3 metabotropic receptor functioning is dis-cussed. The role of GCPII inhibition as a method of improving cognitive functions is studied. Dynamic features of the glutamatergic system behavior in neurodegenerative diseases (Alzheimer's disease, dementia), schizophrenia, traumatic brain injury, and epilepsy, as a part of development of the kinetic model are analyzed. The positive role of GCPII inhibition with the NAAG level increase as an effective approach to neuropathology treatment is shown.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kinetic model of the glutamate neuron-astrocytic system. N-acetylaspartylglutamate and glutamate carboxypeptidase

Varfolomeev,

Bykov,

Tsybenova

2023

Preprint

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“…The ability of H. scabrum extracts to participate in the nervous system care was examined by measuring their affinity to the inhibition of AChE and BChE. AChE is one of the most important enzymes in the transmission of nerve impulses as it hydrolyses acetylcholine, an important neurotransmitter for cognitive function and muscle contraction [39,40]. Further, BChE hydrolyses choline esters but does not have a direct role in nerve impulse transmission [41,42].…”

Section: Cholinesterase Inhibitionmentioning

confidence: 99%

Extractions of aerial parts of Hippomarathrum scabrum with conventional and green methodologies: Chemical profiling, antioxidant, enzyme inhibition, and anti‐cancer effects

Nilofar,

Duran,

Uba

et al. 2023

J of Separation Science

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Hippomarathrum scabrum L. is an endemic medicinal plant in Turkey; however, there have been few studies investigating the phytochemistry and biological properties of these plants has not been investigated. The aim of this work is to determine the chemical composition of different extracts (extracts obtained by using supercritical carbon dioxide extraction, accelerated solvent extraction, homogenizer‐assisted extraction, microwave‐assisted extraction, and ultrasound‐assisted extraction from Hippomarathrum scabrum L., and evaluate their biological properties. The analysis revealed that 5‐O‐caffeoylquinic acid, rutin, and isorhamnetin 3‐O‐rutinoside were the main bioactive compounds. The extract obtained by accelerated extraction contains the highest concentration of 5‐O‐Caffeoylquinic acid (7616.74 ± 63.09 mg/kg dry extract) followed by the extract obtained by homogenizer‐assisted extraction (6682.53 ± 13.04 mg/kg dry extract). In antioxidant tests, all extracts expressed significant antioxidant activity. Also, cytotoxic and anticancer effects of these plant extracts were detected in the human prostate cancer cell line. Intrinsic apoptotic genes were up‐regulated and anti‐apoptotic genes were down‐regulated in human prostate cancer cells after inhibition concentration dose treatment. The findings are promising, and suggest the use of these plant extracts could be used as natural sources with different biological activities, as well as anticancer agents.

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Kinetic modeling of chemical processes in the human brain: memory, formation of a neuroimage, and kinetic behavior of the system of synaptic contacts

Varfolomeev,

Bykov,

Tsybenova

2023

Russ Chem Bull

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Kinetic modeling of dynamic processes in the cholinergic synapse

Cited by 7 publications

References 34 publications

Kinetic model of the glutamate neuron-astrocytic system. N-acetylaspartylglutamate and glutamate carboxypeptidase

Kinetic model of the glutamate neuron-astrocytic system. N-acetylaspartylglutamate and glutamate carboxypeptidase

Extractions of aerial parts of Hippomarathrum scabrum with conventional and green methodologies: Chemical profiling, antioxidant, enzyme inhibition, and anti‐cancer effects

Kinetic modeling of chemical processes in the human brain: memory, formation of a neuroimage, and kinetic behavior of the system of synaptic contacts

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