, VA. Mr Franz is now at the University of Colorado at Boulder, Boulder, CO.Context: Knowledge of the kinetic changes that occur during sloped running is important in understanding the adaptive gaitcontrol mechanisms at work and can provide additional information about the poorly understood relationship between injury and changes in kinetic forces in the lower extremity. A study of these potential kinetic changes merits consideration, because training and return-to-activity programs are potentially modifiable factors for tissue stress and injury risk.Objective: To contribute further to the understanding of hill running by quantifying the 3-dimensional alterations in joint kinetics during moderately sloped decline, level, and incline running in a group of healthy runners.Design: Crossover study. Setting: Three-dimensional motion analysis laboratory.Patients or Other Participants: Nineteen healthy young runners/joggers (age 5 25.3 6 2.5 years).Intervention(s): Participants ran at 3.13 m/s on a treadmill under the following 3 different running-surface slope conditions: 46 decline, level, and 46 incline.Main Outcome Measure(s): Lower extremity joint moments and powers and the 3 components of the ground reaction force.Results: Moderate changes in running-surface slope had a minimal effect on ankle, knee, and hip joint kinetics when velocity was held constant. Only changes in knee power absorption (increased with decline-slope running) and hip power (increased generation on incline-slope running and increased absorption on decline-slope running in early stance) were noted. We observed an increase only in the impact peak of the vertical ground reaction force component during decline-slope running, whereas the nonvertical components displayed no differences.Conclusions: Running style modifications associated with running on moderate slopes did not manifest as changes in 3-dimensional joint moments or in the active peaks of the ground reaction force. Our data indicate that running on level and moderately inclined slopes appears to be a safe component of training regimens and return-to-run protocols after injury.Key Words: biomechanics, decline running, incline running, joint moments, joint power Key Points N Running style modifications on moderate slopes did not manifest as changes in 3-dimensional joint moments or active peaks of the ground reaction force. N However, changes in knee power absorption (increased on the decline slope) and hip power (increased generation on the incline slope and increased absorption on the decline slope in early stance) were seen. The impact peak of the vertical ground reaction force increased only during running on the decline slope.N Running on level and moderately inclined slopes appears to be a safe component of training regimens and return-to-run protocols after injury.