Kindling-induced changes in morphine analgesia and catalepsy: Evidence for independent opioid systems

Yitzhaky, Jacob; Frenk, Hanan; Urca, Gideon

doi:10.1016/0006-8993(82)90567-4

Cited by 12 publications

(1 citation statement)

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“…Despite several reports suggesting that both electrically and chemically induced post-ictal immobility syndrome Mares and Rokyta, 2009;Myslobodsky et al, 1981) can be followed by opioid (Urca et al, 1981;Yitzhaky et al, 1982) and non-opioid de Oliveira et al, 2006) antinociception, serotonergic neurotransmission in post-ictal antinociception, recruiting the endogenous pain inhibitory system was first demonstrated within the last decade (Coimbra et al, 2001a;de Oliveira et al, 2006).…”

Section: Synapsementioning

confidence: 98%

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT_2Aand 5-HT_2Cserotonergic receptors in post-ictal antinociception

Freitas

Oliveira

et al. 2013

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The periaqueductal gray matter (PAG) consists in a brainstem structure rich in 5-hydroxytryptamine (5-HT) inputs related to the modulation of pain. The involvement of each of the serotonergic receptor subtypes found in PAG columns, such as the dorsomedial (dmPAG) and the ventrolateral (vlPAG) columns, regarding post-ictal antinociception have not been elucidated. The present work investigated the participation of the dmPAG and vlPAG columns in seizure-induced antinociception. Specifically, we studied the involvement of serotonergic neurotransmission in these columns on antinociceptive responses that follow tonic-clonic epileptic reactions induced by pentylenetetrazole (PTZ), an ionophore GABA-mediated Cl(-) influx antagonist. Microinjections of cobalt chloride (1.0 mM CoCl2 /0.2 µL) into the dmPAG and vlPAG caused an intermittent local synaptic inhibition and decreased post-ictal antinociception that had been recorded at various time points after seizures. Pretreatments of the dmPAG or the vlPAG columns with the nonselective serotonergic receptors antagonist methysergide (5.0 µg/0.2 µL) or intramesencephalic microinjections of ketanserin (5.0 µg/0.2 µL), a serotonergic antagonist with more affinity to 5-HT2A/2C receptors, decreased tonic-clonic seizure-induced antinociception. Both dmPAG and vlPAG treatment with either the 5-HT2A receptor selective antagonist R-96544 (10 nM/0.2 µL), or the 5-HT2C receptors selective antagonist RS-102221 (0.15 µg/0.2 µL) also decrease post-ictal antinociception. These findings suggest that serotonergic neurotransmission, which recruits both 5-HT2A and 5-HT2C serotonergic receptors in dmPAG and vlPAG columns, plays a critical role in the elaboration of post-ictal antinociception.

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Section: Synapsementioning

confidence: 98%

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT_2Aand 5-HT_2Cserotonergic receptors in post-ictal antinociception

Freitas

Oliveira

et al. 2013

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Biochemical and Pharmacologic Studies of Neurotransmitters in the Kindling Model

McNamara¹,

Bonhaus²,

Crain³

et al. 1987

Neurotransmitters and Epilepsy

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Opiate and non-opiate aspects of morphine induced seizures

et al. 1982

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Kindling-induced changes in morphine analgesia and catalepsy: Evidence for independent opioid systems

Cited by 12 publications

References 14 publications

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT_2Aand 5-HT_2Cserotonergic receptors in post-ictal antinociception

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT_2Aand 5-HT_2Cserotonergic receptors in post-ictal antinociception

Biochemical and Pharmacologic Studies of Neurotransmitters in the Kindling Model

Opiate and non-opiate aspects of morphine induced seizures

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Kindling-induced changes in morphine analgesia and catalepsy: Evidence for independent opioid systems

Cited by 12 publications

References 14 publications

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT2Aand 5-HT2Cserotonergic receptors in post-ictal antinociception

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT2Aand 5-HT2Cserotonergic receptors in post-ictal antinociception

Biochemical and Pharmacologic Studies of Neurotransmitters in the Kindling Model

Opiate and non-opiate aspects of morphine induced seizures

Contact Info

Product

Resources

About

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT_2Aand 5-HT_2Cserotonergic receptors in post-ictal antinociception

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT_2Aand 5-HT_2Cserotonergic receptors in post-ictal antinociception