“…Bergström, Carlson & Weeks (1968) and Butcher & Baird (1968) have proposed the concept that prostaglandins may feed back to regulate the adenyl cyclase system. There is evidence for such a mechanism in a variety of tissues (Kuehl, Humes, Tarnoff, Cirillo & Ham, 1970;Sato, Szabo, Kowalski & Burke, 1972;Kantor, Tao & Kiefer, 1974). Kantor et al (1974) identified the presence of two independent prosta¬ glandin receptors on, or associated with, the adenyl cyclase.…”