Kindlin‐1 drives early steps of breast cancer metastasis

Bonin, Florian; Chiche, Aurélie; Tariq, Zakia; Azorin, Paula; Nola, Sébastien; Lidereau, Rosette; Driouch, Keltouma

doi:10.1002/cac2.12338

Cited by 2 publications

(2 citation statements)

References 9 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Then, the tumor tissues were fixed using 4% paraformaldehyde for immunohistochemical analysis. Pathological changes were assessed through hematoxylin and eosin (H&E) staining, whereas tumor cell apoptosis was evaluated through caspase-3 antibody and terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling (TUNEL) staining (Figure c) . Compared with the control group, no significant cell necrosis and apoptosis was observed after 1d injection, whereas laser irradiation induced slight damage to tumor cells.…”

Section: Results and Discussionmentioning

confidence: 99%

Soluble Nanographene C₂₂₂: Synthesis and Applications for Synergistic Photodynamic/Photothermal Therapy

Ma,

Gao,

Chen

et al. 2024

J. Am. Chem. Soc.

View full text Add to dashboard Cite

Nanographene C222, which consists of a planar graphenic plane containing 222 carbon atoms, holds the record as the largest planar nanographene synthesized to date. However, its complete insolubility makes the processing of C222 difficult. Here we addressed this issue by introducing peripheral substituents perpendicular to the graphene plane, effectively disrupting the interlayer stacking and endowing C222 with good solubility. We also found that the electron-withdrawing substituents played a crucial role in the cyclodehydrogenation process, converting the dendritic polyphenylene precursor to C222. After disrupting the interlayer stacking, the introduction of only a few peripheral carboxylic groups allowed C222 to dissolve in phosphate buffer saline, reaching a concentration of up to 0.5 mg/mL. Taking advantage of the good photosensitizing and photothermal properties of the inner C222 core, the resulting water-soluble C222 emerged as a single-component agent for both photothermal and photodynamic tumor therapy, exhibiting an impressive tumor inhibition rate of 96%.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

Soluble Nanographene C₂₂₂: Synthesis and Applications for Synergistic Photodynamic/Photothermal Therapy

Ma,

Gao,

Chen

et al. 2024

J. Am. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…For example, hypoxia-inducibe factor (HIF) increases the expression of integrin α5β1 to accelerate metastasis of breast cancer towards lymph nodes and lung [ 64 ]. There is also research showing that integrin α5β1-mediated by kindlin-1 is involved in the early steps of breast cancer metastasis [ 65 ]. The crosstalk between integrin α4β1 and VCAM-1 induce melanoma and lymphoma metastasis to lung or spleen [ 66 ].…”

Section: Introductionmentioning

confidence: 99%

Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities

Li,

Sampson,

Liu

et al. 2023

Cell Commun Signal

View full text Add to dashboard Cite

Integrins are transmembrane receptors that possess distinct ligand-binding specificities in the extracellular domain and signaling properties in the cytoplasmic domain. While most integrins have a short cytoplasmic tail, integrin β4 has a long cytoplasmic tail that can indirectly interact with the actin cytoskeleton. Additionally, 'inside-out' signals can induce integrins to adopt a high-affinity extended conformation for their appropriate ligands. These properties enable integrins to transmit bidirectional cellular signals, making it a critical regulator of various biological processes.Integrin expression and function are tightly linked to various aspects of tumor progression, including initiation, angiogenesis, cell motility, invasion, and metastasis. Certain integrins have been shown to drive tumorigenesis or amplify oncogenic signals by interacting with corresponding receptors, while others have marginal or even suppressive effects. Additionally, different α/β subtypes of integrins can exhibit opposite effects. Integrin-mediated signaling pathways including Ras- and Rho-GTPase, TGFβ, Hippo, Wnt, Notch, and sonic hedgehog (Shh) are involved in various stages of tumorigenesis. Therefore, understanding the complex regulatory mechanisms and molecular specificities of integrins are crucial to delaying cancer progression and suppressing tumorigenesis. Furthermore, the development of integrin-based therapeutics for cancer are of great importance.This review provides an overview of integrin-dependent bidirectional signaling mechanisms in cancer that can either support or oppose tumorigenesis by interacting with various signaling pathways. Finally, we focus on the future opportunities for emergent therapeutics based on integrin agonists.

show abstract

Kindlin‐1 drives early steps of breast cancer metastasis

Cited by 2 publications

References 9 publications

Soluble Nanographene C₂₂₂: Synthesis and Applications for Synergistic Photodynamic/Photothermal Therapy

Soluble Nanographene C₂₂₂: Synthesis and Applications for Synergistic Photodynamic/Photothermal Therapy

Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities

Contact Info

Product

Resources

About

Kindlin‐1 drives early steps of breast cancer metastasis

Cited by 2 publications

References 9 publications

Soluble Nanographene C222: Synthesis and Applications for Synergistic Photodynamic/Photothermal Therapy

Soluble Nanographene C222: Synthesis and Applications for Synergistic Photodynamic/Photothermal Therapy

Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities

Contact Info

Product

Resources

About

Soluble Nanographene C₂₂₂: Synthesis and Applications for Synergistic Photodynamic/Photothermal Therapy

Soluble Nanographene C₂₂₂: Synthesis and Applications for Synergistic Photodynamic/Photothermal Therapy