“…Kindlin-1 is also found outside of integrin adhesions; for example, it has been shown to translocate in an integrin-and phosphorylation-dependent manner to centrosomes, where it participates in the assembly of the mitotic spindle (see Box 2) (Patel et al, 2013). In osteoclasts, kindlin-3 is predominantly found in podosomes, which seal a membrane pocket that contains proteases and proteins that are essential for bone resorption (Schmidt et al, 2011). Kindlin-2, probably with the help of its nuclear localization signal (NLS) (Ussar et al, 2006), can localize to the nucleus of smooth muscle cells (Kato et al, 2004) and breast cancer cells (Yu et al, 2012).…”