Kinetic characterization of ecto-nucleoside triphosphate diphosphohydrolases in brain nerve terminals during rat postnatal development

Stanojević, Ivana M.; Drakulić, Dunja; Petrović, Snježana; Milošević, Maja; Jovanović, Nina; Horvat, Anica

doi:10.1134/s0036024411130292

Cited by 1 publication

(1 citation statement)

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“…There is widespread mRNA expression for ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different rat brain regions during development and ageing [316]. There was an increase in both ATP and ADP hydrolysis by ecto-NTPDases 1-3 in synaptic plasma membranes isolated from rats in the first and second months of life and then decreased in adult life [317].…”

Section: Stem Cellsmentioning

confidence: 98%

Purinergic signalling during development and ageing

Burnstock

Dale

2015

Purinergic Signalling

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Extracellular purines and pyrimidines play major roles during embryogenesis, organogenesis, postnatal development and ageing in vertebrates, including humans. Pluripotent stem cells can differentiate into three primary germ layers of the embryo but may also be involved in plasticity and repair of the adult brain. These cells express the molecular components necessary for purinergic signalling, and their developmental fates can be manipulated via this signalling pathway. Functional P1, P2Y and P2X receptor subtypes and ectonucleotidases are involved in the development of different organ systems, including heart, blood vessels, skeletal muscle, urinary bladder, central and peripheral neurons, retina, inner ear, gut, lung and vas deferens. The importance of purinergic signalling in the ageing process is suggested by changes in expression of A1 and A2 receptors in old rat brains and reduction of P2X receptor expression in ageing mouse brain. By contrast, in the periphery, increases in expression of P2X3 and P2X4 receptors are seen in bladder and pancreas.

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Section: Stem Cellsmentioning

confidence: 98%