Kinetic model of fluoride metabolism in the rabbit

Hall, Larry L.; Kilpper, R.; Smith, Frank A.; Morken, Donald A.; Hodge, Harold C.

doi:10.1016/0013-9351(77)90105-0

Cited by 17 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The experimental group was given drinking water with 100 ppm fluoride for a period of 6 months; the control group received distilled water. The fluoride dose (100 ppm) was chosen because pharmacokinetic studies by Hall et al [32] showed that it would create serum fluoride levels sufficient to cause mitogenic effects on bone cells, and higher fluoride doses cause osteosclerosis and toxic effects on growth in rabbits [30,31]. At the end of the study, the animals were anesthetized and 10 cc of blood was drawn by cardiac puncture.…”

mentioning

confidence: 99%

Fluoride Treatment Increased Serum IGF-1, Bone Turnover, and Bone Mass, but Not Bone Strength, in Rabbits

et al. 1997

View full text Add to dashboard Cite

We hypothesized that fluoride partly acts by changing the levels of circulating calcium-regulating hormones and skeletal growth factors. The effects of oral fluoride on 24 female, Dutch-Belted, young adult rabbits were studied. The rabbits were divided into two study groups, one control and the other receiving about 16 mg fluoride/rabbit/day in their drinking water. After 6 months of fluoride dosing, all rabbits were euthanized and bone and blood samples were taken for analyses. Fluoride treatment increased serum and bone fluoride levels by over an order of magnitude (P < 0.001), but did not affect body weight or the following serum biochemical variables: urea, creatinine, phosphorus, total protein, albumin, bilirubin, SGOT, or total alkaline phosphatase. No skeletal fluorosis or osteomalacia was observed histologically, nor did fluoride affect serum PTH or Vitamin D metabolites (P > 0.4). BAP was increased 37% (P < 0.05) by fluoride; serum TRAP was increased 42% (P < 0.05); serum IGF-1 was increased 40% (P < 0.05). Fluoride increased the vertebral BV/TV by 35% (P < 0.05) and tibial ash weight by 10% (P < 0.05). However, the increases in bone mass and bone formation were not reflected in improved bone strength. Fluoride decreased bone strength by about 19% in the L5 vertebra (P < 0.01) and 25% in the femoral neck (P < 0. 05). X-ray diffraction showed altered mineral crystal thickness in fluoride-treated bones (P < 0.001), and there was a negative association between crystal width and fracture stress of the femur (P < 0.02). In conclusion, fluoride's effects on bone mass and bone turnover were not mediated by PTH. IGF-1 was increased by fluoride and was associated with increased bone turnover, but was not correlated with bone formation markers. High-dose fluoride treatment did not improve, but decreased, bone strength in rabbits, even in the absence of impaired mineralization.

show abstract

mentioning

confidence: 99%

Fluoride Treatment Increased Serum IGF-1, Bone Turnover, and Bone Mass, but Not Bone Strength, in Rabbits

et al. 1997

View full text Add to dashboard Cite

show abstract

“…This contrasts with the more sophisticated linear multicompartment models constructed recently [1,3]. Actually, this simplification of fluoride metabolism modelling seems to be permissible: both short-term kinetics of 18F in man [3] as well as initial tissue distribu tion analysis after intravenous administration of 18F [14] indicate very rapid initial distribution of fluoride in almost all other tissues except bone.…”

Section: Discussionmentioning

confidence: 82%

“…We have in fact mode comparisons regarding the superiority of nonlinear over linear quantitative multicompartment resolution, and we believe such comparison to be fully possible in the case of fluoride metabolism as well. This will also enable a better-motivated attitude to be taken towards the validity of linear fluoride multicompartment models [1,3]. Quantitating mass fluxes during a wellcontrolled period of a non-steady-state situation, as occurs in hemodialysis patients, is probably also possible using a multicompartment model.…”

Section: Discussionmentioning

confidence: 99%

“…Under these circumstances, graphic rearrangement of the dif ferential equation describing fluoride concentration changes in the 'fluid' pool (measured here from serum): According to Wagner, when B is properly selected, the graph be comes a straight line which gives estimates for A, B and K if there exists a tissue-binding term in the system studied, fluoride in this instance. To test the tissue-binding character of fluoride metabolism in mammals, the data of Hall et al [1] on the fluoride kinetics in rabbit were reanalyzed with regard to a fit with the nonlinear hypothesis. Serum fluoride concentration values taken from figure 2 in the paper of Hall et al were replotted and a curve was constructed which apparently best realized the kinetic phenomena in the data ( fig.…”

Section: Calculationsmentioning

confidence: 99%

“…The use of linear multicompart ment models has been repeatedly used to analyze plasma and urine data after body loading with tracer or stable fluoride f [1][2][3] to define the short-term kinetics of fluoride. As is the case for all elements participating in bone forma tion, the long-term kinetics of fluoride are also important, and half-lives up to several years have been calculated from urine fluoride excretion data in individual cases [4].…”

mentioning

confidence: 99%

See 2 more Smart Citations

The Nonlinear Tissue-Binding Character of Fluoride Kinetics in Normal and Anephric Subjects

Kekki¹,

Lampainen²,

Kauranen³

et al. 1982

Nephron

View full text Add to dashboard Cite

A study has been made of the fluoride kinetics in man, with a series of 5 healthy subjects and 4 patients with renal insufficiency. The fluoride metabolism was found to conform to nonlinear tissue-binding kinetics. Reanalysis of findings on the rabbit reported in the literature yielded equivalent results. The tissue-binding constants elicited -probably associated with the fluoride metabolism of bone – presented no differences between healthy subjects and uremics. Uremics had a clearly lower fractional fluoride elimination rate (K) compared with the healthy controls. A significant correlation of creatinine clearance on the K value was noted.

show abstract

Fluoride accumulation and toxicity in laboratory populations of wild small mammals and white mice

Boulton

Cooke

Johnson

1995

J of Applied Toxicology

View full text Add to dashboard Cite

A laboratory experiment was conducted to compare the toxicological response and metabolism of inorganic fluoride by three species of wild mammals and laboratory white mice (Mus musculus L.). The experimental populations of the wild species--the short-tailed field vole (Microtus agrestis L.), the bank vole (Clethrionomys glareolus L.) and the the wood mouse (Apodemus sylvaticus L.)--were laboratory reared from wild stock, and all test animals were exposed to 0, 40 or 80 microgram F per ml in their drinking water for up to 84 days. The 40 and 80 microgram F per ml treatments induced premature mortalities in M. agrestis and C. glareolus only. Differential intakes, absorption and retention of fluoride were evident between M. musculus and M. agrestis, the two species subject to cage studies of fluoride metabolism budgets. Interspecific variation in accumulation of fluoride with time was also evident between all four species as regards the femur, molars and incisors. Severe dental lesions were apparent in species surviving the 80 microgram ml(-1) treatment for 84 days. Overall, however, there were few clear differences in inherent species sensitivity to fluoride, the interspecific variation in metabolism and accumulation rates being attributable mainly to variation in intake.

show abstract

Kinetic model of fluoride metabolism in the rabbit

Cited by 17 publications

References 6 publications

Fluoride Treatment Increased Serum IGF-1, Bone Turnover, and Bone Mass, but Not Bone Strength, in Rabbits

Fluoride Treatment Increased Serum IGF-1, Bone Turnover, and Bone Mass, but Not Bone Strength, in Rabbits

The Nonlinear Tissue-Binding Character of Fluoride Kinetics in Normal and Anephric Subjects

Fluoride accumulation and toxicity in laboratory populations of wild small mammals and white mice

Contact Info

Product

Resources

About