Kinetic approach for the enzymatic determination of levodopa and carbidopa assisted by multivariate curve resolution-alternating least squares

Flow-Based Systems for Rapid and High-Precision Enzyme Kinetics Studies

“…The complex data obtained from different kinetic studies may be better evaluated with the help of statistics, chemometrics, and computational modeling. These tools can help to save time and offer better prediction and conclusion about performance and characteristics of enzymes [90] as well as quantitative analysis of enzyme [91]. …”

Evaluation of conversion during the synthesis of aluminum (III) methacrylate-based copolymers using Raman spectroscopy and multivariate curve resolution

“…MCR-ALS is extensively employed in several technological issues related with the quantitation antibacterial agents presented water samples [44], determination of furosemide in the presence of interfering agent (anti-inflammatory flufenamic acid) [45], quantitative determination of sulfur [32], sulfonamide drugs in biomedical analysis [46], mixtures of nitrophenols pollutants in environmental and biological samples [34], proteinaceous binders in medieval paints [37], antioxidants (butylatedhydroxytoluene and N,N′-di-secbutyl-p-phenylenediamine) in biodiesel blends [41] and concentration profiles in milk lactic acid fermentation [33]; enzymatic determination of levodopa and carbidopa in pharmaceuticals [47], measurements of the relative amounts of different iron oxide and oxyhydroxides present in the passive films [48], interpretation of the kinetic behavior of the photochemical degradation process of decabromodiphenyl ether [43] and photodynamics of salicylidene aniline in ultrafast competitive photoreactions [38].…”

Novel contribution to the simultaneous monitoring of pramipexole dihydrochloride monohydrate and levodopa as co-administered drugs in human plasma utilizing UPLC–MS/MS

“…2 Long-term treatment with LVD is frequently accompanied with development of various types of undesired motor complications after nearly 2 years, so other classes of antiparkinsonism drugs such as dopamine agonists (e.g., PDM), catechol-O-methyl transferase inhibitors, or monoamine oxidase type B inhibitors should be used as adjuvant therapy. 2,[25][26][27][28] Literature survey has revealed several methods for the quantification of LVD such as, 1 H nuclear magnetic resonance, 29 spectrophotometry, 30 fluorimetry, 31 chemometry, 32,33 HPLC, 34,35 TLC, 36 electrochemistry, 37,38 LC-MS/MS, [39][40][41][42] and CE. 43 Combination treatment of LVD with PDM was used for the treatment of Parkinson's disease.…”