Kinetic and Equilibrium Studies of Doxorubicin Adsorption onto Carbon Nanotubes

Chudoba, Dorota; Łudzik, Katarzyna; Jażdżewska, Monika; Woloszczuk, Sebastian

doi:10.3390/ijms21218230

Cited by 26 publications

(18 citation statements)

References 69 publications

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“…The broad pH regions with a decrease of ζ-potentials at the increasing pH are characteristic for nanodiamonds, 74,75 while the exact match of ζ-potential decrease areas to the observed ones can be found only in some of the oxidized CNPs. 76,77 The pH range studied here can be divided into distinct regions as follows.…”

Section: Resultsmentioning

confidence: 99%

Surface Photoluminescence of Oxidized Nanodiamonds: Influence of Environment pH

et al. 2021

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Nanoparticles’ environment, in particular pH, can strongly affect their photoluminescence (PL). This can be especially true for the surface PL of nanodiamonds (NDs) known to be dependent on the composition of surface groups. In this paper, the effect of environmental pH in the range from 2 to 12.5 on the surface photoluminescence of oxidized NDs of various syntheses and surface treatments was investigated. For the first time, the varying changes of the NDs’ PL with the pH were shown, having, however, an essential common feature: they were observed in the same pH regions from 2 to 5 and from 9 to 12.5, while in the pH region from 5 to 9, the PL intensity of all samples was almost constant. Obtained dependences of NDs’ ζ-potentials on pH and quantum mechanical modeling showed that all changes of NDs’ PL are due to the (de)protonation of surface groups: carboxyl at pH from 2 to 5 and hydroxyl on sp2-hybridized carbon at pH from 9 to 12.5. The varying response of NDs’ PL to such deprotonation shows the possibility of tuning the surface photoluminescence of NDs for use in industry and biomedicine beyond what is possible by only controlling the nanodiamonds’ surface groups.

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Section: Resultsmentioning

confidence: 99%

Surface Photoluminescence of Oxidized Nanodiamonds: Influence of Environment pH

et al. 2021

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“…where R (8.314 J/mol K) is the ideal gas constant, T (K) is the temperature, C ad, e is the concentration of nitrate or nitrite on M-CHT at equilibrium (mg-N/L) and K c ' is the apparent equilibrium constant. The value of K c ' in the lowest experimental nitrate or nitrite concentration can be obtained (Chudoba 2020). It is known that adsorption reaction is a spontaneous process when ΔG°are negative values (Shahwan 2021).…”

Section: Equilibrium Studymentioning

confidence: 96%

Adsorption of nitrate and nitrite from aqueous solution by magnetic Mg/Fe hydrotalcite

Chen

Wei

et al. 2021

Water Supply

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In this study, magnetic Mg/Fe hydrotalcite calcined material (M-CHT) was synthesized through co-precipitation and calcination method, and was used to effectively remove nitrate and nitrite from water. M-CHT can restore its original layered structure after the adsorption of nitrate or nitrite, and can be easily separated by the applied magnetic field. The first-order and pseudo-second-order kinetic models (R2 ≥ 0.97) can better describe the adsorption kinetic process. The equilibrium isotherm showed that the Langmuir model provided a better fit to the experimental data than the Freundlich model for nitrates and nitrites. With temperature increased from 298 to 308 K, the maximum adsorption capacity obtained by the Langmuir model increased from 10.60 to 16.90 mg-N/g for nitrate and 7.89 to 14.28 mg-N/g for nitrite, respectively. The adverse effect of coexisting anions ranked in the order of ClO4− > Cl− > SO42− > F− > CO32− > PO43−. The actual Fe2+/Fe3+ value of M-CHT (0.56) is nearly consistent with the theoretical value of 0.5, and the saturation magnetic strength value of M-CHT is 9.15 emu/g, greatly contributing to the solid-liquid separation. Overall, M-CHT with features of magnetic properties and satisfactory adsorption capacity exhibits the greatly promising for application in wastewater purification.

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“…3800 mg/g, while in the case of p MWCNTs, it was ca. 175 mg/g [ 28 ]. The adsorption process of DOX onto MWCNTs was performed by means of a buffer of neutral pH (about 7.4).…”

Section: Resultsmentioning

confidence: 99%

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

Chudoba

Jażdżewska

Łudzik

et al. 2021

IJMS

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The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drugs. The surface of carbon nanotubes (CNTs) has been modified via treatment in nitric acid to optimize the adsorption and release process. The modification efficiency and physicochemical properties of the MWCNTs+DOX system were analyzed by using SEM, TEM, EDS, FTIR, Raman Spectroscopy and UV-Vis methods. Based on computer simulations at pH 7.4 and the experiment at pH 5.4, the kinetics and the mechanism of DOX release from MWNT were discussed. It has been experimentally observed that the acidic pH (5.4) is appropriate for the efficient release of the drug from CNTs. It was noted that under acidic pH conditions, which is typical for the tumour microenvironment almost 90% of the drug was released in a relatively short time. The kinetics models based on different mathematical functions were used to describe the release mechanism of drugs from MWCNTs. Our studies indicated that the best fit of experimental kinetic curves of release has been observed for the Power-law model and the fitted parameters suggest that the drug release mechanism of DOX from MWCNTs is controlled by Fickian diffusion. Molecular dynamics simulations, on the other hand, have shown that in a neutral pH solution, which is close to the blood pH, the release process does not occur keeping the aggregation level constant. The presented studies have shown that MWCNTs are promising carriers of anticancer drugs that, depending on the surface modification, can exhibit different adsorption mechanisms and release.

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Kinetic and Equilibrium Studies of Doxorubicin Adsorption onto Carbon Nanotubes

Cited by 26 publications

References 69 publications

Surface Photoluminescence of Oxidized Nanodiamonds: Influence of Environment pH

Surface Photoluminescence of Oxidized Nanodiamonds: Influence of Environment pH

Adsorption of nitrate and nitrite from aqueous solution by magnetic Mg/Fe hydrotalcite

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

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