Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains
Sherry Wong,
Madeline E. West,
Gareth J. Morgan
Abstract:Aggregation of antibody light chain proteins is associated with the progressive disease light chain amyloidosis. Patient‐derived amyloid fibrils are formed from light chain variable domain residues in non‐native conformations, highlighting a requirement that light chains unfold from their native structures in order to aggregate. However, mechanistic studies of amyloid formation have primarily focused on the self‐assembly of natively unstructured peptides, and the role of native state unfolding is less well und… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.