Kinetic metrics of 18F-FDG in normal human organs identified by systematic dynamic total-body positron emission tomography

Liu, Guobing; Xu, Hongtao; Hu, Pengcheng; Tan, Hui; Zhang, Yiqiu; Yu, Haojun; Li, Xuening; Shi, Hongcheng

doi:10.1007/s00259-020-05124-y

Cited by 32 publications

(22 citation statements)

References 20 publications

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“…Compared with the static SUV FDG images, the suppression of blood pool is obvious in MR FDG images for organs that have non-negligible fraction of blood pool compartment, such as the liver, spleen, large vessels, and renal pelvises. This feature of MR FDG images commonly results in higher contrast for lesions located close to these anatomical structures as reported in previous studies ( 21 , 25 ). Due to the long scanning time, the only drawback of MR FDG image and DV FDG image was the deviation caused by intestinal peristalsis artifacts, which affected the diagnosis of intestinal lesions, which is consistent with the previous research ( 26 ).…”

Section: Discussionsupporting

confidence: 78%

Improved Clinical Workflow for Whole-Body Patlak Parametric Imaging Using Two Short Dynamic Acquisitions

Wang

Miao

et al. 2022

Front. Oncol.

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ObjectiveWe sought to explore the feasibility of shorter acquisition times using two short dynamic scans for a multiparametric PET study and the influence of quantitative performance in shortened dynamic PET.MethodsTwenty-one patients underwent whole-body dynamic 18F-FDG PET/CT examinations on a PET/CT (Siemens Biograph Vision) with a total scan time of 75 min using continuous bed motion for Patlak multiparametric imaging. Two sets of Patlak multiparametric images were produced: the standard MRFDG and DVFDG images (MRFDG-std and DVFDG-std) and two short dynamic MRFDG and DVFDG images (MRFDG-tsd and DVFDG-tsd), which were generated by a 0–75 min post injection (p.i.) dynamic PET series and a 0–6 min + 60–75 min p.i. dynamic PET series, respectively. The maximum, mean, and peak values of the standard and two short dynamic multiparametric acquisitions were obtained and compared using Passing–Bablok regression and Bland–Altman analysis.ResultsHigh correlations were obtained between MRFDG-tsd and MRFDG-std, and between DVFDG-tsd and DVFDG-std for both normal organs and all lesions (0.962 ≦ Spearman’s rho ≦ 0.982, p < 0.0001). The maximum, mean, and peak values of the standard and two short dynamic multiparametric acquisitions were also in agreement. For normal organs, the Bland–Altman plot showed that the mean bias of MRFDG-max, MRFDG-mean, and MRFDG-peak was -0.002 (95% CI: -0.032–0.027), -0.002 (95% CI: -0.026–0.023), and -0.002 (95% CI: -0.026–0.022), respectively. The mean bias of DVFDG-max, DVFDG-mean, and DVFDG-peak was -3.3 (95% CI: -24.8–18.2), -1.4 (95% CI: -12.1–9.2), and -2.3 (95% CI: -15–10.4), respectively. For lesions, the Bland–Altman plot showed that the mean bias of MRFDG-max, MRFDG-mean, and MRFDG-peak was -0.009 (95% CI: -0.056–0.038), -0.004 (95% CI: -0.039–0.031), and -0.004 (95% CI: -0.036–0.028), respectively. The mean bias of DVFDG-max, DVFDG-mean, and DVFDG-peak was -8.4 (95% CI: -42.6–25.9), -4.8 (95% CI: -20.2–10.6), and -4.0 (95% CI: -23.7–15.6), respectively.ConclusionsThis study demonstrates the feasibility of using two short dynamic scans that include the first 0–6 min and 60–75 min scans p.i. for Patlak multiparametric images, which can increase patient throughout for parametric analysis.

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Section: Discussionsupporting

confidence: 78%

Improved Clinical Workflow for Whole-Body Patlak Parametric Imaging Using Two Short Dynamic Acquisitions

Wang

Miao

et al. 2022

Front. Oncol.

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“…Total-body PET detector crystals with a size of 2.76×2.76×18.0 mm 3 coupled to silicon photomultipliers (SIPMs) shows ultrahigh sensitivity and spatial resolution [5]. Recently, a series of studies report that low injection activity of 18 F-FDG or a shorter scan time of total-body PET/CT imaging may be feasible for good image quality [6][7][8][9]. Increasing injection activity and prolonging acquisition time might improve image quality to some extent, though the probability of radiation-related injury and later-occurring effects as well as the possibility of moving artifacts inevitably increase [10].…”

Section: Introductionmentioning

confidence: 99%

A personal acquisition time regimen of 68Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): A feasibility study.

