Abstract:Background-The dopamine D2 receptor (D2R) is a therapeutic target for the treatment of several neuropsychiatric disorders. The D2R can couple to all members of the heterotrimeric Galpha-i/o/z protein family but the physiological importance of coupling to distinct G protein subtypes remains unclear. It has been demonstrated that slow-dissociating agonists display time-dependent biased agonism between endpoints at different levels in the D2R signalling cascade(1). The aim of this study was to explore biased agon… Show more
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