Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non‐small cell lung cancer patients

Abstract

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractBackground: This present study was to explore the association of kinesin family member 2A (KIF2A) expression with clinicopathological features and survival profiles, and the effect of KIF2A on cell proliferation and chemosensitivity in non-small cell lung cancer (NSCLC). Methods:Tumor and paired adjacent specimens were collected from 380 patients with NSCLC underwent resection for immunohistochemistry assay of KIF2A expression. In vitro, the effect of KIF2A on cell proliferation, chemosensitivity to cisplatin/ vinorelbine was detected via KIF2A plasmids transfection into NCI-H1299 NSCLC cells.Results: Kinesin family member 2A expression was upregulated in tumor tissues compared with adjacent tissues, and tumor tissue KIF2A high expression was associated with higher pathological grade (P < .001), larger tumor size (P = .021), lymph node metastasis (P = .044), and increased tumor-node-metastasis stage (P = .001).As for survival profiles, disease-free survival (P < .001) and overall survival (P < .001) were worse in patients with KIF2A high expression compared with those with KIF2A low expression. Multivariate Cox's regression exhibited that KIF2A high expression was an independent predictive factor for lower DFS (P < .001) and OS (P < .001). In vitro, KIF2A promoted proliferation and decreased chemosensitivity to cisplatin but not vinorelbine in NCI-H1299 NSCLC cells. Conclusions:The correlation of KIF2A expression with tumor features, survival, and its cellular function implies its potential as a prognostic biomarker and a treatment target in NSCLC. K E Y W O R D Scell proliferation, chemosensitivity, clinical features, kinesin family member 2A, non-small cell lung cancer

Circular RNA circ_0010235 sponges miR-338-3p to play oncogenic role in proliferation, migration and invasion of non-small-cell lung cancer cells through modulating KIF2A

“…Functionally, restoring KIF2A was conductive to NSCLC cell malignancies, and oncogenic role of KIF2A had been demonstrated in LUSC and LUAD [18,19,32]. Furthermore, hyperexpression of KIF2A was previously uncovered to be closely correlated with higher stage and lymph node metastasis in NSCLC patients, as well as worse overall survival and disease-free survival [18,19,32]. Chemoresistance to cisplatin in NSCLC seemed also acquired with KIF2A overexpression [32].…”

“…Additionally, in NSCLC biopsies, KIF2A mRNA expression was linear and negatively correlated with miR-338-3p but positively correlated with circ_0010235. Functionally, restoring KIF2A was conductive to NSCLC cell malignancies, and oncogenic role of KIF2A had been demonstrated in LUSC and LUAD [ 18 , 19 , 32 ]. Furthermore, hyperexpression of KIF2A was previously uncovered to be closely correlated with higher stage and lymph node metastasis in NSCLC patients, as well as worse overall survival and disease-free survival [ 18 , 19 , 32 ].…”

“…Furthermore, hyperexpression of KIF2A was previously uncovered to be closely correlated with higher stage and lymph node metastasis in NSCLC patients, as well as worse overall survival and disease-free survival [ 18 , 19 , 32 ]. Chemoresistance to cisplatin in NSCLC seemed also acquired with KIF2A overexpression [ 32 ]. By the way, similar to KIF2A, KIF2C was also a computational target for miR-338-3p according to StarBase software.…”

Clinical Significance of Polo-Like Kinase 4 as a Marker for Advanced Tumor Stage and Dismal Prognosis in Patients With Surgical Gastric Cancer

“…The IHC score ≤3 was defined as PLK4 low expression, and the IHC score >3 was defined as PLK4 high expression. 13 , 14 …”

“…The IHC score 3 was defined as PLK4 low expression, and the IHC score >3 was defined as PLK4 high expression. 13,14 Statistical Analysis 22.0 (IBM), and all figures were plotted using GraphPad Prism version 7.00 (GraphPad Software). P value <.05 was considered as significant.…”