Xiao

Sui

et al. 2022

Preprint

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Purpose: To propose a personal acquisition time regimen of 68Ga-DOTATATE total-body positron emission tomography-computed tomography (PET/CT) for acceptable and constant image quality of patients with neuroendocrine tumors (NETs).Methods: A development cohort consisting of 19 consecutive patients with full activity (88.7-204.9 MBq/kg) was used to establish the acquisition time regimen. The liver SNR (signal-to-noise ratio, SNRL) was normalized (SNRnorm) by the product of injected activity and acquisition time. Fitting of SNRnorm against body mass (BM) in linear correlation was performed. Subjective assessment of image quality was performed using a 5-point Likert scale to determine the acceptable threshold of SNRL, and an optimized acquisition regimen based on BM was proposed and validated using a cohort of 57 NET patients with half activity (66.9±11.3 MBq, 1.0±0.1 MBq/kg) in a fixed acquisition time regimen.Results: The linear correlation (R2=0.63) between SNRnorm and BM was SNRnorm=-0.01*BM+1.50. The threshold SNRL of acceptable image quality was 11.2. The patient-specific variable acquisition time regimen was then determined as t (min) = 125.4/(injective activity)*(-0.01*BM+1.50)2. Based on the regimen, the average acquisition time for acceptable image quality in the validation cohort was 2.99±0.91 min, ranging from 2.18 to 6.35 min, which was reduced by 36.50%~78.20% compared with the fixed acquisition time of 10 min. Subjective evaluation showed that acceptable image quality could be obtained at 3.00 min in the low-activity group, with an average score of 3.44±0.53 (kappa = 0.97, 95% CI: 0.96~0.98). Bland–Altman analysis revealed good agreement between the proposed regimen and the fixed acquisition time cohort.Conclusion: A personal acquisition time regimen was proposed and validated for NET patients for 68Ga-DOTATATE total-body PET/CT imaging. Based on the regimen, the image quality is feasible for a constant level, independent of body mass, with reasonable acquisition time.

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“…Dynamic position emission tomography (dPET) with 18F-uorodeoxyglucose (18F-FDG) is a powerful imaging tool to noninvasively collect glucose metabolic information and pharmaceutical kinetic parameters in-vivo [1]. Different from the static PET which provides a semi-quantitative index (SUV) at a certain time point post injection [2,3], dPET quantitates the kinetic parameters of glucose metabolism in combination with pharmacokinetic models [4,5]. Previous studies have demonstrated the superiority of dPET imaging in differential diagnosis, tumour staging and the evaluation of treatment response in oncology [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Despite that whole-body dPET collected with either continuous bed motion or step-and-shoot multi-bed position provides a key measure to perform the precise diagnosis at locoregional area [16][17][18][19], the synchronized acquisition of temporal and spatial information is under expectation. With the advent of the total-body PET/CT scanner with a 194-cm long AFOV (uEXPLORER, United Imaging Healthcare, China), it is possible to collect both pathological and physiological information for the entire human body in one bed position [4,[20][21][22]. Additionally, the high PET sensitivity of the total-body scanner allows to generate time-activity curves (TACs) with ne structure.…”

Section: Introductionmentioning

confidence: 99%

Is Dynamic Total-body PET Imaging Feasible in the Clinical Daily Practice?

Chen

et al. 2021

Preprint

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PurposeDynamic PET (dPET) imaging of multi-temporal frames can quantitate tracer kinetics and has been mostly used in the research rather than clinical daily practice due to the long acquisition time. The total-body PET/CT scanner can generate fine time-activity curves (TACs) in dPET imaging and provide tempo-spatially synchronized pharmacokinetics in the entire human body. To investigate the feasibility in daily practice, the study aimed to explore the shortest acquisition time of dPET imaging. MethodsTen patients who underwent an 18F-FDG total-body dPET examination were retrospectively enrolled. Both the Patlak graphic analysis (Ki) and irreversible two tissues compartment model (i2TCM) analysis (K1, k2, k3) were used to calculate the kinetic parameters with different shortened acquisition durations. These kinetic parameters at various organs/tissues and lesions were compared with those obtained from the reference 60min acquisition. In addition, a hybrid approach combining the initial 20-min dPET data and the static PET scan at 55-60 min post-injection was proposed, and the kinetic parameters were calculated and compared with the references. ResultsPatlak Ki derived from the first 50-min dPET acquisition showed no significant difference in healthy organs/tissues compared with the reference (all p > 0.05), while the lesions can be visually distinguished even in the initial 20-min Ki images. In the i2TCM analysis, the kinetic parameters — K1, k2, k3 of 30-min dPET acquisition showed no significant difference for healthy organs/tissues and lesions compared to 60-min dPET acquisition (all p > 0.05). The kinetic parameters obtained from the proposed hybrid approach can provide reliable kinetic parameters as well as those obtained in the static PET imaging. ConclusionsThe dPET total-body imaging can be shortened to 30 min to generate reliable kinetic parameters with i2TCM. Additionally, the hybrid approach provides both robust tracer metabolic information and the conventional standard uptake values (SUVs), demonstrating its feasibility in clinical practice.

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Kinetic metrics of 18F-FDG in normal human organs identified by systematic dynamic total-body positron emission tomography

Cited by 32 publications

References 20 publications

Improved Clinical Workflow for Whole-Body Patlak Parametric Imaging Using Two Short Dynamic Acquisitions

Improved Clinical Workflow for Whole-Body Patlak Parametric Imaging Using Two Short Dynamic Acquisitions

A personal acquisition time regimen of 68Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): A feasibility study.

Is Dynamic Total-body PET Imaging Feasible in the Clinical Daily Practice?

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