Kinematic
            <scp>A</scp>
            daptive
            <scp>D</scp>
            eep
            <scp>B</scp>
            rain
            <scp>S</scp>
            timulation for
            <scp>R</scp>
            esting
            <scp>T</scp>
            remor in
            <scp>P</scp>
            arkinson's
            <scp>D</scp>
            isease

Malekmohammadi, Mahsa; Herron, Jeffrey A.; Velisar, Anca; Blumenfeld, Zack; Trager, Megan H.; Chizeck, H.J.; Brontë‐Stewart, Helen

doi:10.1002/mds.26482

Cited by 114 publications

(99 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Activa PC+S can also be used to prototype feedback-controlled DBS algorithms, guided either by brain recording, or external sensors 15 . Feedback control may improve DBS therapy by real time-adjustment of stimulation parameters in response to fluctuating signs and symptoms 14,28 .…”

Section: Discussionmentioning

confidence: 99%

“…This device, Activa PC+S ( Medtronic, Inc ), allows chronic, intermittent collection of field potential data over years, initiated either by investigators in the clinic, by patients in their homes, or by automated algorithms 1,2,30,32,33 . The device is available to research groups worldwide under investigator-initiated protocols, or under CE Mark in European countries 15,20,27 . In our study, the stimulation/sensing pulse generator is attached to both a basal ganglia and a cortical electrode array, to allow multisite recordings for network-level analyses.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic multisite brain recordings from a totally implantable bidirectional neural interface: experience in 5 patients with Parkinson's disease

Swann¹,

Hemptinne²,

Miocinovic

et al. 2018

Journal of Neurosurgery

114

123

View full text Add to dashboard Cite

OBJECTIVE Dysfunction of distributed neural networks underlies many brain disorders. Development of neuromodulation therapies depends on a better understanding of these networks. Invasive human brain recordings have a favorable temporal and spatial resolution for the analysis of network phenomena, but have generally been limited to acute intraoperative recording or short term recording through temporarily externalized leads. Here we describe our initial experience with an investigational, totally implantable, first generation, bidirectional neural interface that allows for both continuous therapeutic stimulation and recordings of field potentials at multiple sites in a neural network. METHODS We implanted five Parkinson’s disease patients with Activa PC+S (Medtronic Inc.), under a physician-sponsored Food and Drug Administration investigational device exemption. The device was attached to a quadripolar lead placed in the subdural space over motor cortex, for recording of electrocorticography (ECoG) potentials, and to a quadripolar lead in subthalamic nucleus (STN) for both therapeutic stimulation and recording of local field potentials (LFPs). We recorded from each patient at multiple time points over a one year period. RESULTS There were no serious surgical complications or interruptions of DBS therapy. Signals in both cortex and STN were relatively stable over time, despite a gradual increase in electrode impedance. We were able to identify canonical movement related changes in specific frequency bands in motor cortex in most but not all recordings. CONCLUSION Acquisition of chronic multisite field potentials in humans is feasible. Device performance characteristics described here may inform the design of the next generation of totally implantable neural interfaces. This research tool provides a platform for translation of discoveries in brain network dynamics to improved neurostimulation paradigms.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic multisite brain recordings from a totally implantable bidirectional neural interface: experience in 5 patients with Parkinson's disease

Swann¹,

Hemptinne²,

Miocinovic

et al. 2018

Journal of Neurosurgery

114

123

View full text Add to dashboard Cite

show abstract

“…However, the activity-dependent fluctuations in the beta-band power limit its use a sole control for closed loop DBS in PD tremor. Bronte-Stewart and colleagues (Malekmohammadi et al, 2016) reported the efficacy of closed loop STN DBS to control resting tremor, using a kinematic measure of tremor power from use of a wearable Bluetooth enabled smart watch (LG G-watch; Figure 5). …”

Section: Closed-loop Dbsmentioning

confidence: 99%

Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies

Deeb

Giordano

Rossi

et al. 2016

Front. Integr. Neurosci.

View full text Add to dashboard Cite

This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome. Next, advances in the use of neuroimaging and electrochemical markers to enhance DBS specificity were addressed. Updates on ongoing use and developments of DBS for the treatment of Parkinson's disease, essential tremor, Alzheimer's disease, depression, post-traumatic stress disorder, obesity, addiction were presented, and progress toward innovation(s) in closed-loop applications were discussed. Each section of these proceedings provides updates and highlights of new information as presented at this year's international Think Tank, with a view toward current and near future advancement of the field.

show abstract

“…Case studies in Parkinson’s disease [37] and essential tremor [38] suggest the feasibility of using wearable sensors. One downside of this approach is that the system will only be able to suppress symptoms after they manifest, and neural signals would be likely to neuromodulate prior to a clinical manifestation.…”

Section: Development Of Closed-loop Dbs Systemsmentioning

confidence: 99%

Reengineering deep brain stimulation for movement disorders: Emerging technologies

Gündüz

Foote

Okun

2017

Current Opinion in Biomedical Engineering

View full text Add to dashboard Cite

Deep brain stimulation (DBS) is a neurosurgical technique, which consists of continuous delivery of an electrical pulse through chronically implanted electrodes connected to a neurostimulator, programmable in amplitude, pulse width, frequency, and stimulation channel. DBS is a promising treatment option for addressing severe and drug-resistant movement disorders. The success of DBS therapy is a combination of surgical implantation techniques, device technology, and clinical programming strategies. Changes in device settings require highly trained and experienced clinicians to achieve maximal therapeutic benefit for each targeted symptom, and optimization of stimulation parameters can take many visits. Thus, the development of innovative DBS technologies that can optimize the clinical implementation of DBS will lead to wider scale utilization. This review aims to present engineering approaches that have the potential to improve clinical outcomes of DBS, focusing on the development novel temporal patterns, innovative electrode designs, computational models to guide stimulation, closed-loop DBS, and remote programming.

show abstract

Kinematic A daptive D eep B rain S timulation for R esting T remor in P arkinson's D isease

Cited by 114 publications

References 8 publications

Chronic multisite brain recordings from a totally implantable bidirectional neural interface: experience in 5 patients with Parkinson's disease

Chronic multisite brain recordings from a totally implantable bidirectional neural interface: experience in 5 patients with Parkinson's disease

Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies

Reengineering deep brain stimulation for movement disorders: Emerging technologies

Contact Info

Product

Resources

About