Abstract:The principles of kinematic manufacturing machines of the type widely used since the industrial revolution are reviewed. Consideration is then given to how the principles of kinematics ('the geometry of motion') may manifest in molecular catalysts. Actions of this type involve synchronized, regular, repeated and rapid conformational flexing along geometrically optimum pathways that define a single degree of freedom. The proposition that many of the catalysts of biology, enzymes, may generally exploit a kinemat… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.